Cell Death and Disease, 2021 Neutrophils are significant compositions of solid tumors and exert distinct functions in different types of tumors. However, the precise role of neutrophils in the progression of breast cancer (BC) is presently unclear.
Baochi Ou +5 more
doaj +2 more sources
C5aR1 and cGAS/STING and their possible involvement in radiosensitivity of colorectal cancer [PDF]
iScienceSummary: Worldwide, colorectal cancer (CRC) stands as the third leading cancer in terms of both diagnosis and mortality, underscoring its significant global health impact.
Quoc Thao Trang Pham +2 more
doaj +2 more sources
The insider's perspective: The intracellular complosome and immune cell dynamics in cancer. [PDF]
Clin Transl MedIntracellular complement (complosome) shapes the tumour immune microenvironment. Complosome's role in cancer is underrecognised yet central to tumour immunity. C3/C5‐driven complosome signals rewire T‐cell activation, fate and metabolism. Complosome activity can promote pro‐tumour immune cell function.
Bennion A, Lysaght J, Lynam-Lennon N.
europepmc +2 more sources
Innate Immune Cell Infiltration Induced by Polatuzumab Vedotin Contributes to the Antitumor Effect in Mouse Models. [PDF]
EJHaemABSTRACT Introduction Polatuzumab vedotin (Pola) is an antibody‐drug conjugate approved for the treatment of diffuse large B‐cell lymphoma (DLBCL). Several reports suggest that the tumor microenvironment influences the outcome of DLBCL treatments; with Pola, however, the link between tumor microenvironment and treatment outcome remains unclear ...
Tomita M +9 more
europepmc +2 more sources
UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment [PDF]
Cell Death and DiseaseDysregulation of the C5a-C5a receptor 1 (C5aR1) signalling axis underlies inflammation and immune-driven pathology. C5aR1 was traditionally thought to be primarily expressed on the cell membrane, although recent reports indicate the importance of ...
Tatsuya Suwa +10 more
doaj +2 more sources
Virulence, 2019 The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Marcel Muenstermann +6 more
doaj +2 more sources
Molecular Neurodegeneration, 2017 Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's disease (AD) mouse models.
Michael X. Hernandez +11 more
doaj +3 more sources
13-methylpalmatine alleviates myocardial ischemia/reperfusion injury by potentially targeting the C5a-C5aR1 axis to inhibit neutrophil extracellular trap formation [PDF]
Redox BiologyThe complement system activation-induced inflammation is a critical contributor to myocardial ischemia/reperfusion (I/R) injury. However, effective therapeutic targets and pharmacological interventions remain limited.
Miao Zhang +14 more
doaj +2 more sources
Evaluating the usefulness of C5 and C5AR1 as genetic biomarkers of IgA-mediated vasculitis [PDF]
Molecular MedicineBackground IgA-mediated vasculitis (IgAV) is a complex inflammatory disease. Unravelling its genetic background would allow us to identify genetic biomarkers that may be used as additional tools in its daily management, helping to solve the clinical ...
Joao Carlos Batista-Liz +23 more
doaj +2 more sources
C5a/C5aR1 mediates the IMQ-induced psoriatic skin inflammation via promoting IL-17A expression by γδ T cells in mice [PDF]
Jichu yixue yu linchuang, 2022 Objective To explore the effects and underlying mechanism of C5a/C5aR1 pathway in mediating imiquimod (IMQ)-induced psoriatic skin inflammation by increasing IL-17A expression in γδ T cells.
ZHENG Quan-you, LIANG Shen-ju,SHU Yong, ZHOU Shan, ZHONG Yu, SHENG Fen, TANG Ming-jun
doaj +1 more source