Novel interactions between the C5‐C5aR1 Axis and IF1: Implications for kidney mitochondrial physiology and ischemia–reperfusion injury [PDF]
Physiological ReportsIschemia‐reperfusion injury (IRI) is a prevalent condition that predominantly afflicts hospitalized patients, inducing acute kidney injury (AKI). In recent years, complement 5 (C5) and its anaphylatoxin receptor C5aR1 have been implicated in driving ...
Madison McGraw +5 more
doaj +2 more sources
Complement C5a receptor 1 antagonist attenuates alveolar hypoplasia induced by pulmonary hypoperfusion and its underlying mechanisms [PDF]
Frontiers in ImmunologyBackgroundTo elucidate the role of complement component C5a in pulmonary hypoperfusion (PHypo)-induced alveolar hypoplasia, given its centrality in sterile inflammation and the recent implication of immune activation in a neonatal rat PHypo model ...
Chenxi Liu +14 more
doaj +2 more sources
C5aR1 and cGAS/STING and their possible involvement in radiosensitivity of colorectal cancer [PDF]
iScienceSummary: Worldwide, colorectal cancer (CRC) stands as the third leading cancer in terms of both diagnosis and mortality, underscoring its significant global health impact.
Quoc Thao Trang Pham +2 more
doaj +2 more sources
Pathogens, 2015 The complement anaphylatoxin C5a contributes to host defense against Staphylococcus aureus. In this study, we investigated the functional role of the two known C5a receptors, C5aR1 and C5aR2, in the host response to S. aureus. We found that C5aR1−/− mice
Andreas Klos +2 more
exaly +3 more sources
UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment [PDF]
Cell Death and DiseaseDysregulation of the C5a-C5a receptor 1 (C5aR1) signalling axis underlies inflammation and immune-driven pathology. C5aR1 was traditionally thought to be primarily expressed on the cell membrane, although recent reports indicate the importance of ...
Tatsuya Suwa +10 more
doaj +2 more sources
Virulence, 2019 The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Andreas Klos +2 more
exaly +2 more sources
13-methylpalmatine alleviates myocardial ischemia/reperfusion injury by potentially targeting the C5a-C5aR1 axis to inhibit neutrophil extracellular trap formation [PDF]
Redox BiologyThe complement system activation-induced inflammation is a critical contributor to myocardial ischemia/reperfusion (I/R) injury. However, effective therapeutic targets and pharmacological interventions remain limited.
Miao Zhang +14 more
doaj +2 more sources
C5a/C5aR1 mediates the IMQ-induced psoriatic skin inflammation via promoting IL-17A expression by γδ T cells in mice [PDF]
Jichu yixue yu linchuang, 2022 Objective To explore the effects and underlying mechanism of C5a/C5aR1 pathway in mediating imiquimod (IMQ)-induced psoriatic skin inflammation by increasing IL-17A expression in γδ T cells.
ZHENG Quan-you, LIANG Shen-ju,SHU Yong, ZHOU Shan, ZHONG Yu, SHENG Fen, TANG Ming-jun
doaj +1 more source
Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody
Journal of Innate Immunity, 2023 Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka +6 more
doaj +1 more source
The C5a/C5aR1 axis controls the development of experimental allergic asthma independent of LysM-expressing pulmonary immune cells. [PDF]
PLoS ONE, 2017 C5a regulates the development of maladaptive immune responses in allergic asthma mainly through the activation of C5a receptor 1 (C5aR1). Yet, the cell types and the mechanisms underlying this regulation are ill-defined.
Anna V Wiese +7 more
doaj +1 more source