Results 21 to 30 of about 4,383 (167)

Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b⁺ cDCs Promotes Pulmonary Tolerance through Downregulation of CD40

Cells, 2020
Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore the underlying regulatory mechanisms, we analyzed the impact of C5aR1 activation on pulmonary CD11b+ conventional ...
Konstantina Antoniou, Fanny Ender, Tillman Vollbrandt, Yves Laumonnier, Franziska Rathmann, Chandrashekhar Pasare, Harinder Singh, Jörg Köhl   +7 more
doaj   +1 more source

Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase. [PDF]

PLoS ONE, 2017
C5a drives airway constriction and inflammation during the effector phase of allergic asthma, mainly through the activation of C5a receptor 1 (C5aR1). Yet, C5aR1 expression on myeloid and lymphoid cells during the allergic effector phase is ill-defined ...
Fanny Ender, Anna V Wiese, Inken Schmudde, Jing Sun, Tillman Vollbrandt, Peter König, Yves Laumonnier, Jörg Köhl   +7 more
doaj   +1 more source

C5aR1-positive neutrophils promote breast cancer glycolysis through WTAP-dependent m6A methylation of ENO1

Cell Death and Disease, 2021
Neutrophils are significant compositions of solid tumors and exert distinct functions in different types of tumors. However, the precise role of neutrophils in the progression of breast cancer (BC) is presently unclear.
Baochi Ou, Yuan Liu, Xiaowei Yang, Xiaojun Xu, Yunwen Yan, Jingjie Zhang   +5 more
doaj   +1 more source

Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models

Journal of Neuroinflammation, 2023
The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer’s disease progression has been highlighted over the past few years.
Tiffany J. Petrisko, Matthew Gargus, Shu-Hui Chu, Purnika Selvan, Katrine L. Whiteson, Andrea J. Tenner   +5 more
doaj   +1 more source

Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages

Journal of Innate Immunity, 2023
Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of infection or injury and secretion of inflammatory chemokines are promoted by complement component 5a (C5a ...
Kai-Chen Wu, Nicholas D Condon, Timothy A. Hill, Robert C. Reid, David Fairlie, Junxian Lim   +5 more
doaj   +1 more source

C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps

The Journal of Clinical Investigation, 2023
Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that may progress to cytokine storm syndrome, organ dysfunction, and death.
Bruna M. Silva, Giovanni F. Gomes, Flavio P. Veras, Seppe Cambier, Gabriel V.L. Silva, Andreza U. Quadros, Diego B. Caetité, Daniele C. Nascimento, Camilla M. Silva, Juliana C. Silva, Samara Damasceno, Ayda H. Schneider, Fabio Beretta, Sabrina S. Batah, Icaro M.S. Castro, Isadora M. Paiva, Tamara Rodrigues, Ana Salina, Ronaldo Martins, Guilherme C.M. Cebinelli, Naira L. Bibo, Daniel M. Jorge, Helder I. Nakaya, Dario S. Zamboni, Luiz O. Leiria, Alexandre T. Fabro, José C. Alves-Filho, Eurico Arruda, Paulo Louzada-Junior, Renê D. Oliveira, Larissa D. Cunha, Pierre Van Mol, Lore Vanderbeke, Simon Feys, Els Wauters, Laura Brandolini, Andrea Aramini, Fernando Q. Cunha, Jörg Köhl, Marcello Allegretti, Diether Lambrechts, Joost Wauters, Paul Proost, Thiago M. Cunha   +43 more
doaj   +1 more source

Targeting C5aR1 Increases the Therapeutic Window of Radiotherapy [PDF]

, 2020
Abstract Engaging innate immune pathways is emerging as a productive way of achieving durable anti-tumor responses. However, systemic administration of these therapies can result in toxicity, deemed to be particularly problematic when combined with current standard-of-care cytotoxic treatments such as radiotherapy.
Monica M. Olcina, Melemenidis Stavros, Dhanya K. Nambiar, Ryan K. Kim, Kerriann M. Casey, von Eyben Rie, Trent M. Woodruff, Edward G. Graves, Le Quynh-Thu, Stucki Manuel, Amato J. Giaccia   +10 more
openaire   +1 more source

Immunohistochemical identification of complement peptide C5a receptor 1 (C5aR1) in non-neoplastic and neoplastic human tissues.

PLoS ONE, 2021
The complement component C5a and its receptor C5aR1 are involved in the development of numerous inflammatory diseases. In addition to immune cells, C5aR1 is expressed in neoplastic cells of multiple tumour entities, where C5aR1 is associated with a ...
Benjamin Nürge, Alan Lennart Schulz, Daniel Kaemmerer, Jörg Sänger, Katja Evert, Stefan Schulz, Amelie Lupp   +6 more
doaj   +1 more source

C5aR1 blockade reshapes immunosuppressive tumor microenvironment and synergizes with immune checkpoint blockade therapy in high-grade serous ovarian cancer

OncoImmunology, 2023
High-grade serous ovarian cancer (HGSC), with a modest response to immune checkpoint blockade (ICB) targeting PD-1/PD-L1 monotherapy, is densely infiltrated by M2-polarized tumor-associated macrophages (TAMs) and regulatory T (Treg) cells. The complement
Chen Zhang, Kankan Cao, Moran Yang, Yiying Wang, Mengdi He, Jiaqi Lu, Yan Huang, Guodong Zhang, Haiou Liu   +8 more
doaj   +1 more source

Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy

Cytokine, 2023
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of several antitumor agents resulting in progressive and often irreversible damage of peripheral nerves. In addition to their known anticancer effects, taxanes, including paclitaxel, can also induce peripheral neuropathy by activating microglia and astrocytes, which release pro ...
Cristiano, C, Giorgio, C, Cocchiaro, P, Boccella, S, Cesta, M C, Castelli, V, Liguori, F M, Cuozzo, M R, Brandolini, L, Russo, R, Allegretti, M   +10 more
openaire   +4 more sources