Results 21 to 30 of about 5,552 (193)

Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection

Pathogens, 2015
The complement anaphylatoxin C5a contributes to host defense against Staphylococcus aureus. In this study, we investigated the functional role of the two known C5a receptors, C5aR1 and C5aR2, in the host response to S. aureus. We found that C5aR1−/− mice
Andreas Klos, Andreas Beineke, Eva Medina   +2 more
exaly   +3 more sources

Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4

Cell Death and Disease
Glioblastoma (GBM) is the most common primary intracranial malignant tumor. Recent literature suggests that induction of programmed death has become a mainstream cancer treatment strategy, with ferroptosis being the most widely studied mode.
Xiangrui Meng, Zixuan Wang, Qingqing Yang, Yawei Liu, Yisu Gao, Hefei Chen, Ang Li, Rongqing Li, Jun Wang, Guan Sun   +9 more
doaj   +2 more sources

C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis [PDF]

Frontiers in Immunology, 2019
Psoriasis is one of the most common chronic inflammatory skin diseases, affecting ~2% of the population. The lack of characterization of the pathogenesis of psoriasis has hindered efficient clinical treatment of the disease.
Quan-you Zheng, Quan-you Zheng, Shen-ju Liang, Feng Xu, Gui-qing Li, Na Luo, Shun Wu, You Li, Ming Tang, Yu Zhong, Jian Chen, Di Yang, Dao-dong Sun, Ke-qin Zhang, Gui-lian Xu   +14 more
doaj   +3 more sources

Complement C5a receptor 1 antagonist attenuates alveolar hypoplasia induced by pulmonary hypoperfusion and its underlying mechanisms [PDF]

Frontiers in Immunology
BackgroundTo elucidate the role of complement component C5a in pulmonary hypoperfusion (PHypo)-induced alveolar hypoplasia, given its centrality in sterile inflammation and the recent implication of immune activation in a neonatal rat PHypo model ...
Chenxi Liu, Sixie Zheng, Ye Wang, Ziwen Wang, Debao Li, Hao Li, Yiting Xue, Zheng Wang, Siqi She, Lincai Ye, Lincai Ye, Lincai Ye, Peisen Ruan, Lijun Fu, Qi Sun   +14 more
doaj   +2 more sources

Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections

Virulence, 2019
The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Andreas Klos, Kay O Johswich, Jörg Köhl   +2 more
exaly   +2 more sources

C5a–C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms

Scientific Reports
Recent studies have indicated the involvement of neutrophil-mediated inflammatory responses in the process leading to intracranial aneurysm (IA) rupture. Receptors mediating neutrophil recruitment could thus be therapeutic targets of unruptured IAs.
Akihiro Okada, Kampei Shimizu, Akitsugu Kawashima, Tomomichi Kayahara, Masahiko Itani, Hiroki Kurita, Susumu Miyamoto, Hiroharu Kataoka, Tomohiro Aoki   +8 more
doaj   +3 more sources

C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages

Journal of Immunology Research
As another receptor for complement activation product C5a, C5aR2 has been paid much attention these years. Although controversial and complex, its specific signals or roles in modulating the classic receptor C5aR1 have been investigated and gradually ...
Ting Zhang, Ning Ma, Jiaxing Wang, Xiaoyun Min, Linlin Wei, Ke Li   +5 more
doaj   +3 more sources

Targeting C5AR1 disrupts complement-driven G0-phase maintenance and overcomes metabolic drug resistance in glioma [PDF]

Journal of Translational Medicine
Background Glioblastoma (GBM) relapse and drug resistance are driven by a subset of quiescent, therapy-tolerant cells that persist in the G0 phase.
Yu Qian, Kai Zhao
doaj   +2 more sources

13-methylpalmatine alleviates myocardial ischemia/reperfusion injury by potentially targeting the C5a-C5aR1 axis to inhibit neutrophil extracellular trap formation

Redox Biology
The complement system activation-induced inflammation is a critical contributor to myocardial ischemia/reperfusion (I/R) injury. However, effective therapeutic targets and pharmacological interventions remain limited.
Miao Zhang, Shan Gao, Nannan Tan, Yu Yan, Rongxin Zhu, Jiajing Liu, Qin Mao, Keyan Wang, Wenhao Zhang, Gang Wang, Zhuo Wang, Tieshan Wang, Xueshi Huang, Rong Zhang, Baofeng Yang   +14 more
doaj   +2 more sources

Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner

Cell Death and Disease
Targeting C5aR1 modulates the function of infiltrated immune cells including tumor-associated macrophages (TAMs). The gut microbiome plays a pivotal role in colorectal cancer (CRC) tumorigenesis and development through TAM education. However, whether and
Jie Zhao, Chen Yao, Yongqin Qin, Hanyong Zhu, Hui Guo, Binbin Ji, Xueqin Li, Na Sun, Rongqing Li, Yuzhang Wu, Kuiyang Zheng, Yuchen Pan, Tingting Zhao, Jing Yang   +13 more
doaj   +2 more sources