Results 21 to 30 of about 6,618 (201)
The C5a/C5aR1 axis controls the development of experimental allergic asthma independent of LysM-expressing pulmonary immune cells. [PDF]
PLoS ONE, 2017 C5a regulates the development of maladaptive immune responses in allergic asthma mainly through the activation of C5a receptor 1 (C5aR1). Yet, the cell types and the mechanisms underlying this regulation are ill-defined.
Anna V Wiese +7 more
doaj +1 more source
Specific inhibition of complement activation significantly ameliorates autoimmune blistering disease in mice [PDF]
, 2018 Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7).
B. Paul Morgan +11 more
core +15 more sources
Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse [PDF]
The Journal of Immunology, 2015 Abstract Many of the biological properties of C5a are mediated through activation of its receptor (C5aR1), the expression of which has been demonstrated convincingly on myeloid cells, such as neutrophils, monocytes, and macrophages. In contrast, conflicting results exist regarding C5aR1 expression in dendritic cells (DCs) and lymphoid ...
Christian M, Karsten +9 more
openaire +2 more sources
C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli [PDF]
JCI Insight, 2017 C5a receptor 1 (C5aR1) is a G protein-coupled receptor for C5a and also an N-linked glycosylated protein. In addition to myeloid cells, C5aR1 is expressed on epithelial cells. In this study, we examined the role of C5aR1 in bacterial adhesion/colonization of renal tubular epithelium and addressed the underlying mechanisms of this role.
Li K +15 more
openaire +3 more sources
The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics [PDF]
Trends in Immunology, 2020 The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy ...
Woodruff, Trent M., Shukla, Arun K.
openaire +6 more sources
Cells, 2020 Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore the underlying regulatory mechanisms, we analyzed the impact of C5aR1 activation on pulmonary CD11b+ conventional ...
Konstantina Antoniou +7 more
doaj +1 more source
Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase. [PDF]
PLoS ONE, 2017 C5a drives airway constriction and inflammation during the effector phase of allergic asthma, mainly through the activation of C5a receptor 1 (C5aR1). Yet, C5aR1 expression on myeloid and lymphoid cells during the allergic effector phase is ill-defined ...
Fanny Ender +7 more
doaj +1 more source
Journal of Innate Immunity, 2023 Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of infection or injury and secretion of inflammatory chemokines are promoted by complement component 5a (C5a ...
Kai-Chen Wu +5 more
doaj +1 more source
Cancer Research, 2021 Abstract C5AR1 (complement C5a receptor 1) is a classical G protein-coupled receptor that is mainly expressed on granulocytes, monocytes, dendritic cells and MDSCs (Myeloid-derived suppressor cells) in several cancer types. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature cells that play a significant role ...
Yanhui Nie +4 more
openaire +1 more source
Journal of Neuroinflammation, 2023 The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer’s disease progression has been highlighted over the past few years.
Tiffany J. Petrisko +5 more
doaj +1 more source