Results 21 to 30 of about 4,346 (168)
Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse [PDF]
The Journal of Immunology, 2015 Abstract Many of the biological properties of C5a are mediated through activation of its receptor (C5aR1), the expression of which has been demonstrated convincingly on myeloid cells, such as neutrophils, monocytes, and macrophages. In contrast, conflicting results exist regarding C5aR1 expression in dendritic cells (DCs) and lymphoid ...
Christian M, Karsten +9 more
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Mechanism of activation and biased signaling in complement receptor C5aR1
Cell Research, 2023 AbstractThe complement system plays an important role in the innate immune response to invading pathogens. The complement fragment C5a is one of its important effector components and exerts diverse physiological functions through activation of the C5a receptor 1 (C5aR1) and associated downstream G protein and β-arrestin signaling pathways.
Yuying Feng +12 more
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Cells, 2020 Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore the underlying regulatory mechanisms, we analyzed the impact of C5aR1 activation on pulmonary CD11b+ conventional ...
Konstantina Antoniou +7 more
doaj +1 more source
Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase. [PDF]
PLoS ONE, 2017 C5a drives airway constriction and inflammation during the effector phase of allergic asthma, mainly through the activation of C5a receptor 1 (C5aR1). Yet, C5aR1 expression on myeloid and lymphoid cells during the allergic effector phase is ill-defined ...
Fanny Ender +7 more
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Cell Death and Disease, 2021 Neutrophils are significant compositions of solid tumors and exert distinct functions in different types of tumors. However, the precise role of neutrophils in the progression of breast cancer (BC) is presently unclear.
Baochi Ou +5 more
doaj +1 more source
Journal of Innate Immunity, 2023 Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of infection or injury and secretion of inflammatory chemokines are promoted by complement component 5a (C5a ...
Kai-Chen Wu +5 more
doaj +1 more source
Journal of Neuroinflammation, 2023 The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer’s disease progression has been highlighted over the past few years.
Tiffany J. Petrisko +5 more
doaj +1 more source
Targeting C5aR1 Increases the Therapeutic Window of Radiotherapy [PDF]
, 2020 Abstract Engaging innate immune pathways is emerging as a productive way of achieving durable anti-tumor responses. However, systemic administration of these therapies can result in toxicity, deemed to be particularly problematic when combined with current standard-of-care cytotoxic treatments such as radiotherapy.
Monica M. Olcina +10 more
openaire +1 more source
C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps
The Journal of Clinical Investigation, 2023 Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that may progress to cytokine storm syndrome, organ dysfunction, and death.
Bruna M. Silva +43 more
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OncoImmunology, 2023 High-grade serous ovarian cancer (HGSC), with a modest response to immune checkpoint blockade (ICB) targeting PD-1/PD-L1 monotherapy, is densely infiltrated by M2-polarized tumor-associated macrophages (TAMs) and regulatory T (Treg) cells. The complement
Chen Zhang +8 more
doaj +1 more source