Helix 8 in chemotactic receptors of the complement system.
PLoS Computational Biology, 2022 Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski +3 more
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Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner [PDF]
, 2011 By gating cell cycle progression to specific times of the day, the intracellular circadian clock is thought to reduce the exposure of replicating cells to potentially hazardous environmental and endogenous genotoxic compounds.
Destici Eugin +4 more
core +1 more source
Future Needs in Mast Cell Biology. [PDF]
, 2019 The pathophysiological roles of mast cells are still not fully understood, over 140 years since their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct "subpopulations" of mast cells based on a relatively small ...
de Paulis, Amato +3 more
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Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]
, 2020 Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo +16 more
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Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo [PDF]
, 2013 Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue damage is a hallmark of early innate immune responses, and the molecular events leading to cell exit from the bloodstream have been well defined1,2. Once outside the
Afonso, P. +6 more
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FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins
Life Science Alliance, 2023 FBXO11 regulates the expression of the complement receptor C5aR1 and the inflammatory cytokine IL-1β, affecting how macrophages respond to Staphylococcus aureus pore–forming toxins.
Yusun Jeon +9 more
doaj +1 more source
Inflammasome priming in sterile inflammatory disease [PDF]
, 2017 The inflammasome is a cytoplasmic protein complex that processes interleukins (IL)-1β and IL-18, and drives a form of cell death known as pyroptosis. Oligomerization of this complex is actually the second step of activation, and a priming step must occur
Bryant, Clare E. +9 more
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Molecular Changes in Pre-Metastatic Lymph Nodes of Esophageal Cancer Patients [PDF]
, 2014 Lymph node metastasis indicates poor prognosis in esophageal cancer. To understand the underlying mechanisms, most studies so far focused on investigating the tumors themselves and/or invaded lymph nodes.
Izbicki, J.R. +9 more
core +7 more sources
TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection
Frontiers in Immunology, 2023 BackgroundAn essential fact underlying the severity of Staphylococcus aureus (S. aureus) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane receptors.
Jie He +6 more
doaj +1 more source
Global impact of Salmonella type III secretion effector SteA on host cells [PDF]
, 2014 Salmonella enterica is a Gram-negative bacterium that causes gastroenteritis, bacteremia and typhoid fever in several animal species including humans. Its virulence is greatly dependent on two type III secretion systems, encoded in pathogenicity islands ...
Cardenal Muñoz, Elena +2 more
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