Results 51 to 60 of about 6,618 (201)

C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation

Theranostics, 2020
Numerous factors have been claimed to play important roles in colorectal cancer (CRC) tumorigenesis, including myeloid-derived suppressor cells (MDSCs) and other immune cells, cytokines, and chemokines; however, the precise mechanisms of colorectal tumorigenesis remain elusive, and there is a lack of effective preventive treatments.
Ding, Peipei, Li, Ling, Li, Luying, Lv, Xinyue, Zhou, Danlei, Wang, Qingkai, Chen, Jianfeng, Yang, Chaoqun, Xu, Enjie, Dai, Weixing, Zhang, Xin, Wang, Na, Wang, Qi, Zhang, Wei, Zhang, Long, Zhou, Yuzhen, Gu, Hongyu, Lei, Qunying, Zhou, Xuhui, Hu, Weiguo   +19 more
openaire   +2 more sources

Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia [PDF]

, 2017
TCRγδ+ T-LGL leukemia is a rare form of chronic mature T cell disorders in elderly, which is generally characterized by a ...
De Ridder, D. (Dick), Dongen, J.J.M. (Jacques) van, Kallemeijn, M.J. (Martine), Langerak, A.W. (Anton), Sandberg, Y. (Yorick), Schilperoord-Vermeulen, J. (Joyce), Van Der Klift, M.Y. (Michèle Y.)   +6 more
core   +1 more source

Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Sbcutaneous Adipose Tissue and Adipocytes in Acquired Obesity [PDF]

, 2017
Inflammation is an important mediator of obesity-related complications such as the metabolic syndrome but its causes and mechanisms are unknown. As the complement system is a key mediator of inflammation, we studied whether it is activated in acquired ...
Hakkarainen, Antti, Hanttu, Anna, Heinonen, Sini, Kaprio, Jaakko, Kaye, Sanna, Lokki, A. Inkeri, Lundbom, Jesper, Lundbom, Nina, Meri, Seppo, Muniandy, Maheswary, Nissilä, Eija, Pietiläinen, Kirsi H., Rissanen, Aila, Saarinen, Lilli, Tynninen, Olli   +14 more
core   +1 more source

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Skeletal Muscle, 2017
Background The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune ...
Haitao A. Wang, John D. Lee, Kah Meng Lee, Trent M. Woodruff, Peter G. Noakes   +4 more
doaj   +1 more source

Isolation site influences virulence phenotype of serotype 14 Streptococcus pneumoniae strains belonging to multilocus sequence type 15 [PDF]

, 2015
Streptococcus pneumoniae is a diverse species causing invasive as well as localized infections that result in massive global morbidity and mortality. Strains vary markedly in pathogenic potential, but the molecular basis is obscured by the diversity and ...
Amin, Zarina, Harvey, Richard M., Hughes, Catherine E., Paton, Adrienne W., Paton, James C., Trappetti, Claudia, Wang, Hui   +6 more
core   +1 more source

Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection

Pathogens, 2015
The complement anaphylatoxin C5a contributes to host defense against Staphylococcus aureus. In this study, we investigated the functional role of the two known C5a receptors, C5aR1 and C5aR2, in the host response to S. aureus. We found that C5aR1−/− mice
Sarah A. Horst, Andreas Itzek, Andreas Klos, Andreas Beineke, Eva Medina   +4 more
doaj   +1 more source

Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure

Biological Psychiatry Global Open Science
Background: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive.
Hsiao-Jou Cortina Chen, Jereme G. Spiers, Titaya Lerskiatiphanich, Sandra E. Parker, Nickolas A. Lavidis, Jenny N. Fung, Trent M. Woodruff, John D. Lee   +7 more
doaj   +1 more source

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

Neurobiology of Disease, 2015
The role of complement system-mediated inflammation is of key interest in seizure and epilepsy pathophysiology, but its therapeutic potential has not yet been explored.
Melissa J. Benson, Nicola K. Thomas, Sahil Talwar, Mark P. Hodson, Joseph W. Lynch, Trent M. Woodruff, Karin Borges   +6 more
doaj   +1 more source

Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions

Cell Death and Disease, 2022
Chemotherapy-induced peripheral neuropathy (CIPN) and hypersensitivity reactions (HSRs) are among the most frequent and impairing side effects of the antineoplastic agent paclitaxel.
Laura Brandolini, Michele d’Angelo, Rubina Novelli, Vanessa Castelli, Cristina Giorgio, Anna Sirico, Pasquale Cocchiaro, Francesco D’Egidio, Elisabetta Benedetti, Claudia Cristiano, Antonella Bugatti, Anna Ruocco, Pier Giorgio Amendola, Carmine Talarico, Candida Manelfi, Daniela Iaconis, Andrea Beccari, Andreza U. Quadros, Thiago M. Cunha, Arnaldo Caruso, Roberto Russo, Annamaria Cimini, Andrea Aramini, Marcello Allegretti   +23 more
doaj   +1 more source

Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients

Frontiers in Immunology, 2022
Bullous pemphigoid (BP), the by far most frequent autoimmune subepidermal blistering disorder (AIBD), is characterized by the deposition of autoantibodies against BP180 (type XVII collagen; Col17) and BP230 as well as complement components at the dermal ...
Shirin Emtenani, Maike M. Holtsche, Richard Stahlkopf, Daniel L. Seiler, Timothy Burn, Huiqing Liu, Melissa Parker, Kaan Yilmaz, Hasan O. Dikmen, Markus Huber Lang, Christian D. Sadik, Christian M. Karsten, Nina van Beek, Ralf J. Ludwig, Ralf J. Ludwig, Jörg Köhl, Jörg Köhl, Enno Schmidt, Enno Schmidt   +18 more
doaj   +1 more source