Results 51 to 60 of about 5,552 (193)

C5aR1 blockade reshapes immunosuppressive tumor microenvironment and synergizes with immune checkpoint blockade therapy in high-grade serous ovarian cancer

OncoImmunology, 2023
High-grade serous ovarian cancer (HGSC), with a modest response to immune checkpoint blockade (ICB) targeting PD-1/PD-L1 monotherapy, is densely infiltrated by M2-polarized tumor-associated macrophages (TAMs) and regulatory T (Treg) cells. The complement
Chen Zhang, Kankan Cao, Moran Yang, Yiying Wang, Mengdi He, Jiaqi Lu, Yan Huang, Guodong Zhang, Haiou Liu   +8 more
doaj   +1 more source

Helix 8 in chemotactic receptors of the complement system.

PLoS Computational Biology, 2022
Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski, Paulina Dragan, Anna Makal, Dorota Latek   +3 more
doaj   +1 more source

The Pleiotropic Effect of Complement C5a-C5aR1 Pathway in Diseases: From Immune Regulation to Targeted Therapy. [PDF]

Int J Mol Sci
The complement system plays a pivotal role in the body’s immune defense mechanism. Its key effector molecule C5a and its primary receptor C5aR1 exhibit complex “double-edged sword” effects in various disease processes, including infectious diseases ...
Xu B, Zhou Z, Xiao Y, Liu Q, Xiao T, Lv Z, Wang H.   +6 more
europepmc   +2 more sources

The role of C5a-C5aR1 axis in bone pathophysiology: A mini-review

Frontiers in Cell and Developmental Biology, 2022
Bone remodeling is a physiological, dynamic process that mainly depends on the functions of 2 cell types: osteoblasts and osteoclasts. Emerging evidence suggests that complement system is crucially involved in the regulation of functions of these cells, especially during inflammatory states.
Anna Ruocco, Anna Sirico, Rubina Novelli, Silvia Iannelli, Shane Vontelin Van Breda, Diego Kyburz, Paul Hasler, Andrea Aramini, Pier Giorgio Amendola   +8 more
openaire   +3 more sources

FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins

Life Science Alliance, 2023
FBXO11 regulates the expression of the complement receptor C5aR1 and the inflammatory cytokine IL-1β, affecting how macrophages respond to Staphylococcus aureus pore–forming toxins.
Yusun Jeon, Seong H Chow, Isabella Stuart, Ashley Weir, Amy TY Yeung, Christine Hale, Sushmita Sridhar, Gordon Dougan, James E Vince, Thomas Naderer   +9 more
doaj   +1 more source

Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy

Cytokine, 2023
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of several antitumor agents resulting in progressive and often irreversible damage of peripheral nerves. In addition to their known anticancer effects, taxanes, including paclitaxel, can also induce peripheral neuropathy by activating microglia and astrocytes, which release pro ...
Cristiano, C, Giorgio, C, Cocchiaro, P, Boccella, S, Cesta, M C, Castelli, V, Liguori, F M, Cuozzo, M R, Brandolini, L, Russo, R, Allegretti, M   +10 more
openaire   +4 more sources

Abstract 2950: Humanized C5AR1 mouse model (B-hC5AR1 mice) for evaluation of anti-C5AR1 mAb in vivo efficacy

Cancer Research, 2021
Abstract C5AR1 (complement C5a receptor 1) is a classical G protein-coupled receptor that is mainly expressed on granulocytes, monocytes, dendritic cells and MDSCs (Myeloid-derived suppressor cells) in several cancer types. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature cells that play a significant role ...
Yanhui Nie, Xiaofei Zhou, Jing Zhang, Veronika Chromikova, Yuelei Shen   +4 more
openaire   +1 more source

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Skeletal Muscle, 2017
Background The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune ...
Haitao A. Wang, John D. Lee, Kah Meng Lee, Trent M. Woodruff, Peter G. Noakes   +4 more
doaj   +1 more source

Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure

Biological Psychiatry Global Open Science
Background: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive.
Hsiao-Jou Cortina Chen, Jereme G. Spiers, Titaya Lerskiatiphanich, Sandra E. Parker, Nickolas A. Lavidis, Jenny N. Fung, Trent M. Woodruff, John D. Lee   +7 more
doaj   +1 more source

Finerenone Alleviates Over-Activation of Complement C5a-C5aR1 Axis of Macrophages by Regulating G Protein Subunit Alpha i2 to Improve Diabetic Nephropathy

Cells
Diabetic nephropathy (DN), one of the most common complications of diabetes mellitus (DM), accounts for a major cause of chronic kidney disease (CKD) worldwide, with a complicated pathogenesis and limited effective strategies nowadays.
Zi-Han Li, Zi-Jun Sun, S. Tang, Ming-Hui Zhao, Min Chen, D. Chang   +5 more
semanticscholar   +1 more source