Results 71 to 80 of about 5,552 (193)

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

ACSL4 Drives C5a/C5aR1–Calcium-Induced Fibroblast-to-Myofibroblast Transition in a Bleomycin-Induced Mouse Model of Pulmonary Fibrosis

Biomolecules
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive extracellular matrix (ECM) deposition driven by aberrant fibroblast-to-myofibroblast transition (FMT).
Tingting Ren, Jia Shi, Li-Li Zhuang, Rui-Ting Su, Yi-Mei Lai, Nian-Sheng Yang   +5 more
semanticscholar   +1 more source

C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation

Theranostics, 2020
Numerous factors have been claimed to play important roles in colorectal cancer (CRC) tumorigenesis, including myeloid-derived suppressor cells (MDSCs) and other immune cells, cytokines, and chemokines; however, the precise mechanisms of colorectal tumorigenesis remain elusive, and there is a lack of effective preventive treatments.
Ding, Peipei, Li, Ling, Li, Luying, Lv, Xinyue, Zhou, Danlei, Wang, Qingkai, Chen, Jianfeng, Yang, Chaoqun, Xu, Enjie, Dai, Weixing, Zhang, Xin, Wang, Na, Wang, Qi, Zhang, Wei, Zhang, Long, Zhou, Yuzhen, Gu, Hongyu, Lei, Qunying, Zhou, Xuhui, Hu, Weiguo   +19 more
openaire   +2 more sources

The effects of C5aR1 on leukocyte infiltration following pilocarpine‐induced status epilepticus [PDF]

Epilepsia, 2017
SummaryThis study aimed to determine the role C5aR1 plays in mediating immune responses acutely after pilocarpine‐induced status epilepticus (SE), specifically those of brain‐infiltrating leukocytes. Three days following pilocarpine SE, we determined by flow cytometry the brain immune cell phenotypes and measured key proinflammatory and ...
Benson, Melissa J., Manzanero, Silvia, Borges, Karin   +2 more
openaire   +5 more sources

Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR1) in lupus nephritis: A novel therapeutic target. [PDF]

J Cell Commun Signal
Lupus nephritis (LN), a renal manifestation of systemic lupus erythematosus, results from immune‐mediated kidney injury. The present study investigated how complement component 5a (C5a) and its receptor (C5aR1) regulate phosphatase and tensin homolog ...
Ma Y, Wang Y, Zhao P, Cheng L, Li L, Li R, Zhou X.   +6 more
europepmc   +2 more sources

Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy

Allergy, EarlyView.
Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider, Juan‐Felipe López, Huseyn Babayev, Willem van de Veen, Minglin Yang, Cezmi A. Akdis, Kari Nadeau, Carolyn H. Baloh, Stacie M. Jones, Lisa M. Wheatley, Mübeccel Akdis, IMPACT, Amy M. Scurlock, D. Pesek, Joy Laurienzo‐Panza, Marshall Plaut, A. Wesley Burks, Edwin H. Kim, Mike Kulis, Anna Nowak‐Wegrzyn, Hugh A. Sampson, Julie Wang, Robert A. Wood, Sharon Chinthrajah, Robert Sayantani B. Sindher, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Rachel Yan, Don Whitehouse, Michelle L. Sever, Srinath Sanda, David Larson, Tielin Qin, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien‐Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh‐Anh Nguyen, Jessica Garber, Kimberly O'Brien, Brandon Larson, C. Cousens‐Jacobs, Alex Hu   +48 more
wiley   +1 more source

Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis

Nature Communications
Over 60% of women with endometriosis experience abdominopelvic pain and broader pain manifestations, including chronic back pain, fibromyalgia, chronic fatigue, vulvodynia, and migraine.
Mustafa Titiz, L. Landini, Daniel Souza Monteiro de Araújo, Matilde Marini, V. Seravalli, M. Chieca, Pasquale Pensieri, Marco Montini, G. De Siena, B. Pasquini, S. Vannuccini, L. Iannone, T. M. Cunha, Giulia Brancolini, Elisa Bellantoni, Irene Scuffi, Alessandra Mastricci, Martina Tesi, M. Di Tommaso, F. Petraglia, P. Geppetti, R. Nassini, Francesco De Logu   +22 more
semanticscholar   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

C5aR1 inhibition reprograms tumor associated macrophages and reverses PARP inhibitor resistance in breast cancer

Nature Communications
Although Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have been approved in multiple diseases, including BRCA1/2 mutant breast cancer, responses are usually transient requiring the deployment of combination therapies for optimal efficacy.
Xi Li, A. Poire, Kang Jin Jeong, Dong Zhang, T. Ozmen, Gang Chen, Chao-Yang Sun, G. Mills   +7 more
semanticscholar   +1 more source

The role of C5aR1-mediated hepatic macrophage efferocytosis in NASH

Scientific Reports
Abstract NAFLD has become the first major chronic liver disease in developed countries. 10-20% of NAFLD patients will progress to NASH, and up to 25% of NASH patients may develop cirrhosis within 10 years. Therefore, it is critical to find key factors that may treat this disease.
Xuan Shen, Wenxing Zheng, Xinna Du, Yuping Chen, Xianping song, Liucai Yang, Qi Yuan   +6 more
openaire   +3 more sources