Results 81 to 90 of about 4,346 (168)

C5aR1-positive adipocytes mediate non-shivering thermogenesis in neonatal mice

iScience
Brown adipose tissue (BAT) plays an important role in maintaining body temperature in newborn mammals; however, its mechanisms remain poorly understood. Here, we report the identification of a special population of brown adipose tissue-derived stromal cells (ASCs) in neonatal mice that highly express CD45 and can be differentiated into adipocytes with ...
Huan-Yu Wang, Xue-Min Peng, Min Yang, Ying Weng, Xi Yang, Di Zhan, Qin Ning, Xiao-Ping Luo, Yong Chen   +8 more
openaire   +3 more sources

Correction to Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR 1) in lupus nephritis: A novel therapeutic target

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
wiley   +1 more source

The activation of complement C5a-C5aR1 axis in astrocytes facilitates the neuropathogenesis due to EV-A71 infection by upregulating CXCL1

Journal of Virology
Enterovirus A71 (EV-A71) is a common small RNA virus that is highly neuroinvasive. Emerging evidence indicates that the complement fragment C5a and its receptor C5aR1 are important drivers of neuroinflammation.
Peiyu Zhu, Wangquan Ji, Dong Li, Fang Wang, Tiantian Sun, Haiyan Yang, Shuaiyin Chen, Weiguo Zhang, Yuefei Jin, Guangcai Duan   +9 more
doaj   +1 more source

C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model

Nature Communications
Alzheimer’s disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. The complement pathway has been proposed as a therapeutic target.
Nicole D. Schartz, Heidi Y. Liang, Klebea Carvalho, Shu-Hui Chu, Adrian Mendoza-Arvilla, Tiffany J. Petrisko, Angela Gomez-Arboledas, Ali Mortazavi, Andrea J. Tenner   +8 more
doaj   +1 more source

C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment

Ecotoxicology and Environmental Safety
A mounting number of studies have been documenting strong pro-inflammatory and pro-fibrotic effects of carbon nanotube (CNT). However, the molecular mechanisms of single-walled CNT (SWCNT)-provoked lung injury remain to be elucidated.
Jiaojiao Zhu, Xiang Zhang, Lanlan Li, Hongxu Yang, Hang Liu, Danyang Wu, Zikai Liu, Bin Liu, Tong Shen   +8 more
doaj   +1 more source

Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI

Journal of Inflammation Research
Ying Han, Junrong Diao, Xinyan Wang, Shuai Zhang, Lina Yuan, Yaqiong Ping, Yunshan Zhang, Haining Luo Tianjin Central Hospital of Obstetrics and Gynecology/Nankai University Affiliated Maternity Hospital, Tianjin Key Laboratory of Human Development and ...
Han Y, Diao J, Wang X, Zhang S, Yuan L, Ping Y, Zhang Y, Luo H   +7 more
doaj  

Targeting C5AR1 disrupts complement-driven G0-phase maintenance and overcomes metabolic drug resistance in glioma

Journal of Translational Medicine
Background Glioblastoma (GBM) relapse and drug resistance are driven by a subset of quiescent, therapy-tolerant cells that persist in the G0 phase.
Yu Qian, Kai Zhao
doaj   +1 more source

Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia

npj Aging
Vascular dementia (VaD) is the second most common cause of dementia. Few bioinformatic analysis has been done to explore its biomarkers. This study aimed to excavate potential biomarkers for VaD using bioinformatic analysis and validate them at both animal and patient levels.
Yawen Xu, Hailing Zhang, Xuehao Jiao, Yanbo Zhang, Ge Yin, Cui Wang, Zengkan Du, Meng Liang, Xin Gao, Zhengsheng Gu, Yan Jiang, Bingying Du, Xiaoying Bi   +12 more
openaire   +2 more sources

Intratumoral C3ar/C5ar1 Antagonists Imbedded in an In Situ Forming Implant Can Robustly Suppress Solid Tumors. [PDF]

Cells
Choi YA, Konrad R, Pohlmann ES, Abenojar E, Exner A, Medof E.   +5 more
europepmc   +1 more source

The Complosome: An Emerging Intracellular Complement Network in Cancer Development and Therapy. [PDF]

Int J Mol Sci
Zadroga Ł, Lewandowski F, Bębnowska D, Majchrzak A, Czyż A, Niedźwiedzka-Rystwej P.   +5 more
europepmc   +1 more source