Results 81 to 90 of about 5,552 (193)

Role of the C5a/C5aR1 axis in bone cells

, 2023
The complement system is an important part of the innate immune system, which is activated by endogenous or exogenous pathogens. The main functions of the complement system are the direct destruction of pathogens and cellular components, opsonization and initiation of phagocytosis, and the induction of an inflammatory response.
openaire   +2 more sources

The C5a/C5aR1 Axis Contributes to the Pathogenesis of Acute Cystitis Through Enhancement of Adhesion and Colonization of Uropathogenic E. coli

Frontiers in Cellular and Infection Microbiology, 2022
Our previous work using a murine model of pyelonephritis demonstrated that the C5a/C5aR1 axis plays a pathogenic role in acute kidney infection. In this study, we report that the C5a/C5aR1 axis also plays a pathogenic role in acute bladder infection ...
Kun-Yi Wu, Bo Cao, Chun-Xuan Wang, Xue-Ling Yang, Shu-Juan Zhao, Teng-Yue Diao, Li-Rong Lin, Guo-Xiu Zhao, Wuding Zhou, Ju-Rong Yang, Ke Li   +10 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

C5aR1 Promotes Invasion, Metastasis, and Poor Prognosis in Cutaneous Squamous Cell Carcinoma

American Journal of Pathology
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and the metastatic from is associated with a poor prognosis. Here, the role of the complement C5a receptor C5aR1 was examined in the progression and metastasis of cSCC ...
L. Heiskanen, L. Nissinen, E. Siljamäki, J. Knuutila, T. Pellinen, M. Kallajoki, J. Heino, P. Riihilä, V. Kähäri   +8 more
semanticscholar   +1 more source

Complement receptor C5aR1 on osteoblasts regulates osteoclastogenesis in experimental postmenopausal osteoporosis

Frontiers in Endocrinology, 2022
In recent years, evidence has accumulated that the complement system, an integral part of innate immunity, may be involved in the regulation of bone homeostasis as well as inflammatory bone loss, for example, in rheumatoid arthritis and periodontitis.
Jasmin Maria Bülow, Nikolai Renz, Melanie Haffner-Luntzer, Verena Fischer, Astrid Schoppa, Jan Tuckermann, Jörg Köhl, Jörg Köhl, Markus Huber-Lang, Anita Ignatius   +9 more
openaire   +4 more sources

By Increasing the Expression and Activation of STAT3, Sustained C5a Stimulation Increases the Proliferation, Migration, and Invasion of RCC Cells and Promotes the Growth of Transgrafted Tumors

Cancer Management and Research, 2021
Jing-Min Zheng,1,* Han-Xi Zhou,1,* Hong-Yuan Yu,1,* Yu-Hui Xia,2 Qing-Xin Yu,2 Hang-Shuai Qu,1 Jia-Qian Bao1 1Department of Urology, Taizhou Hospital, Wenzhou Medical University, Linhai, Zhejiang, People’s Republic of China; 2Department of ...
Zheng JM, Zhou HX, Yu HY, Xia YH, Yu QX, Qu HS, Bao JQ   +6 more
doaj  

Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome

Frontiers in Immunology, 2018
Background and aims: Chronic ethanol exposure results in inflammation in adipose tissue; this response is associated with activation of complement as well as the development of alcohol-related liver disease (ALD).
Rebecca L. McCullough, Megan R. McMullen, Kyle L. Poulsen, Adam Kim, M. Edward Medof, Laura E. Nagy, Laura E. Nagy   +6 more
doaj   +1 more source

Unraveling the Plasma Extracellular Vesicles Proteome: Predictors of Resistance in Immunotherapy of Advanced Melanoma

International Journal of Cancer, Volume 159, Issue 11, Page 2824-2834, 1 December 2026.
ABSTRACT Despite substantial clinical benefit from immune checkpoint inhibitors (ICI), advanced melanoma remains challenging due to frequent treatment resistance. Resistance may be intrinsic (primary) or emerge over time (secondary). Biomarkers predicting distinct resistance phenotypes before therapy are lacking.
Julian Kött, Glenn Geidel, Carmen M. T. Roeper, Lucija Ačkar, Bente Siebels, Hannah Voß, Hartmut Schlüter, Michaela Schweizer, Kilian Müller, Alessandra Rünger, Tim Zell, Benjamin Deitert, Ali Zeinal‐Abedini, Isabel Heidrich, Stefan W. Schneider, Klaus Pantel, Daniel J. Smit, Christoffer Gebhardt   +17 more
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Disruption of the C5a/C5aR1 axis confers protection against hookworm infection in lung

Frontiers in Immunology
Hookworms are soil-transmitted parasitic nematodes that penetrate the host skin before migrating to the lungs. With an estimated 500-700 million people infected worldwide, hookworm infections are a neglected tropical disease and a significant cause of ...
Sarah Walachowski, Sarah Walachowski, Lucien Garo, Arjun Sharma, Arjun Sharma, Arjun Sharma, Archana Jayaraman, Jason Noon, Christoph Reinhardt, Markus Bosmann, Markus Bosmann   +10 more
doaj   +1 more source