Results 91 to 100 of about 4,493 (166)

C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model

Nature Communications
Alzheimer’s disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. The complement pathway has been proposed as a therapeutic target.
Nicole D. Schartz, Heidi Y. Liang, Klebea Carvalho, Shu-Hui Chu, Adrian Mendoza-Arvilla, Tiffany J. Petrisko, Angela Gomez-Arboledas, Ali Mortazavi, Andrea J. Tenner   +8 more
doaj   +1 more source

The activation of complement C5a-C5aR1 axis in astrocytes facilitates the neuropathogenesis due to EV-A71 infection by upregulating CXCL1

Journal of Virology
Enterovirus A71 (EV-A71) is a common small RNA virus that is highly neuroinvasive. Emerging evidence indicates that the complement fragment C5a and its receptor C5aR1 are important drivers of neuroinflammation.
Peiyu Zhu, Wangquan Ji, Dong Li, Fang Wang, Tiantian Sun, Haiyan Yang, Shuaiyin Chen, Weiguo Zhang, Yuefei Jin, Guangcai Duan   +9 more
doaj   +1 more source

Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI

Journal of Inflammation Research
Ying Han, Junrong Diao, Xinyan Wang, Shuai Zhang, Lina Yuan, Yaqiong Ping, Yunshan Zhang, Haining Luo Tianjin Central Hospital of Obstetrics and Gynecology/Nankai University Affiliated Maternity Hospital, Tianjin Key Laboratory of Human Development and ...
Han Y, Diao J, Wang X, Zhang S, Yuan L, Ping Y, Zhang Y, Luo H   +7 more
doaj  

C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment

Ecotoxicology and Environmental Safety
A mounting number of studies have been documenting strong pro-inflammatory and pro-fibrotic effects of carbon nanotube (CNT). However, the molecular mechanisms of single-walled CNT (SWCNT)-provoked lung injury remain to be elucidated.
Jiaojiao Zhu, Xiang Zhang, Lanlan Li, Hongxu Yang, Hang Liu, Danyang Wu, Zikai Liu, Bin Liu, Tong Shen   +8 more
doaj   +1 more source

Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia

npj Aging
Vascular dementia (VaD) is the second most common cause of dementia. Few bioinformatic analysis has been done to explore its biomarkers. This study aimed to excavate potential biomarkers for VaD using bioinformatic analysis and validate them at both animal and patient levels.
Yawen Xu, Hailing Zhang, Xuehao Jiao, Yanbo Zhang, Ge Yin, Cui Wang, Zengkan Du, Meng Liang, Xin Gao, Zhengsheng Gu, Yan Jiang, Bingying Du, Xiaoying Bi   +12 more
openaire   +2 more sources

Intratumoral C3ar/C5ar1 Antagonists Imbedded in an In Situ Forming Implant Can Robustly Suppress Solid Tumors. [PDF]

Cells
Choi YA, Konrad R, Pohlmann ES, Abenojar E, Exner A, Medof ME.   +5 more
europepmc   +1 more source

Exploring the Potential Value of Inflammatory Response-Associated Genes in Chronic Rhinosinusitis with Nasal Polyps: An Integrated Bioinformatics and Experimental Validation Analysis. [PDF]

J Inflamm Res
Hossen MDA, Liang S, Yan R, Zhu H, Yang S, Qin G.   +5 more
europepmc   +1 more source

GPR161 contributes to macrophage glycolytic reprogramming via targeting C5aR1 in acute lung injury. [PDF]

Cell Mol Biol Lett
Li YH, Yang X, Chen Y, Wang M, Shu H, Wan K, Sun DT, Yao N, Yang YL, Zhao F, Han BB, Yao C, Song B, Bao J, Sun GY, Li J, Li XF.   +16 more
europepmc   +1 more source

Unveiling natural anti-inflammatory compounds for sinusitis treatments by modulating FOXP3, C5aR1, and LIF. [PDF]

Front Immunol
Cao C, Hossen MA, Efti MS, Warda AA, AlJaouni SK, ElFar A, Lv C.   +6 more
europepmc   +1 more source

380 The role of C5a-C5aR1 axis in keratinocyte activation [PDF]

Journal of Investigative Dermatology, 2017
R. Shibuya, A. Kitoh, K. Kabashima
openaire   +1 more source