Results 91 to 100 of about 6,618 (201)

The effects of C5aR1 on leukocyte infiltration following pilocarpine‐induced status epilepticus [PDF]

Epilepsia, 2017
SummaryThis study aimed to determine the role C5aR1 plays in mediating immune responses acutely after pilocarpine‐induced status epilepticus (SE), specifically those of brain‐infiltrating leukocytes. Three days following pilocarpine SE, we determined by flow cytometry the brain immune cell phenotypes and measured key proinflammatory and ...
Benson, Melissa J., Manzanero, Silvia, Borges, Karin   +2 more
openaire   +3 more sources

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source

Spatial heterogeneity in microglia‐complement crosstalk: Implications for synaptic pruning in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Qiuyan Ye, Wei Gao, Jiaping Feng, Xue Li, Jianhui Li, Fengge Yang, Linqing Li, Mingsheng Zi, Xinkai Wu, Hainan Gao, Honglin Li   +10 more
wiley   +1 more source

Integrative cross‐tissue and spatially resolved single‐cell profiling uncovers tumour‐educated inflammatory remodelling of tissue‐resident macrophage ecosystem with immunotherapeutic prognostic significance in pan‐cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Pan‐cancer analysis reveals an inflammatory phenotype remodeling of tissue‐resident macrophages (iTRM) in the tumor microenvironment, which is associated with immunosuppression. Tissue‐resident macrophages and monocyte‐derived macrophages exhibit convergent differentiation toward a similar inflammatory phenotype. iTRM‐enriched ecosystems are associated
Weikai Wang, Zibin Chen, Yuhan Huang, Zhihao Hu, Peixin Zhu, Zhuoli Huang, Jingzhi Lv, Ziru Liao, Yuhui Zheng, Chen Wei, Baibing Guan, Yin Zeng, Xinyue Zhu, Yafei Yang, Guibo Li, Xin Jin, Xi Chen, Xiao Yang, Zikun Ma, Jianhua Yin   +19 more
wiley   +1 more source

Role of the C5a/C5aR1 axis in bone cells

, 2023
The complement system is an important part of the innate immune system, which is activated by endogenous or exogenous pathogens. The main functions of the complement system are the direct destruction of pathogens and cellular components, opsonization and initiation of phagocytosis, and the induction of an inflammatory response.
openaire   +2 more sources

C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

Acta Neuropathologica Communications, 2022
Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear.
Angela Gomez-Arboledas, Klebea Carvalho, Gabriela Balderrama-Gutierrez, Shu-Hui Chu, Heidi Yahan Liang, Nicole D. Schartz, Purnika Selvan, Tiffany J. Petrisko, Miranda A. Pan, Ali Mortazavi, Andrea J. Tenner   +10 more
doaj   +1 more source

The role of the complement system in traumatic brain injury: a review [PDF]

, 2018
Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of ...
A Alawieh, A Jauneau, A Kumar, Adnan Hammad, AG Therien, AH Stephan, AI Faden, AL Vescovi, B Oderfeld-Nowak, B Stevens, B-M Bellander, B-M Bellander, B-M Bellander, BJ Gabbe, BP Morgan, BP Morgan, C Cudrici, C Wang, CA Colton, CG Cochrane, D Cederberg, D Dupret, D Ricklin, D Shlosberg, DG Nicholls, DL Sewell, DN Abrous, DP Ankeny, DP Schafer, DT Fearon, E Makou, ED Ponomarev, EO Samstad, F Orsini, F Qiao, FH Brennan, G Arbore, G Winocur, GM Pasinetti, GT Manley, H Osaka, HD Manthey, HG Rus, HG Rus, HX Nguyen, I Leinhase, I Leinhase, I Leinhase, IP Karve, J Rogers, J van Beek, J van Beek, J Wetherington, JJ Ramirez, JL Cole, JR Dunkelberger, K Fluiter, K Färber, K Heese, K Järlestedt, K Pisalyaput, KA Kigerl, L Berliocchi, L Boos, L Longhi, L Longhi, L Soane, Laura Westacott, LG Coulthard, M Bénard, M Bénard, M Fosbrink, M Lévi-Strauss, M Moriyama, M Rancan, M-C Mathieu, Malik Zaben, MC Carroll, MC Carroll, MC Garrett, MD Saxe, ME Benoit, ME Medof, MJ Rutkowski, MK Liszewski, ML Pearn, MM Ruseva, N Sanai, N Shinjyo, NA Martin, O Butovsky, P Gasque, PF Stahel, PF Stahel, PF Stahel, PF Stahel, PH Yager, Q Shi, R Beschorner, R Knoth, RM Chesnut, RM Ransohoff, RS Ames, S Fumagalli, S Nataf, S Nataf, S Yang, SH Weerth, SK Ludwin, SL Kaczorowski, T Fujita, T Kossmann, TA Rupprecht, TJ Shors, U Amara, VM Holers, W Zheng, WH Kwan, X de la Rosa, X Jin, Y Chu, Y Rahpeymai, Y Xiong, YR Bogestål, Z You   +124 more
core   +1 more source

Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its anti‐inflammatory effect.
Xixi Liu, Chencheng Li, Jing Yang, Weiguang Zhang, Zhongxiao Hu, Xiaoli Zhang, Reaila Jianati, Fang Tian, Xingbin Dai, Zuqiong Xu, Biqing Chen, Xuejun Zhu   +11 more
wiley   +1 more source

GALDIERO is CO-FIRST AUTHOR. Phagocytes as Corrupted Policemen in Cancer-Related Inflammation [PDF]

, 2015
Inflammation is a key component of the tumor microenvironment. Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) are prototypic inflammatory cells in cancer-related inflammation.
Bonavita, Eduardo, Galdiero, MARIA ROSARIA, Jaillon, Sebastien, Mantovani, Alberto   +3 more
core   +1 more source

Complement receptors C5aR1 and C5aR2 differentially influence bone metabolism

, 2017
Objectives: Activation of the complement system, a crucial arm of innate immunity, leads to the generation of the anaphylatoxin C5a, acting via its receptors C5aR1 and C5aR2. C5aR1 has already been attributed an important role in bone development, regeneration and inflammation, as C5aR1 expression on[for full text, please go to the a.m. URL]
Hägele, Y, Bergdolt, S, Matthes, R, Kovtun, A, Ignatius, A   +4 more
openaire   +2 more sources