Results 111 to 120 of about 5,552 (193)

Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap

Journal of Molecular Histology
Sepsis has a systemic inflammatory response syndrome caused by infection. While neutrophils play contradictory roles in different stages of sepsis. Neutrophils have been proven to play an antibacterial role by producing neutrophil extracellular traps ...
Bin Shen, Qikai Shen, Qing-Qiu Zeng, Lingyan Zhang, Xiaofeng Li   +4 more
semanticscholar   +1 more source

Toxin protein LukS-PV targeting complement receptor C5aR1 inhibits cell proliferation in hepatocellular carcinoma via the HDAC7–Wnt/β-catenin axis

Journal of Biological Chemistry
Hepatocellular carcinoma (HCC) is one of the common malignant tumors. Complement system has become a new focus of cancer research by changing the biological behavior of cancer cells to influence the growth of cancer.
Lan Shi, Shan-Shan Zhang, Gan Liu, Zheng-Chao Nie, Peng-Sheng Ding, Wen-Jiao Chang, Yuan-Yuan Dai, Xiao-Ling Ma   +7 more
semanticscholar   +1 more source

Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI

Journal of Inflammation Research
Ying Han, Junrong Diao, Xinyan Wang, Shuai Zhang, Lina Yuan, Yaqiong Ping, Yunshan Zhang, Haining Luo Tianjin Central Hospital of Obstetrics and Gynecology/Nankai University Affiliated Maternity Hospital, Tianjin Key Laboratory of Human Development and ...
Han Y, Diao J, Wang X, Zhang S, Yuan L, Ping Y, Zhang Y, Luo H   +7 more
doaj  

Complement Proteins C1q-C5 as Context‑Dependent Regulators of Osteoblast Function and Fracture Healing: A Systematic Review. [PDF]

Orthop Rev (Pavia)
Counts PR, Baer TM, Viswanath O, Ganti L.   +3 more
europepmc   +1 more source

Complement tumor-crosstalk: the role of C5a receptors in urothelial carcinomas. [PDF]

Front Immunol
Lütje LS, Gruner C, Karsten CM, Merseburger AS, Roesch MC.   +4 more
europepmc   +1 more source

The C5a-C5aR1 axis facilitates blood-brain barrier disruption induced by EV-A71 infection through neutrophil activation. [PDF]

PLoS Pathog
Zhu P, Zeng X, Yuan X, Li Z, Ji W, Li D, Sun T, Yang H, Chen S, Long J, Wang F, Zhang Y, Shen A, Zhang W, Jin Y, Duan G.   +15 more
europepmc   +1 more source

Residue Interaction Network Reveals Allosteric Pathways Linking Orthosteric and Intracellular Sites in Class A GPCRs. [PDF]

J Chem Inf Model
Peter S, Chalhoub G, McCormick PJ, De Graaf C, Chen I, Bottegoni G.   +5 more
europepmc   +1 more source

Gut microbiota-derived metabolites target C5AR1/KDM2A/HCAR3 axis in inflammatory bowel disease: a multi-machine learning algorithms and molecular docking study. [PDF]

Front Cell Infect Microbiol
Hu S, Fu L, Gao J, Guo Q, Han S.
europepmc   +1 more source

Complement-Targeted Therapies in Glioblastoma: A Systematic Review. [PDF]

Biomedicines
Walton CM, Strickland BA.
europepmc   +1 more source

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model. [PDF]

Glia
Petrisko TJ, Chu SH, Gomez-Arboledas A, Zhang B, Tenner AJ.   +4 more
europepmc   +1 more source