Results 111 to 120 of about 6,618 (201)

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. [PDF]

, 2019
Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown.
Edgerton, V Reggie, Hara, Masamitsu, Harimaya, Katsumi, Inoue, Kazuhide, Iwamoto, Yukihide, Kijima, Ken, Kobayakawa, Kazu, Kubota, Kensuke, Masuda, Takahiro, Matsumoto, Yoshihiro, Nakashima, Yasuharu, Ohkawa, Yasuyuki, Okada, Seiji, Ozato, Keiko, Saito, Takeyuki, Tamaru, Tetsuya, Tamura, Tomohiko, Tsuda, Makoto, Yokota, Kazuya, Yoshizaki, Shingo   +19 more
core   +1 more source

Epithelial C5aR1 Signaling Enhances Uropathogenic Escherichia coli Adhesion to Human Renal Tubular Epithelial Cells

Frontiers in Immunology, 2018
Recent work in a murine model of ascending urinary tract infection has suggested that C5a/C5aR1 interactions play a pathogenic role in the development of renal infection through enhancement of bacterial adhesion/colonization to renal tubular epithelial ...
Yun Song, Kun-Yi Wu, Weiju Wu, Zhao-Yang Duan, Ya-Feng Gao, Liang-Dong Zhang, Tie Chong, Malgorzata A. Garstka, Wuding Zhou, Ke Li   +9 more
doaj   +1 more source

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. [PDF]

, 2018
Genome-wide investigations of host-pathogen interactions are often limited by analyses of mixed populations of infected and uninfected cells, which lower sensitivity and accuracy.
Benner, Christopher, Branche, Emilie, Carlin, Aaron F, Glass, Christopher K, Heinz, Sven, Ley, Klaus, Shresta, Sujan, Suarez-Amaran, Lester, Viramontes, Karla M, Vizcarra, Edward A   +9 more
core  

Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4

Cell Death and Disease
Glioblastoma (GBM) is the most common primary intracranial malignant tumor. Recent literature suggests that induction of programmed death has become a mainstream cancer treatment strategy, with ferroptosis being the most widely studied mode.
Xiangrui Meng, Zixuan Wang, Qingqing Yang, Yawei Liu, Yisu Gao, Hefei Chen, Ang Li, Rongqing Li, Jun Wang, Guan Sun   +9 more
doaj   +1 more source

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. [PDF]

, 2019
Many risk genes for the development of Alzheimer's disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival.
Bollag, Gideon, Broome, Stephanie, Burton, Elizabeth A, Crapser, Joshua, Green, Kim N, Habets, Gaston, Hohsfield, Lindsay A, Ibrahim, Prabha, Lin, Jack, Nespi, Marika, Phan, Nicole Y, Rymar, Andrey, Severson, Paul L, Singh, Parmveer, Spangenberg, Elizabeth, Spevak, Wayne, Tsang, Garson, Walters, Jason, West, Brian L, Zhang, Chao, Zhang, Jiazhong, Zhang, Ying   +21 more
core  

Conformational variants of the ternary complex of C5a, C5aR1, and G-protein

Journal of Biomolecular Structure and Dynamics
The complement component fragment 5a (C5a) binds and activates two complement receptors like C5aR1 and C5aR2, which play a significant role in orchestrating the proinflammatory function of C5a in tissues through the recruitment of heterotrimeric G-proteins and β-arrestins.
Pulkit Kr, Gupta, Aditi, Singh, Soumendra, Rana   +2 more
openaire   +2 more sources

C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis [PDF]

, 2017
Adrian W. S. Ho, Alessandra Mortellaro, Baalasubramanian Sivasankar, Federica Laudisi, Gim Gee Teng, Hanif J. Khameneh, Heidi Derks, Matheswaran Kandasamy   +7 more
core   +1 more source

The Cutaneous Lesions of Dioxin Exposure: Lessons from the Poisoning of Victor Yushchenko [PDF]

, 2017
Several million people are exposed to dioxin and dioxin-like compounds, primarily through food consumption. Skin lesions historically called "chloracne” are the most specific sign of abnormal dioxin exposure and classically used as a key marker in humans.
Barde, Caroline, Becker, Minerva, Carraux, Pierre, Descombes, Patrick, Fontao, Fabienne, Fontao, Lionel, Kaya, Guerkan, Mottu, Florence, Pardo, Bruno, Pham, Xuan-Cuong, Saurat, Jean-Hilaire, Saxer-Sekulic, Nikolina, Schaad, Olivier, Schmid, Peter, Sorg, Olivier, Zennegg, Markus   +15 more
core  

The activation of complement C5a-C5aR1 axis in astrocytes facilitates the neuropathogenesis due to EV-A71 infection by upregulating CXCL1

Journal of Virology
Enterovirus A71 (EV-A71) is a common small RNA virus that is highly neuroinvasive. Emerging evidence indicates that the complement fragment C5a and its receptor C5aR1 are important drivers of neuroinflammation.
Peiyu Zhu, Wangquan Ji, Dong Li, Fang Wang, Tiantian Sun, Haiyan Yang, Shuaiyin Chen, Weiguo Zhang, Yuefei Jin, Guangcai Duan   +9 more
doaj   +1 more source

C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model

Nature Communications
Alzheimer’s disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. The complement pathway has been proposed as a therapeutic target.
Nicole D. Schartz, Heidi Y. Liang, Klebea Carvalho, Shu-Hui Chu, Adrian Mendoza-Arvilla, Tiffany J. Petrisko, Angela Gomez-Arboledas, Ali Mortazavi, Andrea J. Tenner   +8 more
doaj   +1 more source