Results 1 to 10 of about 16,656 (99)

New insights for C5a and C5a receptors in sepsis [PDF]

Frontiers in Immunology, 2012
The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions. There is strong evidence for complement activation including elevated plasma level of C5a in humans and animals with sepsis.
Yan, Chunguang, Gao, Hongwei
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The role of C5a receptors in autoimmunity

Immunobiology, 2023
The complement system is an essential component of the innate immune response and plays a vital role in host defense and inflammation. Dysregulation of the complement system, particularly involving the anaphylatoxin C5a and its receptors (C5aR1 and C5aR2), has been linked to several autoimmune diseases, indicating the potential for targeted therapies ...
Jovan, Schanzenbacher, Katja, Hendrika Kähler, Evelyn, Mesler, Marie, Kleingarn, Christian, Marcel Karsten, Daniel, Leonard Seiler   +5 more
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Functions of C5a receptors [PDF]

Journal of Molecular Medicine, 2009
The split product of the complement protein, C5, is C5a and is an extremely potent pro-inflammatory peptide that interacts with two C5a receptors, C5aR and C5L2, present on surfaces of phagocytes as well as other cell types. The former is a well-established receptor that initiates G-protein-coupled signaling via mitogen-activated protein kinase ...
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C5a receptor and thymocyte apoptosis in sepsis [PDF]

The FASEB Journal, 2002
ABSTRACT In sepsis, apoptosis occurs in many different organs. The mediators responsible for induction of apoptosis are not clearly known, although there are some suggestions that C5a and the C5a receptor (C5aR) might be directly linked to apoptosis.
Riedemann, Niels C., Guo, Ren‐feng, Laudes, Ines J., Keller, Katie, Sarma, Vidya J., Padgaonkar, Vaishalee, Zetoune, Firas S., Ward, Peter A.   +7 more
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The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.

Journal of Biological Chemistry, 1994
The binding domain of the human C5a receptor consists of two distinct and physically separable subsites. One of these sites binds the C-terminal 8 amino acids of C5a and is as yet undefined, while the second site lies in the N terminus of the receptor and interacts with the core of C5a. Two deletion mutants were prepared to probe the importance of this
J A, DeMartino, G, Van Riper, S J, Siciliano, C J, Molineaux, Z D, Konteatis, H, Rosen, M S, Springer   +6 more
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Increased C5a receptor expression in sepsis [PDF]

Journal of Clinical Investigation, 2002
Excessive production of the complement activation product C5a appears to be harmful during the development of sepsis in rodents. Little is known about the role of the C5a receptor (C5aR) and its presence in different organs during sepsis. Using the cecal ligation/puncture (CLP) model in mice, we show here that C5aR immunoreactivity was strikingly ...
Niels C, Riedemann, Ren-Feng, Guo, Thomas A, Neff, Ines J, Laudes, Katie A, Keller, Vidya J, Sarma, Maciej M, Markiewski, Dimitrios, Mastellos, Christoph W, Strey, Carl L, Pierson, John D, Lambris, Firas S, Zetoune, Peter A, Ward   +12 more
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Pharmacological characterization of antagonists of the C5a receptor [PDF]

British Journal of Pharmacology, 1999
Potent and highly selective small molecule antagonists have recently been developed by us for C5a receptors (C5aR) on human polymorphonuclear leukocytes (PMN). In this study we compared a new cyclic antagonist, F‐[OPdChaWR], with an acyclic derivative, MeFKPdChaWr, for their capacities to bind to C5aR on human PMN and human umbilical artery membranes.
Paczkowski, NJ, Finch, AM, Whitmore, JB, Short, AJ, Wong, AK, Monk, PN, Cain, SA, Fairlie, DP, Taylor, SM   +8 more
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Functional roles for C5a receptors in sepsis [PDF]

Nature Medicine, 2008
The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77), especially of C5l2, which was originally termed a 'default receptor', remains a controversial topic. Here we investigated the role of each receptor in the setting of cecal ligation and puncture-induced sepsis by using antibody-induced blockade of C5a receptors and ...
Daniel, Rittirsch, Michael A, Flierl, Brian A, Nadeau, Danielle E, Day, Markus, Huber-Lang, Charles R, Mackay, Firas S, Zetoune, Norma P, Gerard, Katherine, Cianflone, Jörg, Köhl, Craig, Gerard, J Vidya, Sarma, Peter A, Ward   +12 more
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Cloning and characterization of the guinea pig C5a anaphylatoxin receptor: interspecies diversity among the C5a receptors [PDF]

International Immunology, 1998
The anaphylatoxin C5a receptor (C5aR, CD88 in man) plays a prominent role in mediating inflammatory and host defense processes. Direct evidence of C5aR involvement in host defense mechanisms was demonstrated recently using C5aR knockout mice. Mice deficient in C5aR were unable to clear intrapulmonary-instilled bacteria. The guinea pig system is perhaps
Y, Fukuoka, J A, Ember, A, Yasui, T E, Hugli   +3 more
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Chimeric Receptors of the Human C3a Receptor and C5a Receptor (CD88) [PDF]

Journal of Biological Chemistry, 1999
Chimeras were generated between the human anaphylatoxin C3a and C5a receptors (C3aR and C5aR, respectively) to define the structural requirements for ligand binding and discrimination. Chimeric receptors were generated by systematically exchanging between the two receptors four receptor modules (the N terminus, transmembrane regions 1 to 4, the second ...
T, Crass, R S, Ames, H M, Sarau, M A, Tornetta, J J, Foley, J, Köhl, A, Klos, W, Bautsch   +7 more
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