Results 31 to 40 of about 17,322 (203)

The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.

Journal of Biological Chemistry, 1994
The binding domain of the human C5a receptor consists of two distinct and physically separable subsites. One of these sites binds the C-terminal 8 amino acids of C5a and is as yet undefined, while the second site lies in the N terminus of the receptor and interacts with the core of C5a. Two deletion mutants were prepared to probe the importance of this
J A, DeMartino, G, Van Riper, S J, Siciliano, C J, Molineaux, Z D, Konteatis, H, Rosen, M S, Springer   +6 more
openaire   +2 more sources

Increased C5a receptor expression in sepsis [PDF]

Journal of Clinical Investigation, 2002
Excessive production of the complement activation product C5a appears to be harmful during the development of sepsis in rodents. Little is known about the role of the C5a receptor (C5aR) and its presence in different organs during sepsis. Using the cecal ligation/puncture (CLP) model in mice, we show here that C5aR immunoreactivity was strikingly ...
Niels C, Riedemann, Ren-Feng, Guo, Thomas A, Neff, Ines J, Laudes, Katie A, Keller, Vidya J, Sarma, Maciej M, Markiewski, Dimitrios, Mastellos, Christoph W, Strey, Carl L, Pierson, John D, Lambris, Firas S, Zetoune, Peter A, Ward   +12 more
openaire   +2 more sources

Bidirectional Crosstalk between C5a Receptors and the NLRP3 Inflammasome in Macrophages and Monocytes

Mediators of Inflammation, 2016
C5a is an inflammatory mediator generated by complement activation that positively regulates various arms of immune defense, including Toll-like receptor 4 (TLR4) signaling.
Mikel D. Haggadone, Jamison J. Grailer, Fatemeh Fattahi, Firas S. Zetoune, Peter A. Ward   +4 more
doaj   +1 more source

Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis

Thrombosis Journal, 2022
Background Thrombotic events cannot be completely prevented by antithrombotics, implicating a therapeutic gap due to inflammation, a not yet sufficiently addressed mechanism.
Yejia Chen, Xiaobo Li, Xinxin Lin, Hongbin Liang, Xuewei Liu, Xinlu Zhang, Qiuxia Zhang, Fengyun Zhou, Chen Yu, Li Lei, Jiancheng Xiu   +10 more
doaj   +1 more source

Pharmacological characterization of antagonists of the C5a receptor [PDF]

British Journal of Pharmacology, 1999
Potent and highly selective small molecule antagonists have recently been developed by us for C5a receptors (C5aR) on human polymorphonuclear leukocytes (PMN). In this study we compared a new cyclic antagonist, F‐[OPdChaWR], with an acyclic derivative, MeFKPdChaWr, for their capacities to bind to C5aR on human PMN and human umbilical artery membranes.
Paczkowski, NJ, Finch, AM, Whitmore, JB, Short, AJ, Wong, AK, Monk, PN, Cain, SA, Fairlie, DP, Taylor, SM   +8 more
openaire   +5 more sources

Complement C5a Implication in Axonal Growth After Injury

Cells
Complement C5a protein has been shown to play a major role in tissue regeneration through interaction with its receptor (C5aR) on target cells. Expression of this receptor has been reported in the nervous system which, upon injury, has no treatment to ...
Aurélie Cotten, Charlotte Jeanneau, Patrick Decherchi, Imad About   +3 more
doaj   +1 more source

Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.

PLoS ONE, 2012
The complement anaphylatoxin C5a has a pathogenetic role in endotoxin-induced lung inflammatory injury by regulating phagocytic cell migration and activation.
Kurt Bachmaier, Edgar Guzman, Takeshi Kawamura, Xiaopei Gao, Asrar B Malik   +4 more
doaj   +1 more source

Functional roles for C5a receptors in sepsis [PDF]

Nature Medicine, 2008
The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77), especially of C5l2, which was originally termed a 'default receptor', remains a controversial topic. Here we investigated the role of each receptor in the setting of cecal ligation and puncture-induced sepsis by using antibody-induced blockade of C5a receptors and ...
Daniel, Rittirsch, Michael A, Flierl, Brian A, Nadeau, Danielle E, Day, Markus, Huber-Lang, Charles R, Mackay, Firas S, Zetoune, Norma P, Gerard, Katherine, Cianflone, Jörg, Köhl, Craig, Gerard, J Vidya, Sarma, Peter A, Ward   +12 more
openaire   +2 more sources

Cloning and characterization of the guinea pig C5a anaphylatoxin receptor: interspecies diversity among the C5a receptors [PDF]

International Immunology, 1998
The anaphylatoxin C5a receptor (C5aR, CD88 in man) plays a prominent role in mediating inflammatory and host defense processes. Direct evidence of C5aR involvement in host defense mechanisms was demonstrated recently using C5aR knockout mice. Mice deficient in C5aR were unable to clear intrapulmonary-instilled bacteria. The guinea pig system is perhaps
Y, Fukuoka, J A, Ember, A, Yasui, T E, Hugli   +3 more
openaire   +2 more sources

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source