Results 31 to 40 of about 1,253,157 (246)

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

Acta Neuropathologica Communications, 2018
The complement system is a key driver of neuroinflammation. Activation of complement by all pathways, results in the formation of the anaphylatoxin C5a and the membrane attack complex (MAC).
Iliana Michailidou, Aldo Jongejan, Jeroen P. Vreijling, Theodosia Georgakopoulou, Marit B. de Wissel, Ruud A. Wolterman, Patrick Ruizendaal, Ngaisah Klar-Mohamad, Anita E. Grootemaat, Daisy I. Picavet, Vinod Kumar, Cees van Kooten, Trent M. Woodruff, B. Paul Morgan, Nicole N. van der Wel, Valeria Ramaglia, Kees Fluiter, Frank Baas   +17 more
doaj   +1 more source

Pro-inflammatory regulatory mechanism of C5a/C5aR pathway in GCRV-infected grass carp (Ctenopharyngodon idella)

Aquaculture Reports, 2023
Death of grass carp (Ctenopharyngodon idella) caused by grass carp reovirus (GCRV) infection severely restricts the development of the grass carp industry.
Baohong Xu, Hang Su, Changjun Chen, Qiaolin Liu, Tiaoyi Xiao, Yi Liu, Zhao Lv, Hongquan Wang, Zheyu Wen   +8 more
doaj   +1 more source

Cultured human glomerular mesangial cells express the C5a receptor [PDF]

, 1998
Cultured human glomerular mesangial cells express the C5a receptor.BackgroundWhile the association of complement activation and glomerulonephritis has been recognized for decades, the pathogenic mechanisms of complement-mediated glomerular damage are ...
Davis, Alvin E., Braun, Michael
core   +1 more source

Bidirectional Crosstalk between C5a Receptors and the NLRP3 Inflammasome in Macrophages and Monocytes

Mediators of Inflammation, 2016
C5a is an inflammatory mediator generated by complement activation that positively regulates various arms of immune defense, including Toll-like receptor 4 (TLR4) signaling.
Mikel D. Haggadone, Jamison J. Grailer, Fatemeh Fattahi, Firas S. Zetoune, Peter A. Ward   +4 more
doaj   +1 more source

Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand

, 1999
Despite the expression of only one type of receptor, there is great variation in the ability of different cell types to discriminate between C5a and its more stable metabolite, C5a des Arg74. The mechanism that underlies this phenomenon is not understood
Monk, Peter N., Crass, Torsten, Pease, James E., Cain, Stuart A.; id_orcid, Bautsch, Wilfried   +4 more
core   +1 more source

Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis

Thrombosis Journal, 2022
Background Thrombotic events cannot be completely prevented by antithrombotics, implicating a therapeutic gap due to inflammation, a not yet sufficiently addressed mechanism.
Yejia Chen, Xiaobo Li, Xinxin Lin, Hongbin Liang, Xuewei Liu, Xinlu Zhang, Qiuxia Zhang, Fengyun Zhou, Chen Yu, Li Lei, Jiancheng Xiu   +10 more
doaj   +1 more source

Complement C5a Implication in Axonal Growth After Injury

Cells
Complement C5a protein has been shown to play a major role in tissue regeneration through interaction with its receptor (C5aR) on target cells. Expression of this receptor has been reported in the nervous system which, upon injury, has no treatment to ...
Aurélie Cotten, Charlotte Jeanneau, Patrick Decherchi, Imad About   +3 more
doaj   +1 more source

Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.

PLoS ONE, 2012
The complement anaphylatoxin C5a has a pathogenetic role in endotoxin-induced lung inflammatory injury by regulating phagocytic cell migration and activation.
Kurt Bachmaier, Edgar Guzman, Takeshi Kawamura, Xiaopei Gao, Asrar B Malik   +4 more
doaj   +1 more source

Unidirectional heterologous receptor desensitization between both the fMLP and C5a receptor and the IL‐8 receptor [PDF]

, 1996
During inflammation neutrophils receive multiple signals that are integrated, allowing a single modified response. One mechanism for this discrimination is receptor desensitization, a process whereby ligand‐receptor binding is disassociated from cell ...
Blackwood, R. Alexander, Hartiala, Kaija T., Kwoh, Ely E., Brower, Ruth C., Ruth C Brower, R Alexander Blackwood, Kaija T Hartiala, Ely E Kwoh, Transue, Amy T., Amy T Transue   +9 more
core   +1 more source

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source