Results 21 to 30 of about 1,253,157 (246)

Important roles of C5a and C5aR in tumor development and cancer treatment [PDF]

E3S Web of Conferences, 2019
The complement system is part of the body's innate defense immune system, which can identify and eliminate invasive pathogenic microorganisms to maintain normal life activities.
Yuxuan Wang
doaj   +1 more source

Activated complement protein C5a does not affect brain-derived endothelial cell viability and zonula occludens-1 levels following oxygen-glucose deprivation

Brain Circulation, 2017
BACKGROUND AND PURPOSE: Ischemic brain injury induces both functional and structural disarray affecting the blood–brain barrier (BBB) which in return aggravates stroke outcomes.
Aren Khoyetsyan, Rachid Kacimi, Gohar Tsakanova, Anna Boyajyan, Arsen Arakelyan, Midori A Yenari   +5 more
doaj   +1 more source

TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2 [PDF]

, 2011
TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the pro-inflammatory complement peptide C5a (C5aR/CD88), and regulation of TLR-induced pro-inflammatory ...
Morgan, Bryan Paul, Judith Hall, Mario O. Labéta, Colmont, Chantal Sophie, Anne-Catherine Raby, Nicholas Topley, Shah, Sanjoy, Laumonnier, Yves, Barbara Coles, Hall, Judith Elizabeth, Holst, Benjamin, Jörg Köhl, B. Paul Morgan, Raby, Anne-Catherine, Labeta, Mario Oscar, James Davies, Yves Laumonnier, Benjamin Holst, Coles, Barbara, Köhl, Jörg, Davies, James Anthony, Topley, Nicholas, Chantal Colmont, Sanjoy Shah   +23 more
core   +1 more source

The relationship of anti-phospholipase A2 receptor antibody and C5a complement with disease activity and short-term outcome in idiopathic membranous nephropathy

Journal of the Formosan Medical Association, 2019
Background: The binding of anti-phospholipase A2 receptor (anti-PLA2R) antibody to podocyte and complement activation is the mechanisms of idiopathic membranous nephropathy (IMN).
Jyun Ni Chi, Tai Shuan Lai, Ching Fang Wu, Tian Yi Fu, Yu Hsiang Chou, Yen Ling Chiu, Wei Chou Lin, Wen Chih Chiang, Yung Ming Chen, Ming Shiou Wu   +9 more
doaj   +1 more source

Association of C5a/C5aR pathway to activate ERK1/2 and p38 MAPK in acute kidney injury – a mouse model

Romanian Journal of Laboratory Medicine, 2022
Acute inflammation is accompanied by complement system activation and inflammatory cell accumulation. Acute kidney injury (AKI) is one of the common clinical symptoms, it is not clear whether complement system-mediated signaling pathway is involved. This
Zhang Zeying
doaj   +1 more source

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

Angewandte Chemie, EarlyView.
Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang, Jingqu Chen, Siying Chen, Binsha Peng, Zhifeng Zhou, Ling Zhang, Rui Xie, Xiaojie Ju, Wei Wang, Dawei Pan, Liangyin Chu, Frank Caruso, Zhuang Liu   +12 more
wiley   +2 more sources

Expression of C5a receptor in mouse brain: Role in signal transduction and neurodegeneration

, 1999
In this study we explored the potential role of the complement derived anaphylatoxin C5a and the expression of its receptor in mouse brain. Using in situ hybridization, we found that C5a receptor messenger RNA is expressed in mouse brain.
Gerard, C., Hoepken, U.E., Lu, Wanhua, Pasinetti, G.M., H. Osaka, C. Gerard, A. McGinty, B. Lu, McGinty, Ann, Osaka, H., Höpken, U.E., Lu, B., G.M. Pasinetti, U.E. Höpken, McGinty, A.   +14 more
core   +3 more sources

Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a.

PLoS ONE, 2016
Netrin-1, acting at its cognate receptor UNC5b, has been previously demonstrated to inhibit CC chemokine-induced immune cell migration. In line with this, we found that netrin-1 was able to inhibit CCL2-induced migration of bone marrow derived ...
Lewis Taylor, Maximillian Hugo Brodermann, David McCaffary, Asif Jilani Iqbal, David R Greaves   +4 more
doaj   +1 more source

NOD2-mediated suppression of CD55 on neutrophils enhances C5a generation during polymicrobial sepsis. [PDF]

PLoS Pathogens, 2013
Nucleotide-binding oligomerization domain (NOD) 2 is a cytosolic protein that plays a defensive role in bacterial infection by sensing peptidoglycans. C5a, which has harmful effects in sepsis, interacts with innate proteins.
Sae Jin Oh, Ji Hyung Kim, Doo Hyun Chung
doaj   +1 more source

Leukocyte C5a receptor modulation during hemodialysis [PDF]

, 1987
Leukocyte C5a receptor modulation during hemodialysis. Exposure of blood to hemodialysis (HD) membranes results in the activation of the complement system.
Chenoweth, Dennis E., Sharon L. Lewis, Dennis E. Chenoweth, Van Epps, Dennis E., Lewis, Sharon L., Dennis E. Van Epps   +5 more
core   +1 more source