Results 21 to 30 of about 1,255,490 (262)

The interaction between circulating complement proteins and cutaneous microvascular endothelial cells in the development of childhood Henoch-Schönlein Purpura. [PDF]

PLoS ONE, 2015
In addition to IgA, the deposition of complement (C)3 in dermal vessels is commonly found in Henoch-Schönlein purpura (HSP). The aim of this study is to elucidate the role of circulating complement proteins in the pathogenesis of childhood HSP.Plasma ...
Yao-Hsu Yang, I-Jung Tsai, Chun-Jung Chang, Ya-Hui Chuang, Hui-Yao Hsu, Bor-Luen Chiang   +5 more
doaj   +1 more source

Important roles of C5a and C5aR in tumor development and cancer treatment [PDF]

E3S Web of Conferences, 2019
The complement system is part of the body's innate defense immune system, which can identify and eliminate invasive pathogenic microorganisms to maintain normal life activities.
Yuxuan Wang
doaj   +1 more source

7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor.

PLoS ONE, 2017
We investigated effects of 7-oxygenated cholesterol derivatives present in atherosclerotic lesions, 7α-hydroxycholesterol (7αOHChol), 7β-hydroxycholesterol (7βOHChol), and 7-ketocholesterol (7K), on IL-8 expression.
Hyok-Rae Cho, Yonghae Son, Sun-Mi Kim, Bo-Young Kim, Seong-Kug Eo, Young Chul Park, Koanhoi Kim   +6 more
doaj   +1 more source

Activated complement protein C5a does not affect brain-derived endothelial cell viability and zonula occludens-1 levels following oxygen-glucose deprivation

Brain Circulation, 2017
BACKGROUND AND PURPOSE: Ischemic brain injury induces both functional and structural disarray affecting the blood–brain barrier (BBB) which in return aggravates stroke outcomes.
Aren Khoyetsyan, Rachid Kacimi, Gohar Tsakanova, Anna Boyajyan, Arsen Arakelyan, Midori A Yenari   +5 more
doaj   +1 more source

The relationship of anti-phospholipase A2 receptor antibody and C5a complement with disease activity and short-term outcome in idiopathic membranous nephropathy

Journal of the Formosan Medical Association, 2019
Background: The binding of anti-phospholipase A2 receptor (anti-PLA2R) antibody to podocyte and complement activation is the mechanisms of idiopathic membranous nephropathy (IMN).
Jyun Ni Chi, Tai Shuan Lai, Ching Fang Wu, Tian Yi Fu, Yu Hsiang Chou, Yen Ling Chiu, Wei Chou Lin, Wen Chih Chiang, Yung Ming Chen, Ming Shiou Wu   +9 more
doaj   +1 more source

Association of C5a/C5aR pathway to activate ERK1/2 and p38 MAPK in acute kidney injury – a mouse model

Romanian Journal of Laboratory Medicine, 2022
Acute inflammation is accompanied by complement system activation and inflammatory cell accumulation. Acute kidney injury (AKI) is one of the common clinical symptoms, it is not clear whether complement system-mediated signaling pathway is involved. This
Zhang Zeying
doaj   +1 more source

Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a.

PLoS ONE, 2016
Netrin-1, acting at its cognate receptor UNC5b, has been previously demonstrated to inhibit CC chemokine-induced immune cell migration. In line with this, we found that netrin-1 was able to inhibit CCL2-induced migration of bone marrow derived ...
Lewis Taylor, Maximillian Hugo Brodermann, David McCaffary, Asif Jilani Iqbal, David R Greaves   +4 more
doaj   +1 more source

NOD2-mediated suppression of CD55 on neutrophils enhances C5a generation during polymicrobial sepsis. [PDF]

PLoS Pathogens, 2013
Nucleotide-binding oligomerization domain (NOD) 2 is a cytosolic protein that plays a defensive role in bacterial infection by sensing peptidoglycans. C5a, which has harmful effects in sepsis, interacts with innate proteins.
Sae Jin Oh, Ji Hyung Kim, Doo Hyun Chung
doaj   +1 more source

TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2 [PDF]

, 2011
TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the pro-inflammatory complement peptide C5a (C5aR/CD88), and regulation of TLR-induced pro-inflammatory ...
Morgan, Bryan Paul, Judith Hall, Mario O. Labéta, Colmont, Chantal Sophie, Anne-Catherine Raby, Nicholas Topley, Shah, Sanjoy, Laumonnier, Yves, Barbara Coles, Hall, Judith Elizabeth, Holst, Benjamin, Jörg Köhl, B. Paul Morgan, Raby, Anne-Catherine, Labeta, Mario Oscar, James Davies, Yves Laumonnier, Benjamin Holst, Coles, Barbara, Köhl, Jörg, Davies, James Anthony, Topley, Nicholas, Chantal Colmont, Sanjoy Shah   +23 more
core   +1 more source

The free fatty acid 2 receptor regulates C5a induced neutrophil superoxide production and its sensitivity to inhibition by the antagonist avacopan

Frontiers in Immunology
IntroductionReceptor transactivation is a novel signaling mechanism used by several different neutrophil G protein-coupled receptors (GPCRs) to activate an allosterically modulated receptor that recognizes short chain free fatty acids.
Zahra Khan, Zahra Khan, Neele K. Levin, Claes Dahlgren, Martina Sundqvist, Fariha Khan, Huamei Forsman, Huamei Forsman, Lena Björkman   +8 more
doaj   +1 more source