Results 41 to 50 of about 1,253,157 (246)

Characterisation of C5a receptor agonists from phage display libraries

, 2003
C5a des-Arg74 has a 10- to 100-fold lower receptor binding affinity than intact C5a and is only a partial agonist. We have used phage display selection from randomly mutated C5a des-Arg74 libraries to isolate variant proteins that can activate C5a ...
Monk, Peter N., Higginbottom, Adrian, Cain, Stuart A.; id_orcid   +2 more
core   +1 more source

The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.

Journal of Biological Chemistry, 1994
The binding domain of the human C5a receptor consists of two distinct and physically separable subsites. One of these sites binds the C-terminal 8 amino acids of C5a and is as yet undefined, while the second site lies in the N terminus of the receptor and interacts with the core of C5a. Two deletion mutants were prepared to probe the importance of this
J A, DeMartino, G, Van Riper, S J, Siciliano, C J, Molineaux, Z D, Konteatis, H, Rosen, M S, Springer   +6 more
openaire   +2 more sources

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Studies on the role of inflammation and stem cells in cardiac ischaemic injury [PDF]

, 2008
The regenerative capacity of human myocardium is unable to compensate adequately forth significant loss of heart muscle that occurs in acute myocardial infarction (Ml).
Ahmed, Ishtiaq M., Ahmed, Ishtiaq M
core  

Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor

, 2016
This study presents the 3D model of the complex between the anaphylatoxin C5a and its specific receptor, C5aR. This is the first 3D model of a G-protein-coupled receptor (GPCR) complex with a peptide ligand deduced by a molecular modeling procedure ...
Garland R. Marshall (727036), Thomas J. Baranski (104900), Gregory V. Nikiforovich (2450236)   +2 more
core   +1 more source

Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis

Frontiers in Cellular Neuroscience, 2023
BackgroundThe extent of cortical pathology is an important determinant of multiple sclerosis (MS) severity. Cortical demyelination and neurodegeneration are related to inflammation of the overlying leptomeninges, a more inflammatory CSF milieu and with ...
Rhian Evans, Lewis M. Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I. Rees, Denise Fitzgerald, B. Paul Morgan, James W. Neal, Owain W. Howell   +11 more
doaj   +1 more source

Wheat germ agglutinin inhibits the C5a receptor interaction: implications for receptor microheterogeneity and ligand binding site

, 1992
Wheat germ agglutinin (WGA) has been shown to inhibit the interaction of C5a with the C5a receptor on both polymorphonuclear neutrophils (PMNs) and the histiocytic cell line U937.
Richard J Johnson, Dennis E van Epps, Stacy Simpson, Dennis E Chenoweth   +3 more
core   +1 more source

Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis [PDF]

, 2004
Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis. Once initial host barrier systems have been breached by these pathogens, the innate immune system provides the next ...
Bannerman, Douglas, Goff, JP, Goff, Jesse P, Lippolis, JD, John D. Lippolis, Paape, Max, Bannerman, Douglas D, Paape, Max J, Kimura, K, Jayne C. Hope, Hope, Jayne C, Kimura, Kayoko, Lippolis, John D, Douglas D. Bannerman, Max J. Paape, Lippolis, John, Hope, Jayne, Kayoko Kimura, Hope, Jayne; id_orcid, Jesse P. Goff, Goff, Jesse   +20 more
core   +1 more source

Above and beyond C5a Receptor Targeting by Staphylococcal Leucotoxins: Retrograde Transport of Panton–Valentine Leucocidin and γ-Hemolysin

Toxins, 2017
Various membrane receptors associated with the innate immune response have recently been identified as mediators of the cellular action of Staphylococcus aureus leucotoxins.
Gaëlle Zimmermann-Meisse, Gilles Prévost, Emmanuel Jover   +2 more
doaj   +1 more source

C3, C5a and anti-acetylcholine receptor antibody as severity biomarkers in myasthenia gravis

Therapeutic Advances in Neurological Disorders, 2020
Background: Although the pathogenesis of myasthenia gravis (MG) is well known, prognostic markers are not yet available. We assessed the utility of anti-acetylcholine receptor (AChR) antibody (AChR-ab) titer and concentration of C3, C4, and C5a as ...
Florencia Aguirre, Analisa Manin, Victoria C. Fernandez, Mariano E. Justo, Juliana Leoni, Mariela L. Paz, Andres M. Villa   +6 more
doaj   +1 more source