Results 41 to 50 of about 17,322 (203)
Frontiers in Cellular Neuroscience, 2023 BackgroundThe extent of cortical pathology is an important determinant of multiple sclerosis (MS) severity. Cortical demyelination and neurodegeneration are related to inflammation of the overlying leptomeninges, a more inflammatory CSF milieu and with ...
Rhian Evans +11 more
doaj +1 more source
Chimeric Receptors of the Human C3a Receptor and C5a Receptor (CD88) [PDF]
Journal of Biological Chemistry, 1999 Chimeras were generated between the human anaphylatoxin C3a and C5a receptors (C3aR and C5aR, respectively) to define the structural requirements for ligand binding and discrimination. Chimeric receptors were generated by systematically exchanging between the two receptors four receptor modules (the N terminus, transmembrane regions 1 to 4, the second ...
T, Crass +7 more
openaire +2 more sources
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
Toxins, 2017 Various membrane receptors associated with the innate immune response have recently been identified as mediators of the cellular action of Staphylococcus aureus leucotoxins.
Gaëlle Zimmermann-Meisse +2 more
doaj +1 more source
p38MAPK, ERK and PI3K signaling pathways are involved in C5a-primed neutrophils for ANCA-mediated activation. [PDF]
PLoS ONE, 2012 BACKGROUND: The complement system is one of the important contributing factors in the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
Jian Hao +4 more
doaj +1 more source
Effects of a new C5a receptor antagonist on C5a‐ and endotoxin‐ induced neutropenia in the rat [PDF]
British Journal of Pharmacology, 1999 A new C5a receptor antagonist, the cyclic peptide Phe‐[Orn‐Pro‐D‐cyclohexylalanine‐Trp‐Arg], (F‐[OPdChaWR]), was tested for its ability to antagonize the neutropenic effects of both C5a and endotoxin in rats. Human recombinant C5a (2 μg kg−1 i.v.) caused rapid neutropenia, characterized by an 83% decrease in circulating polymorphonuclear leukocytes ...
Short, Anna +6 more
openaire +5 more sources
Advanced Science, EarlyView.A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li +13 more
wiley +1 more source
C3, C5a and anti-acetylcholine receptor antibody as severity biomarkers in myasthenia gravis
Therapeutic Advances in Neurological Disorders, 2020 Background: Although the pathogenesis of myasthenia gravis (MG) is well known, prognostic markers are not yet available. We assessed the utility of anti-acetylcholine receptor (AChR) antibody (AChR-ab) titer and concentration of C3, C4, and C5a as ...
Florencia Aguirre +6 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.This study demonstrated elevated levels of fecal component 3 (C3) and fibronectin (FN) in an ulcerative colitis (UC) mouse model. Importantly, fecal C3 exhibited a stronger correlation with disease activity than the clinically used fecal calprotectin (FC).
Yangyun Guo +6 more
wiley +1 more source
A dual receptor crosstalk model of G-protein-coupled signal transduction. [PDF]
PLoS Computational Biology, 2008 Macrophage cells that are stimulated by two different ligands that bind to G-protein-coupled receptors (GPCRs) usually respond as if the stimulus effects are additive, but for a minority of ligand combinations the response is synergistic.
Patrick Flaherty +6 more
doaj +1 more source