Effects of a new C5a receptor antagonist on C5a‐ and endotoxin‐ induced neutropenia in the rat [PDF]
British Journal of Pharmacology, 1999 A new C5a receptor antagonist, the cyclic peptide Phe‐[Orn‐Pro‐D‐cyclohexylalanine‐Trp‐Arg], (F‐[OPdChaWR]), was tested for its ability to antagonize the neutropenic effects of both C5a and endotoxin in rats. Human recombinant C5a (2 μg kg−1 i.v.) caused rapid neutropenia, characterized by an 83% decrease in circulating polymorphonuclear leukocytes ...
Short, Anna +6 more
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Cloning of the Human C5a Anaphylatoxin Receptor, and More [PDF]
Frontiers in Immunology, 2015 The initial observation in 1973 that the complement C5 activation product, C5a, has the ability to stimulate human neutrophils led to the concept of a specific C5a receptor (1). In the mid-1986, a groundbreaking paper published in Nature announced the cloning of the beta-adrenergic receptor, and for the first time established seven transmembrane (7TM ...
Gerard, Norma, Gerard, Craig John
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New developments in C5a receptor signaling
Cell Health and Cytoskeleton, 2012 Complement activation usually results in the formation of complement fragment 5a (C5a) that interacts with its two receptors, C5aR and C5L2. These receptors belong to the rhodopsin family of G protein-coupled seven transmembrane-containing receptors. C5aR and C5L2 are expressed on/in a wide variety of cells and tissues.
J Vidya, Sarma, Peter A, Ward
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Expression of C5a receptor in osteoblasts
The FASEB Journal, 2008 Anaphylatoxin C5a signaling plays an important role in inflammation‐associated bone diseases such as rheumatoid arthritis. However, expression and function of C5a receptor (C5aR) in the osteoblasts are largely unknown. The objective of this study is to determine C5aR expression and its function in the osteoblasts.
Tao Jiang, Hongwei Gao
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Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody. [PDF]
J Innate Immun, 2023 Cyranka L +6 more
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New aspects of the C5a receptor
Advances in Bioscience and Biotechnology, 2014 The process of apoptotic cell death for maintenance of cell homeostasis is now believed to be flexible. To examine the mechanism for this flexibility, the process of programmed cell death is sometimes divided into three phases: initiation, effector and execution.
Hiroshi Nishiura, Kiyoshi Ohura
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Increased Expression of Anaphylatoxin C5a-Receptor-1 in Neutrophils and Natural Killer Cells of Preterm Infants. [PDF]
Int J Mol Sci, 2023 Boeckel H +6 more
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Anaphylatoxin C5a receptor signaling induces mitochondrial fusion and sensitizes retinal pigment epithelial cells to oxidative stress. [PDF]
Biochim Biophys Acta Gen Subj, 2023 Ishii M, Rohrer B.
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Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages. [PDF]
J Innate Immun, 2023 Wu KC +5 more
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C5a receptor inhibitor avacopan in immunoglobulin A nephropathy-an open-label pilot study. [PDF]
Clin Kidney J, 2022 Bruchfeld A +7 more
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