Results 101 to 110 of about 6,618 (201)
Frontiers in Cellular and Infection Microbiology, 2019 Respiratory viral infections can directly lead to kidney damage such as IgA nephropathy (IgAN), partly due to mucosal immune system dysfunction. Although the activated C5a-C5aR1 axis results in increased Th1 and Th17 frequencies but reduced Treg ...
Xinyue Hu +8 more
doaj +1 more source
Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients
Frontiers in Immunology, 2020 Initially underestimated as platelet dust, extracellular vesicles are continuously gaining interest in the field of inflammation. Various studies addressing inflammatory diseases have shown that microvesicles (MVs) originating from different cell types ...
Ebru Karasu +10 more
doaj +1 more source
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen +5 more
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Eng Soo Yap +2 more
wiley +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn +5 more
wiley +1 more source
C5aR1 governs Mreg migration, development, and function [PDF]
American Journal of Transplantation, 2019 Paloma, Riquelme +2 more
openaire +2 more sources
EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential
, 2020 Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects
Cauchy, P. +6 more
core +1 more source
C5aR1+ macrophages are involved in the progression of endometriosis
Reproductive and Developmental MedicineObjective: Immune dysfunction plays an important role in the pathogenesis of endometriosis. C5a, a by-product of complement activation, binds to its receptor (C5a receptor 1, C5aR1) in various cells, including macrophages. The combination of C5a and C5aR1 in macrophages induces M2 polarization. There is no consistent conclusion
Xi Chen +3 more
openaire +1 more source
C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta
ASN Neuro, 2017 C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 antagonist, PMX205, decreased amyloid pathology and suppressed cognitive ...
Michael X. Hernandez +4 more
doaj +1 more source
RNA sequencing screening of differentially expressed genes after spinal cord injury
Neural Regeneration Research, 2019 In the search for a therapeutic schedule for spinal cord injury, it is necessary to understand key genes and their corresponding regulatory networks involved in the spinal cord injury process.
Yi Li +7 more
doaj +1 more source