Results 101 to 110 of about 5,552 (193)

Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs

bioRxiv
Administration of selective serotonin reuptake inhibitors (SSRIs) is associated with a reduced cancer risk and shows significant anti-tumor effects across multiple tumor types, suggesting the potential for repurposing SSRIs in cancer therapy. Nonetheless,
Fangyuan Dong, Shan Zhang, Kaiyuan Song, Luju Jiang, Lipeng Hu, Qing Li, Xue-Li Zhang, Jun Li, Ming-Xuan Feng, Zhi-Wei Cai, Hong-Fei Yao, Rong-Kun Li, Hui Li, Jie Chen, Xiao-Na Hu, Jiao-Feng Wang, C. Jiang, H. Zhu, Cun Wang, Lin-Tai Da, Zhignang Zhang, Zhi-Jun Bao, Xu Wang, Shu-Heng Jiang   +23 more
semanticscholar   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Yuye Jinhua Qingre Tablets Attenuate Acute Pharyngitis by inhibiting the Complement Cascade and C5a/C5aR1 Axis

Chinese Medicine
Acute pharyngitis (AP) is a common upper respiratory tract infection, primarily characterized by symptoms such as throat pain, redness, swelling, and difficulty swallowing. It is typically caused by viral infections, bacterial infections, or physical and
Yifei Gao, Leiming You, Ji-Ying Zhou, Xiaoyu Tao, Zhengseng Jin, Chao-yong Wu, Fanqin Zhang, Siyu Guo, Haojia Wang, Yueqin Guan, Hua Luo, Jia-Rui Wu   +11 more
semanticscholar   +1 more source

Respiratory Syncytial Virus Exacerbates Kidney Damages in IgA Nephropathy Mice via the C5a-C5aR1 Axis Orchestrating Th17 Cell Responses

Frontiers in Cellular and Infection Microbiology, 2019
Respiratory viral infections can directly lead to kidney damage such as IgA nephropathy (IgAN), partly due to mucosal immune system dysfunction. Although the activated C5a-C5aR1 axis results in increased Th1 and Th17 frequencies but reduced Treg ...
Xinyue Hu, Juntao Feng, Qiaoling Zhou, Lisha Luo, Ting Meng, Yong Zhong, Wei Tang, Shuanglinzi Deng, Xiaozhao Li   +8 more
doaj   +1 more source

AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis

Frontiers in Pharmacology
Background Gout, a prevalent and severe form of arthritis precipitated by hyperuricemia, has been the subject of extensive research. However, the intricate underlying mechanisms governing gout-related inflammation are still only partially elucidated ...
Sijing Liu, Yongli Situ, Li Deng, Meng Liang, Haoyuan He, Zheng-Fu Shao, Lifei Peng   +6 more
semanticscholar   +1 more source

Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

Molecular Neurodegeneration, 2017
Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's disease (AD) mouse models.
Michael X. Hernandez, Shan Jiang, Tracy A. Cole, Shu-Hui Chu, Maria I. Fonseca, Melody J. Fang, Lindsay A. Hohsfield, Maria D. Torres, Kim N. Green, Rick A. Wetsel, Ali Mortazavi, Andrea J. Tenner   +11 more
doaj   +1 more source

C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta

ASN Neuro, 2017
C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 antagonist, PMX205, decreased amyloid pathology and suppressed cognitive ...
Michael X. Hernandez, Pouya Namiranian, Eric Nguyen, Maria I. Fonseca, Andrea J. Tenner   +4 more
doaj   +1 more source

C5aR1 governs Mreg migration, development, and function [PDF]

American Journal of Transplantation, 2019
Paloma, Riquelme, Edward K, Geissler, James A, Hutchinson   +2 more
openaire   +2 more sources

Single-cell transcriptomics and machine learning reveal RNF144B and C5AR1 as immune-related biomarkers and therapeutic targets in myocardial infarction

bioRxiv
Background Myocardial infarction (MI) is a life-threatening cardiovascular disease characterized by high morbidity and mortality. Although advances in clinical management have improved patient outcomes, early diagnosis and effective immunomodulatory ...
Yu-Xin Hu, Lu Chen, Jianmei Sha, Caihong Shao, Junli Gao, Jianhua Yao   +5 more
semanticscholar   +1 more source

C5aR1-positive adipocytes mediate non-shivering thermogenesis in neonatal mice

iScience
Brown adipose tissue (BAT) plays an important role in maintaining body temperature in newborn mammals; however, its mechanisms remain poorly understood. Here, we report the identification of a special population of brown adipose tissue-derived stromal cells (ASCs) in neonatal mice that highly express CD45 and can be differentiated into adipocytes with ...
Huan-Yu Wang, Xue-Min Peng, Min Yang, Ying Weng, Xi Yang, Di Zhan, Qin Ning, Xiao-Ping Luo, Yong Chen   +8 more
openaire   +3 more sources