Results 31 to 40 of about 5,552 (193)

C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment

Ecotoxicology and Environmental Safety
A mounting number of studies have been documenting strong pro-inflammatory and pro-fibrotic effects of carbon nanotube (CNT). However, the molecular mechanisms of single-walled CNT (SWCNT)-provoked lung injury remain to be elucidated.
Jiaojiao Zhu, Xiang Zhang, Lanlan Li, Hongxu Yang, Hang Liu, Danyang Wu, Zikai Liu, Bin Liu, Tong Shen   +8 more
doaj   +2 more sources

C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model

Nature Communications
Alzheimer’s disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. The complement pathway has been proposed as a therapeutic target.
Nicole D. Schartz, Heidi Y. Liang, Klebea Carvalho, Shu-Hui Chu, Adrian Mendoza-Arvilla, Tiffany J. Petrisko, Angela Gomez-Arboledas, Ali Mortazavi, Andrea J. Tenner   +8 more
doaj   +2 more sources

Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia

npj Aging
Vascular dementia (VaD) is the second most common cause of dementia. Few bioinformatic analysis has been done to explore its biomarkers. This study aimed to excavate potential biomarkers for VaD using bioinformatic analysis and validate them at both ...
Yawen Xu, Hailing Zhang, Xuehao Jiao, Yanbo Zhang, Ge Yin, Cui Wang, Zengkan Du, Meng Liang, Xin Gao, Zhengsheng Gu, Yan Jiang, Bing-Ying Du, Xiaoying Bi   +12 more
semanticscholar   +3 more sources

UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment

Cell Death and Disease
Dysregulation of the C5a-C5a receptor 1 (C5aR1) signalling axis underlies inflammation and immune-driven pathology. C5aR1 was traditionally thought to be primarily expressed on the cell membrane, although recent reports indicate the importance of ...
Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai, Heather O. L. Clark, David J. MacLean, Nicole Machado, Gonzalo Rodriguez-Berriguete, Lolita Singh, Geoff S. Higgins, Ester M. Hammond, Monica M. Olcina   +10 more
doaj   +2 more sources

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

The Journal of Clinical Investigation, 2023
An immunosuppressive microenvironment causes poor tumor T cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumors is still a challenge.
Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K. Nambiar, Ryan K. Kim, Gabriel N. Valbuena, Silvia Guglietta, Carsten Krieg, Mahnaz Darvish-Damavandi, Tatsuya Suwa, Alistair Easton, Lily V.S. Hillson, Ashley K. McCulloch, Ross K. McMahon, Kathryn Pennel, Joanne Edwards, Sean M. O’Cathail, Campbell S. Roxburgh, Enric Domingo, Eui Jung Moon, Dadi Jiang, Yanyan Jiang, Qingyang Zhang, Albert C. Koong, Trent M. Woodruff, Edward E. Graves, Tim Maughan, Simon J.A. Buczacki, Manuel Stucki, Quynh-Thu Le, Simon J. Leedham, Amato J. Giaccia, Monica M. Olcina   +33 more
doaj   +9 more sources

Role of C5aR1 and C5L2 Receptors in Ischemia-Reperfusion Injury [PDF]

Journal of Clinical Medicine, 2021
The role of C5a receptors (C5aR1 and C5L2) in renal ischemia-reperfusion injury (IRI) is uncertain. We generated an in vitro model of hypoxia/reoxygenation with human proximal tubule epithelial cells to mimic some IRI events. C5aR1, membrane attack complex (MAC) and factor H (FH) deposits were evaluated with immunofluorescence.
Carlos Arias-Cabrales, Eva Rodriguez-Garcia, Javier Gimeno, David Benito, María José Pérez-Sáez, Dolores Redondo-Pachón, Anna Buxeda, Carla Burballa, Marta Crespo, Marta Riera, Julio Pascual   +10 more
openaire   +2 more sources

C5a/C5aR1 mediates the IMQ-induced psoriatic skin inflammation via promoting IL-17A expression by γδ T cells in mice [PDF]

Jichu yixue yu linchuang, 2022
Objective To explore the effects and underlying mechanism of C5a/C5aR1 pathway in mediating imiquimod (IMQ)-induced psoriatic skin inflammation by increasing IL-17A expression in γδ T cells.
ZHENG Quan-you, LIANG Shen-ju,SHU Yong, ZHOU Shan, ZHONG Yu, SHENG Fen, TANG Ming-jun
doaj   +1 more source

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

Journal of Innate Immunity, 2023
Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka, Ida Mariegaard, Mikkel-Ole Skjødt, Rafael Bayarri-Olmos, Tom Eirik Mollnes, Peter Garred, Anne Rosbjerg   +6 more
doaj   +1 more source

The C5a/C5aR1 axis controls the development of experimental allergic asthma independent of LysM-expressing pulmonary immune cells. [PDF]

PLoS ONE, 2017
C5a regulates the development of maladaptive immune responses in allergic asthma mainly through the activation of C5a receptor 1 (C5aR1). Yet, the cell types and the mechanisms underlying this regulation are ill-defined.
Anna V Wiese, Fanny Ender, Katharina M Quell, Konstantina Antoniou, Tillman Vollbrandt, Peter König, Jörg Köhl, Yves Laumonnier   +7 more
doaj   +1 more source

The activation of complement C5a-C5aR1 axis in astrocytes facilitates the neuropathogenesis due to EV-A71 infection by upregulating CXCL1

Journal of Virology
Enterovirus A71 (EV-A71) is a common small RNA virus that is highly neuroinvasive. Emerging evidence indicates that the complement fragment C5a and its receptor C5aR1 are important drivers of neuroinflammation.
Peiyu Zhu, Wangquan Ji, Dong Li, Fang Wang, Tiantian Sun, Haiyan Yang, Shuaiyin Chen, Weiguo Zhang, Yuefei Jin, Guangcai Duan   +9 more
doaj   +2 more sources