Results 31 to 40 of about 4,383 (167)

Helix 8 in chemotactic receptors of the complement system.

PLoS Computational Biology, 2022
Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski, Paulina Dragan, Anna Makal, Dorota Latek   +3 more
doaj   +1 more source

C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli [PDF]

JCI Insight, 2017
C5a receptor 1 (C5aR1) is a G protein–coupled receptor for C5a and also an N-linked glycosylated protein. In addition to myeloid cells, C5aR1 is expressed on epithelial cells. In this study, we examined the role of C5aR1 in bacterial adhesion/colonization of renal tubular epithelium and addressed the underlying mechanisms of this ...
Li K, Wu KY, Wu W, Wang N, Zhang T, Choudhry N, Song Y, Farrar CA, Ma L, Wei LL, Duan ZY, Dong X, Liu EQ, Li ZF, Sacks SH, Zhou W   +15 more
openaire   +3 more sources

FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins

Life Science Alliance, 2023
FBXO11 regulates the expression of the complement receptor C5aR1 and the inflammatory cytokine IL-1β, affecting how macrophages respond to Staphylococcus aureus pore–forming toxins.
Yusun Jeon, Seong H Chow, Isabella Stuart, Ashley Weir, Amy TY Yeung, Christine Hale, Sushmita Sridhar, Gordon Dougan, James E Vince, Thomas Naderer   +9 more
doaj   +1 more source

C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation

Theranostics, 2020
Numerous factors have been claimed to play important roles in colorectal cancer (CRC) tumorigenesis, including myeloid-derived suppressor cells (MDSCs) and other immune cells, cytokines, and chemokines; however, the precise mechanisms of colorectal tumorigenesis remain elusive, and there is a lack of effective preventive treatments.
Ding, Peipei, Li, Ling, Li, Luying, Lv, Xinyue, Zhou, Danlei, Wang, Qingkai, Chen, Jianfeng, Yang, Chaoqun, Xu, Enjie, Dai, Weixing, Zhang, Xin, Wang, Na, Wang, Qi, Zhang, Wei, Zhang, Long, Zhou, Yuzhen, Gu, Hongyu, Lei, Qunying, Zhou, Xuhui, Hu, Weiguo   +19 more
openaire   +2 more sources

Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection

Pathogens, 2015
The complement anaphylatoxin C5a contributes to host defense against Staphylococcus aureus. In this study, we investigated the functional role of the two known C5a receptors, C5aR1 and C5aR2, in the host response to S. aureus. We found that C5aR1−/− mice
Sarah A. Horst, Andreas Itzek, Andreas Klos, Andreas Beineke, Eva Medina   +4 more
doaj   +1 more source

Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure

Biological Psychiatry Global Open Science
Background: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive.
Hsiao-Jou Cortina Chen, Jereme G. Spiers, Titaya Lerskiatiphanich, Sandra E. Parker, Nickolas A. Lavidis, Jenny N. Fung, Trent M. Woodruff, John D. Lee   +7 more
doaj   +1 more source

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Skeletal Muscle, 2017
Background The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune ...
Haitao A. Wang, John D. Lee, Kah Meng Lee, Trent M. Woodruff, Peter G. Noakes   +4 more
doaj   +1 more source

TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection

Frontiers in Immunology, 2023
BackgroundAn essential fact underlying the severity of Staphylococcus aureus (S. aureus) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane receptors.
Jie He, Xianggui Yang, Kai Yang, Honglin Xu, Cheng Chen, Junxiong Wang, Jun Zeng   +6 more
doaj   +1 more source

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

Neurobiology of Disease, 2015
The role of complement system-mediated inflammation is of key interest in seizure and epilepsy pathophysiology, but its therapeutic potential has not yet been explored.
Melissa J. Benson, Nicola K. Thomas, Sahil Talwar, Mark P. Hodson, Joseph W. Lynch, Trent M. Woodruff, Karin Borges   +6 more
doaj   +1 more source

Abstract 2950: Humanized C5AR1 mouse model (B-hC5AR1 mice) for evaluation of anti-C5AR1 mAb in vivo efficacy

Cancer Research, 2021
Abstract C5AR1 (complement C5a receptor 1) is a classical G protein-coupled receptor that is mainly expressed on granulocytes, monocytes, dendritic cells and MDSCs (Myeloid-derived suppressor cells) in several cancer types. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature cells that play a significant role ...
Yanhui Nie, Xiaofei Zhou, Jing Zhang, Veronika Chromikova, Yuelei Shen   +4 more
openaire   +1 more source