Results 11 to 20 of about 5,552 (193)

C5aR1 and cGAS/STING and their possible involvement in radiosensitivity of colorectal cancer [PDF]

iScience
Summary: Worldwide, colorectal cancer (CRC) stands as the third leading cancer in terms of both diagnosis and mortality, underscoring its significant global health impact.
Quoc Thao Trang Pham, Pei-Ju Lee, Nguyen Quoc Khanh Le   +2 more
doaj   +4 more sources

C5aR1 Inhibition Alleviates Cranial Radiation-Induced Cognitive Decline. [PDF]

Cancer Res
Cranial radiation therapy (RT) for brain cancers leads to an irreversible decline in cognitive function without an available remedy. Radiation-induced cognitive decline (RICD) is a particularly pressing problem for brain cancer survivors who live long ...
Krattli RP, Do AH, El-Khatib SM, Alikhani L, Markarian M, Vagadia AR, Usmani MT, Madan S, Baulch JE, Clark RJ, Woodruff TM, Tenner AJ, Acharya MM.   +12 more
europepmc   +9 more sources

Evaluating the usefulness of C5 and C5AR1 as genetic biomarkers of IgA-mediated vasculitis

Molecular Medicine
Background IgA-mediated vasculitis (IgAV) is a complex inflammatory disease. Unravelling its genetic background would allow us to identify genetic biomarkers that may be used as additional tools in its daily management, helping to solve the clinical ...
Joao Carlos Batista-Liz, Vanesa Calvo-Río, María Sebastián Mora-Gil, María Teresa Leonardo, Ana Cristina Peñalba, Luis Martín-Penagos, Javier Narváez, Belén Sevilla-Pérez, José Luis Callejas-Rubio, Ligia Gabrie, Rafael Gálvez Sánchez, Luis Caminal-Montero, Paz Collado, María José Rodríguez Valls, Diego de Argila, Patricia Quiroga-Colina, Esther Francisca Vicente-Rabaneda, Esteban Rubio, Manuel León Luque, Juan María Blanco-Madrigal, Eva Galíndez-Agirregoikoa, Ricardo Blanco, Verónica Pulito-Cueto, Raquel López-Mejías   +23 more
doaj   +5 more sources

Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis [PDF]

Nature, 2020
Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1.
Julien Carvelli, O. Demaria, F. Vely, L. Batista, Nassima Chouaki Benmansour, J. Fares, S. Carpentier, Marie-Laure Thibult, Ariane Morel, R. Remark, P. André, Agnès Représa, C. Pipéroglou, Laura Assante Miranda, William Baron, Nourhène Belaid, C. Caillet, Flavien Caraguel, Barbara Carrette, Florent Carrette, Fabien Chanuc, Rachel Courtois, Aurore Fenis, Marilyn Giordano, Mathilde Girard-Madoux, Marc Giraudon-Paoli, Nicolas Gourdin, Gwendoline Grondin, Franceline Guillot, Guillaume Habif, Solène Jaubert, Julie Lopez, Mélanie Le Van, Naouel Lovera, Marine Mansuy, E. Bonnet, Audrey Sansaloni, Anne Reboul, Emmanuel Mitry, Camille Nekkar-Constant, Valentine Péri, Paul Ricaut, Léa Simon, Jean-Baptiste Vallier, Marie Vétizou, R. Zerbib, Sophie Ugolini, Marion Etiennot, Justine Galluso, Luc Lyonnet, J. Forel, L. Papazian, Lionel Velly, B. André, Antoine Briantais, Benoit Faucher, Estelle Jean, Julie Seguier, V. Veit, J. Harlé, B. Pastorino, Clémence Delteil, L. Daniel, Jean-Paul Boudsocq, Axelle Clerc, Emmanuel Delmond, Pierre-Olivier Vidal, Hélène Savini, Bruno Coutard, P. Cordier, E. le Dault, C. Guervilly, P. Simeone, M. Gainnier, Y. Morel, M. Ebbo, N. Schleinitz, É. Vivier   +77 more
semanticscholar   +10 more sources

Mechanism of activation and biased signaling in complement receptor C5aR1

Cell Research, 2023
The complement system plays an important role in the innate immune response to invading pathogens. The complement fragment C5a is one of its important effector components and exerts diverse physiological functions through activation of the C5a receptor 1
Yu-Ying Feng, Chang Zhao, Yue Deng, Heli Wang, Liang Ma, Si-Yue Liu, Xiaowen Tian, Bo Wang, Yan Bin, Peipei Chen, Wei Yan, P. Fu, Zhenhua Shao   +12 more
semanticscholar   +3 more sources

Novel interactions between the C5‐C5aR1 Axis and IF1: Implications for kidney mitochondrial physiology and ischemia–reperfusion injury [PDF]

Physiological Reports
Ischemia‐reperfusion injury (IRI) is a prevalent condition that predominantly afflicts hospitalized patients, inducing acute kidney injury (AKI). In recent years, complement 5 (C5) and its anaphylatoxin receptor C5aR1 have been implicated in driving ...
Madison McGraw, Amod Sharma, Dinesh Bhattarai, Neriman Gokden, LeeAnn Macmillan‐Crow, Nirmala Parajuli   +5 more
doaj   +2 more sources

Complement C5a/C5aR1 pathway facilitates glioblastoma progression via fostering glioma stem cell-macrophage symbiosis [PDF]

Journal of Neuroinflammation
Tumor-associated macrophages (TAMs) symbiotically interact with glioma stem cells (GSCs) to facilitate GSCs stemness maintenance and glioblastoma (GBM) progression.
Hongtao Zhu, Lidong Cheng, Dan Liu, Yixuan Ma, Heng Fan, Shuting He, Wenjia Liang, Daluo Mei, Xiaoyu Ma, Ran Li, Hailong Mi, Junwen Wang, Jun Li, Xingjiang Yu, Suojun Zhang, Kai Shu   +15 more
doaj   +2 more sources

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. [PDF]

PLoS ONE, 2017
The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts.
Stephanie Bergdolt, Anna Kovtun, Yvonne Hägele, Astrid Liedert, Thorsten Schinke, Michael Amling, Markus Huber-Lang, Anita Ignatius   +7 more
doaj   +4 more sources

Integrative Transcriptomic Analysis and Functional Validation Implicate GPT2 in Glycolytic Regulation in Polycystic Ovary Syndrome. [PDF]

Food Sci Nutr
Integrating GEO transcriptomic datasets, machine‐learning algorithms, GSVA, multilayer regulatory network and immune infiltration analyses, this study revealed metabolic‐immune disturbance and aberrant ovarian steroidogenesis in polycystic ovary syndrome (PCOS).
Xi M, Luo R, Zhang J, Huang W, Ma L, Sun Y, Ren A.   +6 more
europepmc   +2 more sources

Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression [PDF]

Journal of Neuroinflammation, 2022
Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of ...
Klebea Carvalho, Nicole D. Schartz, Gabriela Balderrama-Gutierrez, Heidi Y. Liang, Shu-Hui Chu, Purnika Selvan, Angela Gomez-Arboledas, Tiffany J. Petrisko, Maria I. Fonseca, Ali Mortazavi, Andrea J. Tenner   +10 more
doaj   +4 more sources