Results 11 to 20 of about 4,383 (167)

Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression [PDF]

Journal of Neuroinflammation, 2022
Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of ...
Klebea Carvalho, Nicole D. Schartz, Gabriela Balderrama-Gutierrez, Heidi Y. Liang, Shu-Hui Chu, Purnika Selvan, Angela Gomez-Arboledas, Tiffany J. Petrisko, Maria I. Fonseca, Ali Mortazavi, Andrea J. Tenner   +10 more
doaj   +4 more sources

C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis [PDF]

Frontiers in Immunology, 2019
Psoriasis is one of the most common chronic inflammatory skin diseases, affecting ~2% of the population. The lack of characterization of the pathogenesis of psoriasis has hindered efficient clinical treatment of the disease.
Quan-you Zheng, Quan-you Zheng, Shen-ju Liang, Feng Xu, Gui-qing Li, Na Luo, Shun Wu, You Li, Ming Tang, Yu Zhong, Jian Chen, Di Yang, Dao-dong Sun, Ke-qin Zhang, Gui-lian Xu   +14 more
doaj   +3 more sources

C5a–C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms

Scientific Reports
Recent studies have indicated the involvement of neutrophil-mediated inflammatory responses in the process leading to intracranial aneurysm (IA) rupture. Receptors mediating neutrophil recruitment could thus be therapeutic targets of unruptured IAs.
Akihiro Okada, Kampei Shimizu, Akitsugu Kawashima, Tomomichi Kayahara, Masahiko Itani, Hiroki Kurita, Susumu Miyamoto, Hiroharu Kataoka, Tomohiro Aoki   +8 more
doaj   +3 more sources

C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages

Journal of Immunology Research
As another receptor for complement activation product C5a, C5aR2 has been paid much attention these years. Although controversial and complex, its specific signals or roles in modulating the classic receptor C5aR1 have been investigated and gradually ...
Ting Zhang, Ning Ma, Jiaxing Wang, Xiaoyun Min, Linlin Wei, Ke Li   +5 more
doaj   +3 more sources

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

The Journal of Clinical Investigation, 2023
An immunosuppressive microenvironment causes poor tumor T cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumors is still a challenge.
Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K. Nambiar, Ryan K. Kim, Gabriel N. Valbuena, Silvia Guglietta, Carsten Krieg, Mahnaz Darvish-Damavandi, Tatsuya Suwa, Alistair Easton, Lily V.S. Hillson, Ashley K. McCulloch, Ross K. McMahon, Kathryn Pennel, Joanne Edwards, Sean M. O’Cathail, Campbell S. Roxburgh, Enric Domingo, Eui Jung Moon, Dadi Jiang, Yanyan Jiang, Qingyang Zhang, Albert C. Koong, Trent M. Woodruff, Edward E. Graves, Tim Maughan, Simon J.A. Buczacki, Manuel Stucki, Quynh-Thu Le, Simon J. Leedham, Amato J. Giaccia, Monica M. Olcina   +33 more
doaj   +9 more sources

Role of C5aR1 and C5L2 Receptors in Ischemia-Reperfusion Injury [PDF]

Journal of Clinical Medicine, 2021
The role of C5a receptors (C5aR1 and C5L2) in renal ischemia-reperfusion injury (IRI) is uncertain. We generated an in vitro model of hypoxia/reoxygenation with human proximal tubule epithelial cells to mimic some IRI events. C5aR1, membrane attack complex (MAC) and factor H (FH) deposits were evaluated with immunofluorescence.
Carlos Arias-Cabrales, Eva Rodriguez-Garcia, Javier Gimeno, David Benito, María José Pérez-Sáez, Dolores Redondo-Pachón, Anna Buxeda, Carla Burballa, Marta Crespo, Marta Riera, Julio Pascual   +10 more
openaire   +2 more sources

The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics [PDF]

Trends in Immunology, 2020
The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy ...
Woodruff, Trent M., Shukla, Arun K.
openaire   +9 more sources

C5aR1 Inhibition Alleviates Cranial Radiation-Induced Cognitive Decline. [PDF]

Cancer Res
ABSTRACT Cranial radiation therapy (RT) for brain cancers leads to an irreversible decline in cognitive function without an available remedy. Radiation-induced cognitive deficits (RICD) are a particularly pressing problem for the survivors of pediatric and low grade glioma (LGG) cancers who often live long post-RT ...
Krattli RP, Do AH, El-Khatib SM, Alikhani L, Markarian M, Vagadia AR, Usmani MT, Madan S, Baulch JE, Clark RJ, Woodruff TM, Tenner AJ, Acharya MM.   +12 more
europepmc   +7 more sources

Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse [PDF]

The Journal of Immunology, 2015
Abstract Many of the biological properties of C5a are mediated through activation of its receptor (C5aR1), the expression of which has been demonstrated convincingly on myeloid cells, such as neutrophils, monocytes, and macrophages. In contrast, conflicting results exist regarding C5aR1 expression in dendritic cells (DCs) and lymphoid ...
Christian M, Karsten, Yves, Laumonnier, Benjamin, Eurich, Fanny, Ender, Katharina, Bröker, Sreeja, Roy, Anna, Czabanska, Tillman, Vollbrandt, Julia, Figge, Jörg, Köhl   +9 more
openaire   +2 more sources

Mechanism of activation and biased signaling in complement receptor C5aR1

Cell Research, 2023
AbstractThe complement system plays an important role in the innate immune response to invading pathogens. The complement fragment C5a is one of its important effector components and exerts diverse physiological functions through activation of the C5a receptor 1 (C5aR1) and associated downstream G protein and β-arrestin signaling pathways.
Yuying Feng, Chang Zhao, Yue Deng, Heli Wang, Liang Ma, Sicen Liu, Xiaowen Tian, Bo Wang, Yan Bin, Peipei Chen, Wei Yan, Ping Fu, Zhenhua Shao   +12 more
openaire   +2 more sources