Results 91 to 100 of about 1,239,345 (193)

Inhibiting the C5-C5a receptor axis

, 2011
Activation of the complement system is a major pathogenic event that drives various inflammatory responses in numerous diseases. All pathways of complement activation lead to cleavage of the C5 molecule generating the anaphylatoxin C5a and, C5b that ...
Francesco Tedesco, Kutty S. Nandakumar, Woodruff, Trent M., Nandakumar, Kutty S., Trent M. Woodruff, Tedesco, Francesco   +5 more
core   +1 more source

Potential Targets and Signaling Mechanisms of Cinnamaldehyde Enhancing Intestinal Function and Nutritional Regulation in Fat Greenling (Hexagrammos otakii)

Aquaculture Nutrition
Cinnamaldehyde is an ideal feed additive with good immune enhancement and anti-inflammatory regulation effects. However, the anti-inflammatory regulation mechanism in fat greenling (Hexagrammos otakii, H. otakii) remains unclear.
Yixin Gu, Yu Zhan, Yafeng Guo, Wenyuan Hua, Xin Qi, Zhizhi Gu, Shengnan Cao, Yan Chen, Zhuang Xue, Wei Wang   +9 more
doaj   +1 more source

Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo: Mediation by interleukin-6 from Kupffer cells

, 2002
Background & Aims: In normal rat liver, anaphylatoxin C5a induces glucose output from hepatocytes indirectly via prostanoids released from Kupffer cells.
Jungermann, K., Kurt Jungermann, Henrike L. Schieferdecker, Milena Koleva, Koleva, M., Gotze, O., Schieferdecker, H. L., Regine Landmann, Landmann, R., Otto Götze, Schlaf, G., Gerald Schlaf   +11 more
core   +1 more source

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation

Respiratory Research
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) pandemic has challenged the current understanding of the complement cascade mechanisms of host immune responses during infection-induced ...
Pooja Shivshankar, Stacey L. Mueller-Ortiz, Aleksey Y. Domozhirov, Weizhen Bi, Scott D. Collum, Marie-Francoise Doursout, Manish Patel, Isabella N. LeFebvre, Bindu Akkanti, Simon Yau, Howard J. Huang, Rahat Hussain, Harry Karmouty-Quintana   +12 more
doaj   +1 more source

Anaphylatoxin C5a Production During Short-Term Submaximal Dynamic Exercise in Man

, 1994
peer reviewedWe studied the effects of short-term submaximal exercise on the plasma levels of myeloperoxidase ([MPO]) and C5a anaphylatoxin ([C5a]), taken as specific markers of polymorphonuclear neutrophil (PMN) and complement activation, respectively ...
Juchmes-Ferir, A., Duchateau, J., Deby, Ginette, Lamy, Maurice, Pincemail, Joël, Camus, G., Deby, C., Feron, Frédéric   +7 more
core   +1 more source

Proteomics of left ventricular structure in the Multi‐Ethnic Study of Atherosclerosis

ESC Heart Failure
Aims Proteomic profiling offers an expansive approach to biomarker discovery and mechanistic hypothesis generation for LV remodelling, a critical component of heart failure (HF).
Tess E. Peterson, Joao A.C. Lima, Sanjiv J. Shah, David A. Bluemke, Alain G. Bertoni, Yongmei Liu, Debby Ngo, Vinithra Varadarajan, Josyf C. Mychaleckyj, Craig W. Johnson, Bruce M. Psaty, Clary B. Clish, Kent D. Taylor, Peter Durda, Russell P. Tracy, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Wendy S. Post, James S. Pankow   +19 more
doaj   +1 more source

IL-4 down-regulates anaphylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migration in vivo

, 2003
Anaphylatoxins mobilize leukocytes to the sites of inflammation. In the present study we investigated the impact of GM-CSF, IL-4, and IFN-gamma on anaphylatoxin receptor expression in monocytes and dendritic cells (DC).
Zwirner, Joerg, Riggert, Joachim, Dettmer, C., Soruri, Afsaneh, Kiafard, Z., Kohl, J.   +5 more
core   +1 more source

Anaphylatoxin C5a-mediated reduction in cytokine and chemokine production depends on Sphk1.

, 2012
BMDMs from Sphk1+/+ or Sphk1−/− mice were stimulated with LPS (500 ng/ml), with LPS concomitant with C5a (1 nM), or without C5a. Tissue culture supernatants were harvested 2 h (TNF-α) or 8 h (IL-6 and KC) after the addition of stimuli. (A) TNF-α; (B); IL-
Xiaopei Gao (183926), Kurt Bachmaier (183907), Edgar Guzman (183914), Takeshi Kawamura (183920), Asrar B. Malik (183932)   +4 more
core   +1 more source

Development of response-selective agonists of human C5a anaphylatoxin: Conformational, biological, and therapeutic considerations

, 2001
Numerous studies on the relationship between the structure and function of peptide agonists derived from the biologically active, C-terminal region of human C5a anaphylatoxin have been reported over the past decade. These studies have been performed with
Sanderson, Sam D., Sherman, Simon A., Kirnarsky, Leonid, Taylor, Stephen M.   +3 more
core   +1 more source

Cloning and functional expression of the canine anaphylatoxin C5a receptor. Evidence for high interspecies variability.

, 1992
A cDNA clone, DTJP03, encoding an orphan receptor, was isolated from a canine thyroid library, and found to exhibit 68.6% amino-acid identity with the recently described human C5a receptor.
Raspé, Eric, Parmentier, Marc, Perret, Jason, Vassart, Gilbert   +3 more
core