Results 91 to 100 of about 6,320 (210)

Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice [PDF]

, 2014
Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated with high morbidity and mortality. The complement system and TLRs provide important pattern recognition receptors initiating the cytokine storm by ...
Barratt-Due, Andreas, Denk, Stephanie, Espevik, Terje, Gaus, Wilhelm, Huber-Lang, Markus, Mollnes, Tom E., Nilsson, Per H., Nunn, Miles A., Pischke, Søren E., Sandanger, Øystein   +9 more
core   +1 more source

Complement and transplant‐associated thrombotic microangiopathy: Current and future approaches

HemaSphere, Volume 10, Issue 4, April 2026.
Massimo Cugno, Francesco Onida, Bernhard Lämmle   +2 more
wiley   +1 more source

JAK Inhibitors as a Novel Approach to Autoimmune Bullous Diseases: A Review

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Autoimmune bullous diseases (AIBDs) are a group of chronic disorders characterized by blister formation resulting from abnormal immune responses. Janus kinase (JAK) inhibitors have emerged as promising therapeutic agents for AIBDs. This review discusses the use of JAK inhibitors—such as upadacitinib, baricitinib, tofacitinib, and abrocitinib, among ...
Olga Olisova, Yuliya Kolesova, Natalia Teplyuk, Ekaterina Grekova, Leyi Ni, Alina Mardanova, Karim Karray, Anastasiia Tikhonova, Anfisa Lepekhova, Jaime Piquero-Casals   +9 more
wiley   +1 more source

Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Sbcutaneous Adipose Tissue and Adipocytes in Acquired Obesity [PDF]

, 2017
Inflammation is an important mediator of obesity-related complications such as the metabolic syndrome but its causes and mechanisms are unknown. As the complement system is a key mediator of inflammation, we studied whether it is activated in acquired ...
Hakkarainen, Antti, Hanttu, Anna, Heinonen, Sini, Kaprio, Jaakko, Kaye, Sanna, Lokki, A. Inkeri, Lundbom, Jesper, Lundbom, Nina, Meri, Seppo, Muniandy, Maheswary, Nissilä, Eija, Pietiläinen, Kirsi H., Rissanen, Aila, Saarinen, Lilli, Tynninen, Olli   +14 more
core   +1 more source

The Impact of Monkeypox Virus Infection on Pregnancy Outcome: Clinical Features and Potential Pathogenic Mechanisms

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Monkeypox has garnered significant attention following its emergence in multiple countries and its designation as a global health emergency in 2022. There is a notable deficiency in clinical and experimental data regarding pregnancy outcomes following monkeypox infection.
Jingyi Wu, Fangbin Huang, Qingliang Zheng, Poorani Gurumallesh   +3 more
wiley   +1 more source

Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]

, 1994
To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, John C., Fink, Edwin, Fritz, Hans, Jochum, Marianne, Kohl, Jacek, Siebeck, Matthias, Spannagl, Michael, Spies, Bernd   +7 more
core   +4 more sources

Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury

Frontiers in Immunology, 2019
Background: Ischemia reperfusion injury (IRI) plays a major role in solid organ transplantation. The length of warm ischemia time is critical for the extent of tissue damage in renal IRI.
Li Wang, Vijith Vijayan, Mi-Sun Jang, Anja Thorenz, Robert Greite, Song Rong, Rongjun Chen, Nelli Shushakova, Igor Tudorache, Katja Derlin, Pooja Pradhan, Kukuh Madyaningrana, Nodir Madrahimov, Jan Hinrich Bräsen, Ralf Lichtinghagen, Cees van Kooten, Markus Huber-Lang, Hermann Haller, Stephan Immenschuh, Faikah Gueler   +19 more
doaj   +1 more source

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration [PDF]

, 2014
Cells sense gradients of extracellular cues and generate polarized responses such as cell migration and neurite initiation. There is static information on the intracellular signaling molecules involved in these responses, but how they dynamically ...
Akgoz M, Arai H, Azpiazu I, Bagorda A, Berman DM, Bi E, Bleul CC, Bondar A, Cai H, Cole GM, Daaka Y, Fricker AD, Ge L, Georganta EM, Gerard C, Ghosh P, Hartmann K, Hepler JR, Hewavitharana T, Hollins B, Idevall-Hagren O, Iglesias PA, Irannejad R, James SR, Janetopoulos C, Kamakura S, Kang BH, Karunarathne WK, Karunarathne WK, Karunarathne WK, Kennedy MJ, Klein RS, Koch WJ, Konteatis ZD, Lehmann DM, Levchenko A, Levine H, Li H, Li Z, Lin Y, Ma W, Meili R, Molyneaux KA, N. Gautam, Neptune ER, Neptune ER, O'Neill PR, Parent CA, Patrick R. O'Neill, Peter Van Haastert, Ritter SL, Ross EM, Runne C, Saini DK, Shi C, Spangrude GJ, Srinivasa SP, Takeda K, Toettcher JE, Van Haastert PJ, Wang CJ, Wedegaertner PB, Weiger MC, Wiege K, Xiong Y, Xiong Y, Xu J, Yan J, Yoshiura S, Zhao M   +69 more
core   +2 more sources

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source