Results 41 to 50 of about 1,239,345 (193)

Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 and -3

, 2011
Copyright information:Taken from "Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 and "http://www.jneuroinflammation.com/content/5/1/5Journal of Neuroinflammation 2008;5():5-5.Published online 29 Jan ...
Sunil Thomas (86994), Piali Mukherjee (86993), Giulio Maria Pasinetti (86995)   +2 more
core   +1 more source

Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses. [PDF]

PLoS ONE, 2011
Infusion of human third-party mesenchymal stromal cells (MSCs) appears to be a promising therapy for acute graft-versus-host disease (aGvHD). To date, little is known about how MSCs interact with the body's innate immune system after clinical infusion ...
Guido Moll, Regina Jitschin, Lena von Bahr, Ida Rasmusson-Duprez, Berit Sundberg, Lena Lönnies, Graciela Elgue, Kristina Nilsson-Ekdahl, Dimitrios Mougiakakos, John D Lambris, Olle Ringdén, Katarina Le Blanc, Bo Nilsson   +12 more
doaj   +1 more source

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg74

, 2002
The substantial variations in the responses of cells to the anaphylatoxin C5a and its desarginated form, C5adR74, suggest that more than one type of cell surface receptor for these ligands might exist. However, only a single receptor for C5a and C5adR74,
Monk, Peter N., Peter N. Monk, Stuart A. Cain, Cain, Stuart A.; id_orcid   +3 more
core   +1 more source

Mapping the ligand-binding site on the C5a receptor: Arginine74 of C5a contacts aspartate282 of the C5a receptor

, 2001
The interaction between the anaphylatoxin C5a and its receptor involves two distinct sites. One site is formed by acidic residues at the receptor N-terminus and contributes to only ligand binding. The second site, responsible for activation, is less well
Coughlan, T., Cain, S. A.; id_orcid, Monk, P. N.   +2 more
core   +1 more source

Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds. [PDF]

PLoS ONE, 2017
Diabetic non-healing wounds are a major clinical problem. The mechanisms leading to poor wound healing in diabetes are multifactorial but unresolved inflammation may be a major contributing factor.
Kenji M Cunnion, Neel K Krishna, Haree K Pallera, Angela Pineros-Fernandez, Magdielis Gregory Rivera, Pamela S Hair, Brittany P Lassiter, Ryan Huyck, Mary A Clements, Antoinette F Hood, George T Rodeheaver, Patrick S Cottler, Jerry L Nadler, Anca D Dobrian   +13 more
doaj   +1 more source

Toxoplasma Infection Induces Sustained Up-Regulation of Complement Factor B and C5a Receptor in the Mouse Brain via Microglial Activation: Implication for the Alternative Complement Pathway Activation and Anaphylatoxin Signaling in Cerebral Toxoplasmosis

Frontiers in Immunology, 2021
Toxoplasma gondii is a neurotropic protozoan parasite, which is linked to neurological manifestations in immunocompromised individuals as well as severe neurodevelopmental sequelae in congenital toxoplasmosis.
Noriko Shinjyo, Noriko Shinjyo, Noriko Shinjyo, Kenji Hikosaka, Yasutoshi Kido, Hiroki Yoshida, Kazumi Norose   +6 more
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction

Frontiers in Immunology, 2018
Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory
Hilde L. Orrem, Hilde L. Orrem, Hilde L. Orrem, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Søren E. Pischke, Søren E. Pischke, Søren E. Pischke, Ola Kleveland, Ola Kleveland, Arne Yndestad, Arne Yndestad, Arne Yndestad, Arne Yndestad, Arne Yndestad, Karin Ekholt, Karin Ekholt, Jan K. Damås, Terje Espevik, Bjørn Bendz, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Ida Gregersen, Ida Gregersen, Rune Wiseth, Rune Wiseth, Geir Ø. Andersen, Geir Ø. Andersen, Geir Ø. Andersen, Thor Ueland, Thor Ueland, Thor Ueland, Thor Ueland, Thor Ueland, Lars Gullestad, Lars Gullestad, Lars Gullestad, Pål Aukrust, Pål Aukrust, Pål Aukrust, Pål Aukrust, Andreas Barratt-Due, Andreas Barratt-Due, Andreas Barratt-Due, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes   +54 more
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source