Results 41 to 50 of about 3,783 (170)

Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds. [PDF]

PLoS ONE, 2017
Diabetic non-healing wounds are a major clinical problem. The mechanisms leading to poor wound healing in diabetes are multifactorial but unresolved inflammation may be a major contributing factor.
Kenji M Cunnion, Neel K Krishna, Haree K Pallera, Angela Pineros-Fernandez, Magdielis Gregory Rivera, Pamela S Hair, Brittany P Lassiter, Ryan Huyck, Mary A Clements, Antoinette F Hood, George T Rodeheaver, Patrick S Cottler, Jerry L Nadler, Anca D Dobrian   +13 more
doaj   +1 more source

Toxoplasma Infection Induces Sustained Up-Regulation of Complement Factor B and C5a Receptor in the Mouse Brain via Microglial Activation: Implication for the Alternative Complement Pathway Activation and Anaphylatoxin Signaling in Cerebral Toxoplasmosis

Frontiers in Immunology, 2021
Toxoplasma gondii is a neurotropic protozoan parasite, which is linked to neurological manifestations in immunocompromised individuals as well as severe neurodevelopmental sequelae in congenital toxoplasmosis.
Noriko Shinjyo, Noriko Shinjyo, Noriko Shinjyo, Kenji Hikosaka, Yasutoshi Kido, Hiroki Yoshida, Kazumi Norose   +6 more
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction

Frontiers in Immunology, 2018
Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory
Hilde L. Orrem, Hilde L. Orrem, Hilde L. Orrem, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Søren E. Pischke, Søren E. Pischke, Søren E. Pischke, Ola Kleveland, Ola Kleveland, Arne Yndestad, Arne Yndestad, Arne Yndestad, Arne Yndestad, Arne Yndestad, Karin Ekholt, Karin Ekholt, Jan K. Damås, Terje Espevik, Bjørn Bendz, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Ida Gregersen, Ida Gregersen, Rune Wiseth, Rune Wiseth, Geir Ø. Andersen, Geir Ø. Andersen, Geir Ø. Andersen, Thor Ueland, Thor Ueland, Thor Ueland, Thor Ueland, Thor Ueland, Lars Gullestad, Lars Gullestad, Lars Gullestad, Pål Aukrust, Pål Aukrust, Pål Aukrust, Pål Aukrust, Andreas Barratt-Due, Andreas Barratt-Due, Andreas Barratt-Due, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes   +54 more
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Antagonism of the prostaglandin D₂ receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

Respiratory Research, 2007
Background Mast cell-derived prostaglandin D2 (PGD2), may contribute to eosinophilic inflammation and mucus production in allergic asthma. Chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2), a high affinity receptor for ...
Högberg Thomas, Ulven Trond, Korsgren Magnus, Alenmyr Lisa, Mathiesen Jesper, Uller Lena, Andersson Gunnar, Persson Carl GA, Kostenis Evi   +8 more
doaj   +1 more source

Complement receptor C3aR marks heterogeneous tumor‐associated macrophage states associated with improved survival in IDH‐wildtype glioblastoma

Brain Pathology, EarlyView.
C3aR expression in IDH‐wildtype glioblastoma is predominantly associated with the myeloid/macrophage compartment and heterogeneous macrophage states. C3aR‐high tumors are enriched among MGMT promoter‐methylated tumors and show improved overall survival, although the prognostic association requires independent validation.
Marion Imara, Yosra Bedoui, Théotime Pignolet, Sebastien Freppel, Camille Brochard, Auguste Delattre, David Cappellen, Luc Bauchet, Mohamed Khettab, Franck Ah‐Pine   +9 more
wiley   +1 more source

Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy

Frontiers in Immunology
Pregnancy is a fascinating immunological phenomenon because it allows allogeneic fetal and placental tissues to survive inside the mother. As a component of innate immunity with high inflammatory potential, the complement system must be tightly regulated
Fenna Froehlich, Konstanze Landerholm, Johanna Neeb, Ann-Kathrin Meß, Daniel Leonard Seiler, Tamara Tilburgs, Tamara Tilburgs, Christian Marcel Karsten   +7 more
doaj   +1 more source