Results 41 to 50 of about 6,320 (210)

The N-formyl peptide receptors and the anaphylatoxin C5a receptors: An overview

Biochimie, 2007
Leukocyte recruitment to sites of inflammation and infection is dependent on the presence of a gradient of locally produced chemotactic factors. This review is focused on current knowledge about the activation and regulation of chemoattractant receptors.
Rabiet, Marie-Josèphe, Huet, Emilie, Boulay, François   +2 more
openaire   +4 more sources

Sulfated Tyrosines Contribute to the Formation of the C5a Docking Site of the Human C5a Anaphylatoxin Receptor [PDF]

The Journal of Experimental Medicine, 2001
The complement anaphylatoxin C5a and its seven-transmembrane segment (7TMS) receptor play an important role in host defense and in a number of inflammation-associated pathologies. The NH2-terminal domain of the C5a receptor (C5aR/CD88) contributes substantially to its ability to bind C5a.
M, Farzan, C E, Schnitzler, N, Vasilieva, D, Leung, J, Kuhn, C, Gerard, N P, Gerard, H, Choe   +7 more
openaire   +2 more sources

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. [PDF]

, 2016
The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two seven transmembrane receptors, namely
Blaskovich, M.A., Clark, R.J., Cooper, M.A., Croker, D.E., Floudas, C.A., Halai, R., Kaeslin, G., Monk, P.N., Morikis, D., Schofield, Z., Woodruff, T.M., Wu, M.C.   +11 more
core   +1 more source

Human Plasmacytoid Dendritic Cells Express Receptors for Anaphylatoxins C3a and C5a and Are Chemoattracted to C3a and C5a [PDF]

Journal of Investigative Dermatology, 2006
The presence of plasmacytoid dendritic cells (pDC) was recently demonstrated in lesions of inflammatory skin diseases. Since anaphylatoxins or their precursors were also found in such lesions, we investigated a possible interaction between pDC and anaphylatoxins C3a and C5a.
Gutzmer, Ralf, Koether, Brigitta, Zwirner, Joerg, Dijkstra, Dorothea, Purwar, Rahul, Wittmann, Miriam, Werfel, Thomas   +6 more
openaire   +3 more sources

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. [PDF]

PLoS ONE, 2017
The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts.
Stephanie Bergdolt, Anna Kovtun, Yvonne Hägele, Astrid Liedert, Thorsten Schinke, Michael Amling, Markus Huber-Lang, Anita Ignatius   +7 more
doaj   +1 more source

An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization [PDF]

Journal of Clinical Investigation, 2006
The anaphylatoxins complement component 3a and 5a (C3a and C5a, respectively) are classically seen as proinflammatory mediators of allergic asthma that recruit inflammatory cells, induce edema, and cause bronchoconstriction. A few years ago, controversy arose when it was shown that C5-deficient mice were more susceptible to experimental asthma compared
openaire   +2 more sources

Immunity of turbot Induced by inactivated vaccine of Aeromonas salmonicida from the perspective of DNA methylation

Frontiers in Immunology, 2023
IntroductionDNA methylation was one of the most important modification in epigenetics and played an important role in immune response. Since the introduction of Scophthalmus maximus, the scale of breeding has continued to expand, during which diseases ...
Yingrui Li, Lin Su, Xiaofei Liu, Huimin Guo, Shun Zhou, Yunji Xiu   +5 more
doaj   +1 more source

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

Pulmonary intravascular macrophages: Prime suspects as cellular mediators of porcine CARPA [PDF]

, 2015
Pigs provide a highly sensitive and quantitative in vivo model for complement (C) activation-related pseudoallergy (CARPA), a hypersensitivity reaction caused by some state-of-art nanomedicines.
Aharonson, Aharonson, Atwal, Atwal, Atwal, Atwal, Basu, Basu, Bertram TA, Bertram TA, Bertram TA, Bertram TA, Bhatia, Bhatia, Cantu, Cantu, Carrasco, Carrasco, Carrasco, Carrasco, Castells, Castells, Castells, Castells, Chang, Chang, Chitko, Chitko, DeCamp, DeCamp, Domokos Csukás, Duke, Duke, Dzsi, Dzsi, Ezquerra, Ezquerra, Fine, Fine, Gabizon, Gabizon, Gaca, Gaca, György Wéber, Henson, Henson, Holt, Holt, Humphries, Humphries, Jacobson, Jacobson, János Szebeni, Klingensmith, Klingensmith, Larsen, Larsen, Leifsson, Leifsson, Lohmann, Lohmann, Longworth, Longworth, Longworth, Longworth, László Rosivall, MA, MA, McCarthy, McCarthy, Miot, Miot, Miyamoto, Miyamoto, Mizgerd, Mizgerd, Molina, Molina, Parbhakar, Parbhakar, Parbhakar, Parbhakar, Puchner, Puchner, Rudolf Urbanics, Sakai, Sakai, Schneberger, Schneberger, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Siore, Siore, Sone, Sone, Staub, Staub, Staub, Staub, Staub, Staub, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Thenappan, Thenappan, Warner, Warner, Warner, Warner, Warner, Warner, Warner, Warner, Winkler, Winkler, Winkler, Winkler   +136 more
core   +1 more source

Expression and induction of anaphylatoxin C5a receptors in the rat liver.

Histology and histopathology, 2003
The C5a-anaphylatoxin which is generated by limited proteolysis upon activation of the fifth component of complement may be induced by the classical, the alternative or the lectin pathway. C5a has been shown, under normal conditions, to induce the release of prostanoids from Kupffer cells (KC) and hepatic stellate cells (HSC) and thereby indirectly to ...
Schlaf, G., Schmitz, M., Rothermel, E., Jungermann, K., Schieferdecker, H.L., Götze, O.   +5 more
openaire   +3 more sources