Results 21 to 30 of about 6,320 (210)

C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages

Cells, 2023
The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages.
Oliver Wright, Anna Harris, Van Dien Nguyen, You Zhou, Maxim Durand, Abbie Jayyaratnam, Darren Gormley, Luke A. J. O’Neill, Kathy Triantafilou, Eva Maria Nichols, Lee M. Booty   +10 more
doaj   +1 more source

cDNA Cloning and Characterization of Rat C5a Anaphylatoxin Receptor [PDF]

Microbiology and Immunology, 1997
AbstractActivation of the complement cascade plays an esssential role in the early stages of inflammation. C5a and its receptor are particularly active in anaphylaxis. To determine the pathological roles played by C5a and C5a receptor (C5aR) in rats, we cloned C5aR cDNA and analyzed distribution of its mRNA in various organs including lung from an LPS ...
H, Akatsu, T, Miwa, C, Sakurada, Y, Fukuoka, J A, Ember, T, Yamamoto, T E, Hugli, H, Okada   +7 more
openaire   +2 more sources

A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds [PDF]

, 2010
Complement factor C5a is one of the most powerful pro-inflammatory agents involved in recruitment of leukocytes, activation of phagocytes and other inflammatory responses.
AJ Wright, Anton Bunschoten, B Postma, B Postma, BO Gerber, Carla J. C. de Haas, CE Stotz, DE Epps van, F Blanco, H Lee, J Cavanagh, JH Ippel, JJ Chen, Johan Kemmink, Johannes H. Ippel, John A. W. Kruijtzer, KE Veldkamp, LM Proctor, Louris Feitsma, M Allegretti, M Farzan, PJ Haas, PN Monk, RF Guo, Rob M. J. Liskamp, TS Haque, ZG Chen   +26 more
core   +1 more source

Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

Journal of Neuroinflammation, 2008
Background The complement system is thought to be involved in the pathogenesis of numerous neurological diseases. We previously reported that pre-treatment of murine cortico-hippocampal neuronal cultures with the complement derived anaphylatoxin C5a ...
Thomas Sunil, Mukherjee Piali, Pasinetti Giulio   +2 more
doaj   +1 more source

Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model

Frontiers in Cellular Neuroscience, 2021
Glaucoma is a complex neurodegenerative disease leading to a loss of retinal ganglion cells (RGCs) and optic nerve axons. An activation of the complement system seems to contribute to cell loss in this disease.
Sabrina Reinehr, Johanna D. Doerner, Ana M. Mueller-Buehl, Dennis Koch, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie C. Joachim   +6 more
doaj   +1 more source

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]

, 2015
Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC, Gjertson, D, Mulder, A, Panicker, S, Parry, GC, Reed, EF, Thomas, KA, Valenzuela, NM   +7 more
core   +1 more source

Cloning and characterization of the guinea pig C5a anaphylatoxin receptor: interspecies diversity among the C5a receptors [PDF]

International Immunology, 1998
The anaphylatoxin C5a receptor (C5aR, CD88 in man) plays a prominent role in mediating inflammatory and host defense processes. Direct evidence of C5aR involvement in host defense mechanisms was demonstrated recently using C5aR knockout mice. Mice deficient in C5aR were unable to clear intrapulmonary-instilled bacteria. The guinea pig system is perhaps
Y, Fukuoka, J A, Ember, A, Yasui, T E, Hugli   +3 more
openaire   +2 more sources

Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients

Frontiers in Immunology, 2020
Initially underestimated as platelet dust, extracellular vesicles are continuously gaining interest in the field of inflammation. Various studies addressing inflammatory diseases have shown that microvesicles (MVs) originating from different cell types ...
Ebru Karasu, Julia Demmelmaier, Stephanie Kellermann, Karlheinz Holzmann, Jörg Köhl, Jörg Köhl, Christoph Q. Schmidt, Miriam Kalbitz, Florian Gebhard, Markus S. Huber-Lang, Rebecca Halbgebauer   +10 more
doaj   +1 more source

The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]

, 2018
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J, Graves, Edward E, Kim, Ryan K, Melemenidis, Stavros, Olcina, Monica M   +4 more
core   +1 more source

Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.

PLoS ONE, 2012
The complement anaphylatoxin C5a has a pathogenetic role in endotoxin-induced lung inflammatory injury by regulating phagocytic cell migration and activation.
Kurt Bachmaier, Edgar Guzman, Takeshi Kawamura, Xiaopei Gao, Asrar B Malik   +4 more
doaj   +1 more source