Results 21 to 30 of about 1,239,345 (193)

C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

Acta Neuropathologica Communications, 2022
Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear.
Angela Gomez-Arboledas, Klebea Carvalho, Gabriela Balderrama-Gutierrez, Shu-Hui Chu, Heidi Yahan Liang, Nicole D. Schartz, Purnika Selvan, Tiffany J. Petrisko, Miranda A. Pan, Ali Mortazavi, Andrea J. Tenner   +10 more
doaj   +1 more source

C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages

Cells, 2023
The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages.
Oliver Wright, Anna Harris, Van Dien Nguyen, You Zhou, Maxim Durand, Abbie Jayyaratnam, Darren Gormley, Luke A. J. O’Neill, Kathy Triantafilou, Eva Maria Nichols, Lee M. Booty   +10 more
doaj   +1 more source

cDNA Cloning and Characterization of Rat C5a Anaphylatoxin Receptor [PDF]

Microbiology and Immunology, 1997
AbstractActivation of the complement cascade plays an esssential role in the early stages of inflammation. C5a and its receptor are particularly active in anaphylaxis. To determine the pathological roles played by C5a and C5a receptor (C5aR) in rats, we cloned C5aR cDNA and analyzed distribution of its mRNA in various organs including lung from an LPS ...
H, Akatsu, T, Miwa, C, Sakurada, Y, Fukuoka, J A, Ember, T, Yamamoto, T E, Hugli, H, Okada   +7 more
openaire   +2 more sources

Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model

Frontiers in Cellular Neuroscience, 2021
Glaucoma is a complex neurodegenerative disease leading to a loss of retinal ganglion cells (RGCs) and optic nerve axons. An activation of the complement system seems to contribute to cell loss in this disease.
Sabrina Reinehr, Johanna D. Doerner, Ana M. Mueller-Buehl, Dennis Koch, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie C. Joachim   +6 more
doaj   +1 more source

Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients

Frontiers in Immunology, 2020
Initially underestimated as platelet dust, extracellular vesicles are continuously gaining interest in the field of inflammation. Various studies addressing inflammatory diseases have shown that microvesicles (MVs) originating from different cell types ...
Ebru Karasu, Julia Demmelmaier, Stephanie Kellermann, Karlheinz Holzmann, Jörg Köhl, Jörg Köhl, Christoph Q. Schmidt, Miriam Kalbitz, Florian Gebhard, Markus S. Huber-Lang, Rebecca Halbgebauer   +10 more
doaj   +1 more source

Cloning and characterization of the guinea pig C5a anaphylatoxin receptor: interspecies diversity among the C5a receptors [PDF]

International Immunology, 1998
The anaphylatoxin C5a receptor (C5aR, CD88 in man) plays a prominent role in mediating inflammatory and host defense processes. Direct evidence of C5aR involvement in host defense mechanisms was demonstrated recently using C5aR knockout mice. Mice deficient in C5aR were unable to clear intrapulmonary-instilled bacteria. The guinea pig system is perhaps
Y, Fukuoka, J A, Ember, A, Yasui, T E, Hugli   +3 more
openaire   +2 more sources

Characterization of a Receptor for C5a Anaphylatoxin on Human Eosinophils

Journal of Biological Chemistry, 1989
The complement anaphylatoxin peptide C5a is well known to activate human polymorphonuclear leukocytes through receptor-mediated processes. C5a has also been reported to activate eosinophils for both chemotaxis and hexose uptake. We characterized the receptor molecule for human C5a on human eosinophils and compared it with the receptor on human ...
N P, Gerard, M K, Hodges, J M, Drazen, P F, Weller, C, Gerard   +4 more
openaire   +2 more sources

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

Acta Neuropathologica Communications, 2018
The complement system is a key driver of neuroinflammation. Activation of complement by all pathways, results in the formation of the anaphylatoxin C5a and the membrane attack complex (MAC).
Iliana Michailidou, Aldo Jongejan, Jeroen P. Vreijling, Theodosia Georgakopoulou, Marit B. de Wissel, Ruud A. Wolterman, Patrick Ruizendaal, Ngaisah Klar-Mohamad, Anita E. Grootemaat, Daisy I. Picavet, Vinod Kumar, Cees van Kooten, Trent M. Woodruff, B. Paul Morgan, Nicole N. van der Wel, Valeria Ramaglia, Kees Fluiter, Frank Baas   +17 more
doaj   +1 more source

Treatment of Rare Inflammatory Kidney Diseases: Drugs Targeting the Terminal Complement Pathway

Frontiers in Immunology, 2020
The complement system comprises the frontline of the innate immune system. Triggered by pathogenic surface patterns in different pathways, the cascade concludes with the formation of a membrane attack complex (MAC; complement components C5b to C9) and ...
Marion Anliker-Ort, Marion Anliker-Ort, Jasper Dingemanse, John van den Anker, John van den Anker, Priska Kaufmann   +5 more
doaj   +1 more source

Sulfated Tyrosines Contribute to the Formation of the C5a Docking Site of the Human C5a Anaphylatoxin Receptor [PDF]

The Journal of Experimental Medicine, 2001
The complement anaphylatoxin C5a and its seven-transmembrane segment (7TMS) receptor play an important role in host defense and in a number of inflammation-associated pathologies. The NH2-terminal domain of the C5a receptor (C5aR/CD88) contributes substantially to its ability to bind C5a.
M, Farzan, C E, Schnitzler, N, Vasilieva, D, Leung, J, Kuhn, C, Gerard, N P, Gerard, H, Choe   +7 more
openaire   +2 more sources