Results 11 to 20 of about 1,239,345 (193)

Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin. [PDF]

PLoS ONE, 2012
The complement anaphylatoxin C5a has a pathogenetic role in endotoxin-induced lung inflammatory injury by regulating phagocytic cell migration and activation.
Kurt Bachmaier, Edgar Guzman, Takeshi Kawamura, Xiaopei Gao, Asrar B Malik   +4 more
doaj   +22 more sources

Mast cell activation is characterized by upregulation of a functional anaphylatoxin C5a receptor [PDF]

BMC Immunology, 2008
Background Mast cells (MC) are key effector cells of allergic diseases and resistance to helminthic parasites and induce or amplify diverse innate and adaptive immune responses.
Zwirner Jörg, Kiafard Ziba, Grigat Jasmin, Soruri Afsaneh   +3 more
doaj   +6 more sources

Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo [PDF]

Journal of Neuroinflammation, 2008
Background The complement system is thought to be involved in the pathogenesis of numerous neurological diseases. We previously reported that pre-treatment of murine cortico-hippocampal neuronal cultures with the complement derived anaphylatoxin C5a ...
Thomas Sunil, Mukherjee Piali, Pasinetti Giulio   +2 more
doaj   +2 more sources

C5L2: a controversial receptor of complement anaphylatoxin, C5a

The FASEB Journal, 2012
C5a is the paramount proinflammatory mediator of the complement cascade, and has been previously thought to act only through a single, G‐protein‐coupled, C5a receptor (C5aR; also termed CD88). In 2000, a second C5a receptor, C5L2 (previously known as GPR77), was discovered; yet, despite 12 yr of intensive research, its biological ...
Li, Rui, Coulthard, Liam G., Wu, M. C. L., Taylor, Stephen M., Woodruff, Trent M.   +4 more
openaire   +6 more sources

The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres [PDF]

Journal of Neuroinflammation, 2009
Background In the periphery, C5a acts through the G-protein coupled receptor CD88 to enhance/maintain inflammatory responses. In the brain, CD88 can be expressed on astrocytes, microglia and neurons.
Taylor Stephen M, Sah Pankaj, Lee John D, Sullivan Robert KP, Baiquni Gilang P, Crane James W, Noakes Peter G, Woodruff Trent M   +7 more
doaj   +6 more sources

Activation of B1 B cells by F. tularensis atypical LPS depends on classical complement and C3a. [PDF]

PLoS Pathogens
Francisella tularensis (Ft), a Gram-negative bacterium that causes tularemia, possesses a non-inflammatory atypical LPS (LPSFt) that is highly immunogenic through unknown mechanism.
Guilherme Melo, Carlos Henrique D Barbosa, Elena Magrini, Cecilia Garlanda, Fabio Re   +4 more
doaj   +2 more sources

Characterization of Anaphylatoxin Receptor Expression and C3a/C5a Functions in Anaphylatoxin Receptor Reporter Mice [PDF]

Current Protocols in Immunology, 2020
AbstractThe anaphylatoxins (AT) C3a and C5a are effector molecules of C3 and C5 exerting multiple biologic functions through binding and activation of their cognate G protein−coupled receptors. C3a interacts with the C3a receptor (C3aR), whereas C5a and its primary degradation product C5a‐desArg engage C5aR1 and C5aR2.
Yves, Laumonnier, Christian M, Karsten, Gabriele, Köhl, Jörg, Köhl   +3 more
openaire   +2 more sources

Molecular analysis of the bovine anaphylatoxin C5a receptor [PDF]

Journal of Leukocyte Biology, 2008
AbstractRecruitment of phagocytes to inflammatory sites involves the coordinated action of several chemoattractants, including the anaphylatoxin C5a. While the C5a receptor (C5aR) has been well characterized in humans and rodents, little is known about the bovine C5aR. Here, we report cloning of bovine C5R1, the gene encoding bovine C5aR.
Nemali, Sailasree, Siemsen, Daniel W, Nelson, Laura K., Bunger, Peggy L, Faulkner, Craig L, Rainard, Pascal, Gauss, Katherine A, Jutila, Mark.A, Quinn, Mark T   +8 more
openaire   +3 more sources

A Functional C5a Anaphylatoxin Receptor in a Teleost Species [PDF]

The Journal of Immunology, 2004
Abstract The anaphylatoxins are potent, complement-derived low m.w. proteins that bind to specific seven-transmembrane receptors to elicit and amplify a variety of inflammatory reactions. C5a is the most potent of these phlogistic peptides and is a strong chemoattractant for neutrophils and macrophages/monocytes.
M Claire H, Holland, John D, Lambris
openaire   +2 more sources

The role of C5a-C5aR1 axis in bone pathophysiology: A mini-review

Frontiers in Cell and Developmental Biology, 2022
Bone remodeling is a physiological, dynamic process that mainly depends on the functions of 2 cell types: osteoblasts and osteoclasts. Emerging evidence suggests that complement system is crucially involved in the regulation of functions of these cells ...
Anna Ruocco, Anna Sirico, Rubina Novelli, Silvia Iannelli, Shane Vontelin Van Breda, Diego Kyburz, Paul Hasler, Andrea Aramini, Pier Giorgio Amendola   +8 more
doaj   +1 more source