Results 11 to 20 of about 6,320 (210)

Mast cell activation is characterized by upregulation of a functional anaphylatoxin C5a receptor [PDF]

BMC Immunology, 2008
Background Mast cells (MC) are key effector cells of allergic diseases and resistance to helminthic parasites and induce or amplify diverse innate and adaptive immune responses.
Zwirner Jörg, Kiafard Ziba, Grigat Jasmin, Soruri Afsaneh   +3 more
doaj   +4 more sources

The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres [PDF]

Journal of Neuroinflammation, 2009
Background In the periphery, C5a acts through the G-protein coupled receptor CD88 to enhance/maintain inflammatory responses. In the brain, CD88 can be expressed on astrocytes, microglia and neurons.
Taylor Stephen M, Sah Pankaj, Lee John D, Sullivan Robert KP, Baiquni Gilang P, Crane James W, Noakes Peter G, Woodruff Trent M   +7 more
doaj   +6 more sources

The Complement System in ANCA-Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs. [PDF]

Immun Inflamm Dis
Complement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Sunmboye K, Millan P.
europepmc   +2 more sources

Characterization of Anaphylatoxin Receptor Expression and C3a/C5a Functions in Anaphylatoxin Receptor Reporter Mice [PDF]

Current Protocols in Immunology, 2020
AbstractThe anaphylatoxins (AT) C3a and C5a are effector molecules of C3 and C5 exerting multiple biologic functions through binding and activation of their cognate G protein−coupled receptors. C3a interacts with the C3a receptor (C3aR), whereas C5a and its primary degradation product C5a‐desArg engage C5aR1 and C5aR2.
Yves, Laumonnier, Christian M, Karsten, Gabriele, Köhl, Jörg, Köhl   +3 more
openaire   +2 more sources

Molecular analysis of the bovine anaphylatoxin C5a receptor [PDF]

Journal of Leukocyte Biology, 2008
AbstractRecruitment of phagocytes to inflammatory sites involves the coordinated action of several chemoattractants, including the anaphylatoxin C5a. While the C5a receptor (C5aR) has been well characterized in humans and rodents, little is known about the bovine C5aR. Here, we report cloning of bovine C5R1, the gene encoding bovine C5aR.
Nemali, Sailasree, Siemsen, Daniel W, Nelson, Laura K., Bunger, Peggy L, Faulkner, Craig L, Rainard, Pascal, Gauss, Katherine A, Jutila, Mark.A, Quinn, Mark T   +8 more
openaire   +3 more sources

A Functional C5a Anaphylatoxin Receptor in a Teleost Species [PDF]

The Journal of Immunology, 2004
Abstract The anaphylatoxins are potent, complement-derived low m.w. proteins that bind to specific seven-transmembrane receptors to elicit and amplify a variety of inflammatory reactions. C5a is the most potent of these phlogistic peptides and is a strong chemoattractant for neutrophils and macrophages/monocytes.
M Claire H, Holland, John D, Lambris
openaire   +2 more sources

Complement Proteins C5/C5a, Cathepsin D and Prolactin in Chondrocytes: A Possible Crosstalk in the Pathogenesis of Osteoarthritis

Cells, 2022
Introduction: Both increased activity of the complement system (CS) and the role of the pituitary hormone prolactin (PRL) are implicated in osteoarthritis (OA) pathogenesis.
Sandeep Silawal, Miriam Wagner, Dominik Roth, Thomas Bertsch, Silke Schwarz, Maximilian Willauschus, Markus Gesslein, Jakob Triebel, Gundula Schulze-Tanzil   +8 more
doaj   +1 more source

Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis

Frontiers in Cellular Neuroscience, 2023
BackgroundThe extent of cortical pathology is an important determinant of multiple sclerosis (MS) severity. Cortical demyelination and neurodegeneration are related to inflammation of the overlying leptomeninges, a more inflammatory CSF milieu and with ...
Rhian Evans, Lewis M. Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I. Rees, Denise Fitzgerald, B. Paul Morgan, James W. Neal, Owain W. Howell   +11 more
doaj   +1 more source

The role of C5a-C5aR1 axis in bone pathophysiology: A mini-review

Frontiers in Cell and Developmental Biology, 2022
Bone remodeling is a physiological, dynamic process that mainly depends on the functions of 2 cell types: osteoblasts and osteoclasts. Emerging evidence suggests that complement system is crucially involved in the regulation of functions of these cells ...
Anna Ruocco, Anna Sirico, Rubina Novelli, Silvia Iannelli, Shane Vontelin Van Breda, Diego Kyburz, Paul Hasler, Andrea Aramini, Pier Giorgio Amendola   +8 more
doaj   +1 more source

C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

Acta Neuropathologica Communications, 2022
Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear.
Angela Gomez-Arboledas, Klebea Carvalho, Gabriela Balderrama-Gutierrez, Shu-Hui Chu, Heidi Yahan Liang, Nicole D. Schartz, Purnika Selvan, Tiffany J. Petrisko, Miranda A. Pan, Ali Mortazavi, Andrea J. Tenner   +10 more
doaj   +1 more source