Journal of Neuroinflammation, 2022 Background We previously reported higher plasma levels of complement fragments C3a and C5a in neovascular Age-related Macular Degeneration (nAMD) patients with macular fibrosis.
María Llorián-Salvador +5 more
doaj +1 more source
Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase [PDF]
, 1986 The neutrophil has been implicated as an important mediator of vascular injury, especially after endotoxemia. This study examines neutrophil-mediated injury to human microvascular endothelial cells in vitro. We found that neutrophils stimulated by formyl-
M G Tonnesen +15 more
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Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
Journal of Neuroinflammation, 2022 Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of ...
Klebea Carvalho +10 more
doaj +1 more source
Microvesicles in disease [PDF]
, 2014 On activation cells shed vesicles from their surface by the process of ectocytosis. These micro-vesicles or Ectosomes express phosphatidyl-serine (PS) on their surface, which can elicit a range of biological effects from immune-suppression to the ...
Čumpelik, Arun
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Non-invasive monitoring of renal transplant recipients: Urinary excretion of soluble adhesion molecules and of the complement-split product C4d [PDF]
, 2003 Background: The number of inducible adhesion molecules known to be involved in cell-mediated allograft rejection is still increasing. In addition, recent data describe complement activation during acute humoral allograft rejection.
Lederer, Stephan R. +5 more
core +1 more source
Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice. [PDF]
PLoS ONE, 2014 There is considerable evidence that influenza A virus (IAV) promotes adherence, colonization, and superinfection by S. pneumoniae (Spn) and contributes to the pathogenesis of otitis media (OM).
Hua Hua Tong +8 more
doaj +1 more source
Biomedicines, 2022 The complement system plays a key role in myasthenia gravis (MG). Anti-complement drugs are emerging as effective therapies to treat anti-acetylcholine receptor (AChR) antibody-positive MG patients, though their usage is still limited by the high costs ...
Nicola Iacomino +11 more
doaj +1 more source
Reduced order modeling and analysis of the human complement system. [PDF]
PLoS ONE, 2017 Complement is an important pathway in innate immunity, inflammation, and many disease processes. However, despite its importance, there are few validated mathematical models of complement activation.
Adithya Sagar +4 more
doaj +1 more source
Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]
, 2015 Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Rocha-Ferreira, E +5 more
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Leukocyte sequestration in pulmonary microvessels and lung injury following systemic complement activation in rabbits [PDF]
, 1999 Inflammatory reactions are associated with sequestration of leukocytes in the lung. Complement activation leads to accumulation of leukocytes in alveolar septa and alveoli, to lung edema and hemorrhage.
Kuhnle, Gerhard E. H. +5 more
core +1 more source