Regulatory effects of C5a on IL-17A, IL-17F, and IL-23
Frontiers in Immunology, 2013 The complement anaphylatoxin, C5a, through binding to its receptors (C5aR or C5L2), has important biological properties for recruitment and activation of phagocytes.
Jamison J. Grailer +2 more
doaj +1 more source
Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]
, 2018 Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean +11 more
core +2 more sources
Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin
EBioMedicine, 2016 Thrombus formation leading to vaso-occlusive events is a major cause of death, and involves complex interactions between coagulation, fibrinolytic and innate immune systems.
Jonathan H. Foley +8 more
doaj +1 more source
The interaction between circulating complement proteins and cutaneous microvascular endothelial cells in the development of childhood Henoch-Schönlein Purpura. [PDF]
PLoS ONE, 2015 In addition to IgA, the deposition of complement (C)3 in dermal vessels is commonly found in Henoch-Schönlein purpura (HSP). The aim of this study is to elucidate the role of circulating complement proteins in the pathogenesis of childhood HSP.Plasma ...
Yao-Hsu Yang +5 more
doaj +1 more source
Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis [PDF]
, 2014 The epithelial complement inhibitory proteins (CIPs) cluster of differentiation 46 and 55 (CD46 and CD55) regulate circulating immune complex-mediated complement activation in idiopathic pulmonary fibrosis (IPF). Our previous studies demonstrated that IL-
Cummings, Oscar W. +8 more
core +1 more source
Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937 [PDF]
, 2016 In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells).
Albarracín, Leonardo Miguel +14 more
core +1 more source
Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]
, 2013 This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M +5 more
core +1 more source
PLoS ONE, 2020 Therapy regimens for Chronic lymphocytic leukemia (CLL) commonly include chemotherapy and immunotherapy, which act through complement-mediated-cytotoxicity (CDC) and other mechanisms.
Regina Michelis +8 more
doaj +1 more source
Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients
Cells, 2023 Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler +3 more
doaj +1 more source
Amniotic fluid embolism pathophysiology suggests the new diagnostic armamentarium: β-tryptase and complement fractions C3-C4 are the indispensable working tools [PDF]
, 2015 Amniotic fluid embolism (AFE) is an uncommon obstetric condition involving pregnant women during labor or in the initial stages after delivery. Its incidence is estimated to be around 5.5 cases per 100,000 deliveries.
Busardo', FRANCESCO PAOLO +3 more
core +2 more sources