Results 81 to 90 of about 405,861 (246)

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Cerebrospinal Fluid Profiles in Parkinson’s Disease: No Accumulation of Glucosylceramide, but Significant Downregulation of Active Complement C5 Fragment

Journal of Parkinson’s Disease, 2021
Background: As mutations in glucocerebrosidase 1 ( GBA1 ) are a major risk factor for Parkinson’s disease (PD), decreased GBA1 activity might play an important role in the pathogenesis of the disease.
Yoshiki Niimi, Yasuaki Mizutani, Hisako Akiyama, Hirohisa Watanabe, Ryoichi Shiroki, Yoshio Hirabayashi, Kiyotaka Hoshinaga, Tatsuro Mutoh   +7 more
doaj   +1 more source

Neuronal Expression of a Functional Receptor for the C5a Complement Activation Fragment [PDF]

The Journal of Immunology, 2001
Abstract The present studies were undertaken to determine whether neuronal subsets in normal brains constitutively express functionally competent C5a receptors. In situ hybridization studies coupled with immunohistochemical approaches revealed that most neurons in the hippocampal formation, many pyramidal cortical neurons, and ...
S A, O'Barr, J, Caguioa, D, Gruol, G, Perkins, J A, Ember, T, Hugli, N R, Cooper   +6 more
openaire   +2 more sources

Novel tetronamides derived from mucobromic acid: synthesis, structural elucidation, DFT calculations and phytotoxic activity

Pest Management Science, EarlyView.
The acyclic mucobromic acid, activated by (1S)‐(+)‐10‐camphorsulfonic acid, afforded the chiral compound 1b, precursor for aza‐Michael addition/elimination on the butenolide yielding tetronamides 2b‐7b. Their relative SRSR configuration was confirmed by the spectrometric methods, DFT calculation and statistical methods.
Kamylla CF Faria, Vitor C Baia, Elson S Alvarenga   +2 more
wiley   +1 more source

Pharmacological Stimulation of Phagocytosis Enhances Amyloid Plaque Clearance; Evidence from a Transgenic Mouse Model of ATTR Neuropathy

Frontiers in Molecular Neuroscience, 2017
Hereditary ATTR V30M amyloidosis is a lethal autosomal dominant sensorimotor and autonomic neuropathy caused by deposition of aberrant transthyretin (TTR).
Eleni Fella, Eleni Fella, Kleitos Sokratous, Kleitos Sokratous, Revekka Papacharalambous, Kyriacos Kyriacou, Kyriacos Kyriacou, Joy Phillips, Sam Sanderson, Elena Panayiotou, Theodoros Kyriakides, Theodoros Kyriakides   +11 more
doaj   +1 more source

Complement C5a and C5a receptor 1 mediates glomerular damage in focal segmental glomerulosclerosis

Clinical Immunology
Clinical data and animal models have provided compelling evidence supporting the pathogenic role of complement activation in the progression of focal segmental glomerulosclerosis (FSGS). However, the mechanisms underlying complement-induced podocyte injury and parietal epithelial cell (PEC) activation are not well understood.We evaluated glomerular ...
Xiao-Jie, Gong, Jing, Huang, Yue, Shu, Miao, Wang, Jing, Ji, Li, Yang, Ming-Hui, Zhao, Zhao, Cui   +7 more
openaire   +2 more sources

Complement activation and C5a receptor expression.

, 2015
Concentration of complement components (A) C5a / C5a desArg, (B) C3a / C3a desArg and (C) C4a / C4a desArg after 15 min stimulation with M, SaS A and fMLF in whole blood.
Jörg Zinserling (15631), Josef Zündorf (770918), Thomas Schmidt (168952), Norbert Schnitzler (770915), Alva Brodesser (770914), Thomas Grüger (770916), Kerstin Brandenburg (770917)   +6 more
core   +1 more source

Halting the Progression of Acute Kidney Injury: A Tubular‐Inspired Reusable Detoxifier Against Protein‐Bound Uremic Toxins and Oxidative Stress

SusMat, EarlyView.
This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang, Jiahao Liang, Xijing Yang, Xin Song, Yujie Xiao, Xiran Zhou, Hongyu Xiang, Shujing Wang, Shengjun Cheng, Xianda Liu, Yu Chen, Weifeng Zhao, Changsheng Zhao   +12 more
wiley   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Enhancement of Macrophage Phagocytosis by Complement Component C5a

, 1998
To investigate the modulatory function of complement component C5a in macrophages, the effects of C5a on macrophage phagocytosis were examined by means of fluorescent polystyrene particles and flow cytometry.
Ichinose, Mitsuyuki, Hirota, Akihiko
core   +1 more source