Results 81 to 90 of about 405,066 (236)

Neuronal Expression of a Functional Receptor for the C5a Complement Activation Fragment [PDF]

The Journal of Immunology, 2001
Abstract The present studies were undertaken to determine whether neuronal subsets in normal brains constitutively express functionally competent C5a receptors. In situ hybridization studies coupled with immunohistochemical approaches revealed that most neurons in the hippocampal formation, many pyramidal cortical neurons, and ...
S A, O'Barr, J, Caguioa, D, Gruol, G, Perkins, J A, Ember, T, Hugli, N R, Cooper   +6 more
openaire   +2 more sources

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Complement C5a and C5a receptor 1 mediates glomerular damage in focal segmental glomerulosclerosis

Clinical Immunology
Clinical data and animal models have provided compelling evidence supporting the pathogenic role of complement activation in the progression of focal segmental glomerulosclerosis (FSGS). However, the mechanisms underlying complement-induced podocyte injury and parietal epithelial cell (PEC) activation are not well understood.We evaluated glomerular ...
Xiao-Jie, Gong, Jing, Huang, Yue, Shu, Miao, Wang, Jing, Ji, Li, Yang, Ming-Hui, Zhao, Zhao, Cui   +7 more
openaire   +2 more sources

Complement activation and C5a receptor expression.

, 2015
Concentration of complement components (A) C5a / C5a desArg, (B) C3a / C3a desArg and (C) C4a / C4a desArg after 15 min stimulation with M, SaS A and fMLF in whole blood.
Jörg Zinserling (15631), Josef Zündorf (770918), Thomas Schmidt (168952), Norbert Schnitzler (770915), Alva Brodesser (770914), Thomas Grüger (770916), Kerstin Brandenburg (770917)   +6 more
core   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Enhancement of Macrophage Phagocytosis by Complement Component C5a

, 1998
To investigate the modulatory function of complement component C5a in macrophages, the effects of C5a on macrophage phagocytosis were examined by means of fluorescent polystyrene particles and flow cytometry.
Ichinose, Mitsuyuki, Hirota, Akihiko
core   +1 more source

Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

Journal of Translational Medicine, 2019
Background Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ensure adequate treatment.
Katharina Bröker, Robin Terzenbach, Frank Bentzien, Stefan Lüth, Werner Dammermann   +4 more
doaj   +1 more source

Novel tetronamides derived from mucobromic acid: synthesis, structural elucidation, DFT calculations and phytotoxic activity

Pest Management Science, EarlyView.
The acyclic mucobromic acid, activated by (1S)‐(+)‐10‐camphorsulfonic acid, afforded the chiral compound 1b, precursor for aza‐Michael addition/elimination on the butenolide yielding tetronamides 2b‐7b. Their relative SRSR configuration was confirmed by the spectrometric methods, DFT calculation and statistical methods.
Kamylla CF Faria, Vitor C Baia, Elson S Alvarenga   +2 more
wiley   +1 more source

Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration

Journal of Translational Medicine, 2011
Background Age related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly populations worldwide. Inflammation, among many factors, has been suggested to play an important role in AMD pathogenesis.
Klein Michael L, Chan Chi-Chao, Agron Elvira, Chakrabarty Sagarika, Li Zhiyu, Sen H Nida, Tuo Jingsheng, Meyerle Catherine, Wei Lai, Liu Baoying, Chew Emily, Ferris Frederick, Nussenblatt Robert B   +12 more
doaj   +1 more source