Results 101 to 110 of about 20,066 (195)

Targeting complement C5a to improve radiotherapy sensitivity in non-small cell lung cancer. [PDF]

Transl Lung Cancer Res, 2023
Yuan M, Wang C, Wu Y, Qiao L, Deng G, Liang N, Chen F, Liu L, Chen Y, Yang Y, Wang H, Liu T, Yang X, Zhang Y, Lv Y, Suwinski R, Hu P, Zhang Y, Zhang J.   +18 more
europepmc   +1 more source

Neutrophils from ANCA-associated vasculitis patients show an increased capacity to activate the complement system via the alternative pathway after ANCA stimulation.

PLoS ONE, 2019
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), are autoimmune conditions associated with small vessel inflammation.
Sophie Ohlsson, Lisa Holm, Christina Hansson, Susanne M Ohlsson, Lena Gunnarsson, Åsa Pettersson, Lillemor Skattum   +6 more
doaj   +1 more source

Projecting future damage costs of non‐native species using combined dynamical and cost–density equations

Ecological Applications, Volume 36, Issue 5, July 2026.
Abstract Biological invasions threaten biodiversity, economic stability, and public health, exacerbated by intensive global trade and transport. The economic costs of these invasions have exceeded US$2 trillion globally and continue to increase. Although past invasion costs have been described across various contexts, there are few robust projections ...
Danish A. Ahmed, Corey J. A. Bradshaw, Noor Tahat, Emma J. Hudgins, Pierre Courtois, Philip E. Hulme, Yuya Watari, Ali Serhan Tarkan, Ismael Soto, Phillip J. Haubrock, Paride Balzani, Ross N. Cuthbert   +11 more
wiley   +1 more source

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source

Complement C5a inhibition: a new form of COVID-19 treatment for mechanically ventilated patients? [PDF]

Lancet Respir Med, 2022
Kalil AC, Proschan M.
europepmc   +1 more source

Reduced Complement and Granulocyte Activation by α‐Gal Knockout Porcine Pericardium for Bioprosthetic Heart Valves: A Pilot Hemocompatibility Study

Journal of Biomedical Materials Research Part A, Volume 114, Issue 7, July 2026.
Genetically modified, α‐Gal‐depleted porcine pericardium and wild type tissues are investigated for hemocompatibility and material properties such as mechanobiology and ECM profile to carve out the suitability of the gene‐modified tissue as material for biological heart valve prostheses. ABSTRACT Xenogeneic pericardium is the main source for biological
Claudia Dittfeld, Elisabeth Kemter, Barbara Kessler, Eckhard Wolf, Anett Jannasch, Claudia Sperling, Sems‐Malte Tugtekin, Manfred F. Maitz   +7 more
wiley   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages. [PDF]

J Innate Immun, 2023
Wu KC, Condon ND, Hill TA, Reid RC, Fairlie DP, Lim J.   +5 more
europepmc   +1 more source

C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study

International Journal of Retina and Vitreous
Background Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as
Paula Basso Dias, Iara Messias-Reason, Germano Ramos Boff, Kenzo Hokazono, Renato Nisihara   +4 more
doaj   +1 more source

Evidence for a Two‐Step Model for Activation of GPR25 by the Chemoattractant CXCL17

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT CXCL17 was recently reported to activate GPR25, a receptor expressed by T‐regulatory cells. Although classified as a chemokine, the activity of CXCL17 is ablated by minor C‐terminal truncation, suggesting a novel mode of receptor activation. We set out to test this hypothesis by mutagenesis. GPR25 was expressed in the murine pre‐B cell line L1.
Wuqing Yang, Sean P. Giblin, James E. Pease   +2 more
wiley   +1 more source