Results 101 to 110 of about 405,066 (236)

Deficiency of high‐molecular‐weight von Willebrand factor mitigates thrombo‐complement injury in an LPS‐induced TMA‐like mouse model

VIEW, EarlyView.
Reduction of high‐molecular‐weight von Willebrand factor disrupts the platelet–complement amplification loop, attenuating microvascular thrombosis, complement deposition, endothelial injury, and organ damage in complement‐mediated thrombotic microangiopathy.
Yang Li, Chihao Zhang, Xiaoqian Xu, Sicong Wang, Xiaofan Hu, Junjie Yao, Xi Wu, Difeng Zhu, Qian Liang, Yeling Lu, Yu Liu, Guanqun Xu, Jiakuan Zhou, Qiulan Ding, Wenman Wu, Ya Li, Jing Dai, Xuefeng Wang   +17 more
wiley   +1 more source

Complement 3a and Complement 5a as Biochemical Markers in Diabetic Nephropathy [PDF]

International Journal of Medical Arts
Background: Diabetes mellitus [DM] is growing into a global epidemic and diabetic nephropathy [DN] is one of its most feared complications. Inflammation is an important mechanism in the pathogenesis of DN and many studies have pointed to anaphylatoxins ...
Safwat Ahmed, Alsayed Alsayed, Mohammed Aref, Ahmad Alkot   +3 more
doaj   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Granulomatosis with polyangiitis and microscopic polyangiitis: pathogenesis and clinical manifestations

Современная ревматология
This literature review addresses the epidemiology, genetic markers, pathogenesis, clinical features, and diagnostic approaches of granulomatosis with polyangiitis and microscopic polyangiitis – both antineutrophil cytoplasmic antibody-associated ...
T. M. Reshetnyak, E. N. Vorkel, K. S. Nurbayeva, A. M. Lila   +3 more
doaj   +1 more source

Complementing Cancer Metastasis

Frontiers in Immunology, 2018
Complement is an effector of innate immunity and a bridge connecting innate immunity and subsequent adaptive immune responses. It is essential for protection against infections and for orchestrating inflammatory responses.
Dawn M. Kochanek, Shanawaz M. Ghouse, Magdalena M. Karbowniczek, Maciej M. Markiewski   +3 more
doaj   +1 more source

Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2

, 2014
The complement activation product, C5a, is a pivotal member of the innate immune response; however, a diverse number of nonimmune functions are now being ascribed to C5a signaling, including roles during embryonic development.
Hawksworth, Owen A., Coulthard, Liam G., Woodruff, Trent M., Taylor, Stephen M., Wolvetang, Ernst J.   +4 more
core   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease

, 2013
AIMS: Failure of vein graft conduits due to vein graft thickening, accelerated atherosclerosis, and subsequent plaque rupture is applicable to 50% of all vein grafts within 10 years.
Kuiper, J., Wezel, A., Vries, M.R. de, Woodruff, T.M., Quax, P.H.A., Schepers, A., de Vries, M.R., van Wezel, A., Niessen, H.W.M., Hamming, J.F., Santbrink, P.J. van, Schepers, A, van Santbrink, P.J., Bot, I.   +13 more
core   +1 more source

The complement system component C5a produces thermal hyperalgesia via macrophage-to-nociceptor signaling that requires NGF and TRPV1 [PDF]

, 2016
The complement cascade is a principal component of innate immunity. Recent studies have underscored the importance of C5a and other components of the complement system in inflammatory and neuropathic pain, although the underlying mechanisms are largely ...
Shepherd, Andrew J., Usachev, Yuriy M, David Clark, J., Warwick, Charles A, Shepherd, Andrew J, Clark, J. David, Mohapatra, Durga P., Warwick, Charles A., Shi, Xiaoyu, Shutov, Leonid P., Usachev, Yuriy M., Shutov, Leonid P, Mohapatra, Durga P, Gnanasekaran, Aswini, Woodruff, Trent M., Woodruff, Trent M   +15 more
core   +1 more source