Results 101 to 110 of about 405,861 (246)

Phenotype- and age-associated variations in non-specific agglutinins and complement components (C3 and C5a) in camels: Implications for transfusion compatibility and immune function [PDF]

Veterinary World
Background and Aim: Blood transfusion in camels is hindered by poorly understood blood group systems, non-specific agglutinins, and a lack of standardized cross-matching protocols.
Yousef M. Alharbi
doaj   +1 more source

The effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients

Intensive Care Medicine Experimental, 2020
Background Mechanical ventilation can induce or even worsen lung injury, at least in part via overdistension caused by too large volumes or too high pressures.
Friso M. de Beer, Luuk Wieske, Gerard van Mierlo, Diana Wouters, Sacha Zeerleder, Lieuwe D. Bos, Nicole P. Juffermans, Marcus J. Schultz, Tom van der Poll, Wim K. Lagrand, Janneke Horn, for the BASIC–study group   +11 more
doaj   +1 more source

Complement factor C5a and C5a receptor contribute to morphine tolerance and withdrawal-induced hyperalgesia in rats

Experimental and Therapeutic Medicine, 2012
Morphine is a potent opioid analgesic. However, the repeated use of morphine causes tolerance and hyperalgesia. Neuroinflammation has been reported to be involved in morphine tolerance and withdrawal-induced hyperalgesia. The complement system is a crucial effector mechanism of immune responses.
LI, YAN-HUA, JIN, HUA, XU, JING-SHU, GUO, GUANG-QIONG, CHEN, DA-LIN, BO, YUN   +5 more
openaire   +3 more sources

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Granulomatosis with polyangiitis and microscopic polyangiitis: pathogenesis and clinical manifestations

Современная ревматология
This literature review addresses the epidemiology, genetic markers, pathogenesis, clinical features, and diagnostic approaches of granulomatosis with polyangiitis and microscopic polyangiitis – both antineutrophil cytoplasmic antibody-associated ...
T. M. Reshetnyak, E. N. Vorkel, K. S. Nurbayeva, A. M. Lila   +3 more
doaj   +1 more source

Complement 3a and Complement 5a as Biochemical Markers in Diabetic Nephropathy [PDF]

International Journal of Medical Arts
Background: Diabetes mellitus [DM] is growing into a global epidemic and diabetic nephropathy [DN] is one of its most feared complications. Inflammation is an important mechanism in the pathogenesis of DN and many studies have pointed to anaphylatoxins ...
Safwat Ahmed, Alsayed Alsayed, Mohammed Aref, Ahmad Alkot   +3 more
doaj   +1 more source

The Complement System in Post‐Transplant Kidney Injury

Organ Medicine, EarlyView.
Mengsi Hu
wiley   +1 more source

Complement receptor C3aR marks heterogeneous tumor‐associated macrophage states associated with improved survival in IDH‐wildtype glioblastoma

Brain Pathology, EarlyView.
C3aR expression in IDH‐wildtype glioblastoma is predominantly associated with the myeloid/macrophage compartment and heterogeneous macrophage states. C3aR‐high tumors are enriched among MGMT promoter‐methylated tumors and show improved overall survival, although the prognostic association requires independent validation.
Marion Imara, Yosra Bedoui, Théotime Pignolet, Sebastien Freppel, Camille Brochard, Auguste Delattre, David Cappellen, Luc Bauchet, Mohamed Khettab, Franck Ah‐Pine   +9 more
wiley   +1 more source

Kininase I drives angiotensin II‐induced hypertension through activation of the bradykinin B1 receptor

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kininase I, comprising carboxypeptidase N (CPN) and carboxypeptidase M, regulates kinin activity and is up‐regulated during injury, inflammation and immune activation. Under these conditions, kininase I converts bradykinin and kallidin into des‐Arg kinins, primary endogenous agonists of the bradykinin B1 receptor (R ...
Acacia White, Drew Theobald, Alexandra Johnston, David A. Tulis, Johanna Hannan, Srinivas Sriramula   +5 more
wiley   +1 more source

Complementing Cancer Metastasis

Frontiers in Immunology, 2018
Complement is an effector of innate immunity and a bridge connecting innate immunity and subsequent adaptive immune responses. It is essential for protection against infections and for orchestrating inflammatory responses.
Dawn M. Kochanek, Shanawaz M. Ghouse, Magdalena M. Karbowniczek, Maciej M. Markiewski   +3 more
doaj   +1 more source