Results 111 to 120 of about 405,861 (246)

Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2

, 2014
The complement activation product, C5a, is a pivotal member of the innate immune response; however, a diverse number of nonimmune functions are now being ascribed to C5a signaling, including roles during embryonic development.
Hawksworth, Owen A., Coulthard, Liam G., Woodruff, Trent M., Taylor, Stephen M., Wolvetang, Ernst J.   +4 more
core   +1 more source

Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses [PDF]

, 2017
Contains fulltext : 177337.pdf (Publisher’s version ) (Open Access)The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 ...
Heuvel, L.P.W.J. van den, Thomas, A.M., Thomas, Anub Mathew, Alice Gustavsen, Nilsson, Per, Barratt-Due, Andreas, Volokhina, E.B., van den Heuvel, Lambertus P., Elena B. Volokhina, Bergseth, Grethe, Gustavsen, A., Bergseth, G., Gustavsen, Alice, Mollnes, T.E., Barratt-Due, A., Nilsson, P.H., Nilsson, Per H., Tom E. Mollnes, Grethe Bergseth, Lambertus P. van den Heuvel, Anub Mathew Thomas, Volokhina, Elena B., Mollnes, Tom Eirik, Bergseth, Grete, Andreas Barratt-Due, Mollnes, Tom E., Per H. Nilsson   +26 more
core   +2 more sources

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease

, 2013
AIMS: Failure of vein graft conduits due to vein graft thickening, accelerated atherosclerosis, and subsequent plaque rupture is applicable to 50% of all vein grafts within 10 years.
Kuiper, J., Wezel, A., Vries, M.R. de, Woodruff, T.M., Quax, P.H.A., Schepers, A., de Vries, M.R., van Wezel, A., Niessen, H.W.M., Hamming, J.F., Santbrink, P.J. van, Schepers, A, van Santbrink, P.J., Bot, I.   +13 more
core   +1 more source

The complement system component C5a produces thermal hyperalgesia via macrophage-to-nociceptor signaling that requires NGF and TRPV1 [PDF]

, 2016
The complement cascade is a principal component of innate immunity. Recent studies have underscored the importance of C5a and other components of the complement system in inflammatory and neuropathic pain, although the underlying mechanisms are largely ...
Shepherd, Andrew J., Usachev, Yuriy M, David Clark, J., Warwick, Charles A, Shepherd, Andrew J, Clark, J. David, Mohapatra, Durga P., Warwick, Charles A., Shi, Xiaoyu, Shutov, Leonid P., Usachev, Yuriy M., Shutov, Leonid P, Mohapatra, Durga P, Gnanasekaran, Aswini, Woodruff, Trent M., Woodruff, Trent M   +15 more
core   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Supplementary Material for: Spatiotemporal Dynamics of Complement C5a Production within Bacterial Extracellular Polymeric Substance

, 2017
Opsonization and anaphylatoxin production are early events in the innate response to bacterial pathogens. Opsonization alone is frequently not lethal and production of anaphy-latoxins, especially C5a, allows for recruitment of cellular defenses ...
Bortz D.M. (4136542), Conrad E.C. (4136548), Hsu Y.-Y. (4136545), Younger J.G. (4136539)   +3 more
core   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

Increased concentration of the complement split product C5a in acute pyelonephritis during pregnancy

, 2005
OBJECTIVE: Pregnant women with acute pyelonephritis develop acute respiratory distress syndrome (ARDS) more frequently than non-pregnant women. The reasons for this remain unknown.
Goncalves, Luis, Chaiworapongsa, Tinnakorn, Richani, Karina, Espinoza, Jimmy, Mazor, Moshe, Soto, Eleazar, Kim, Yeon Mee, Nien, Jyh Kae, Hong, Joon-Seok, Edwin, Samuel, Romero, Roberto   +10 more
core   +1 more source