Results 131 to 140 of about 36,145 (228)

Neopterin, PMN Elastase, and Complement Components as Monitoring Parameters in Women with the Syndrome of Hemolysis, Elevated Liver Enzymes and Low Platelet Count

Pteridines, 1993
Preeclampsia is a pregnancy induced hypertensive disease with an incidence of about 5% in primigravida and it significantly contributes to maternal and neonatal morbidity and mortality. The primary cause remains unknown but might be immunologic.
Haeger Magnus, Unander Margareta, Bengtsson Anders   +2 more
doaj   +1 more source

Therapeutic Potential of Targeting Complement C5a Receptors in Diabetic Kidney Disease. [PDF]

Int J Mol Sci, 2023
Trambas IA, Coughlan MT, Tan SM.
europepmc   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Targeting complement C5a to improve radiotherapy sensitivity in non-small cell lung cancer. [PDF]

Transl Lung Cancer Res, 2023
Yuan M, Wang C, Wu Y, Qiao L, Deng G, Liang N, Chen F, Liu L, Chen Y, Yang Y, Wang H, Liu T, Yang X, Zhang Y, Lv Y, Suwinski R, Hu P, Zhang Y, Zhang J.   +18 more
europepmc   +1 more source

Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan, Vishnu Sharma, Venkatesh Atul Bhattaram, Xiaolei Pan, Justin Earp, Yun Wang, Jiang Liu, Hao Zhu   +7 more
wiley   +1 more source

Complement C5a inhibition: a new form of COVID-19 treatment for mechanically ventilated patients? [PDF]

Lancet Respir Med, 2022
Kalil AC, Proschan M.
europepmc   +1 more source

Neutrophils from ANCA-associated vasculitis patients show an increased capacity to activate the complement system via the alternative pathway after ANCA stimulation.

PLoS ONE, 2019
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), are autoimmune conditions associated with small vessel inflammation.
Sophie Ohlsson, Lisa Holm, Christina Hansson, Susanne M Ohlsson, Lena Gunnarsson, Åsa Pettersson, Lillemor Skattum   +6 more
doaj   +1 more source

Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages. [PDF]

J Innate Immun, 2023
Wu KC, Condon ND, Hill TA, Reid RC, Fairlie DP, Lim J.   +5 more
europepmc   +1 more source

Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors. [PDF]

Sci Rep, 2022
Coughlan MT, Ziemann M, Laskowski A, Woodruff TM, Tan SM.   +4 more
europepmc   +1 more source

In Vivo Pharmacodynamic Method to Assess Complement C5a Receptor Antagonist Efficacy. [PDF]

ACS Pharmacol Transl Sci, 2022
Cui CS, Kumar V, Gorman DM, Clark RJ, Lee JD, Woodruff TM.   +5 more
europepmc   +1 more source