Results 131 to 140 of about 405,066 (236)

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

In Vivo Pharmacodynamic Method to Assess Complement C5a Receptor Antagonist Efficacy. [PDF]

ACS Pharmacol Transl Sci, 2022
Cui CS, Kumar V, Gorman DM, Clark RJ, Lee JD, Woodruff TM.   +5 more
europepmc   +1 more source

Aseptic meningitis due to intravenous immunoglobulin therapy (IVIG) in therapy‐refractory pyoderma gangraenosum

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Katharina A. Kälber, Knut Schäkel, Alexander Enk, Julia K. Winkler   +3 more
wiley   +1 more source

The Oral‐Gut Axis: Bidirectional Interactions Between Microbiome and Diseases

Journal of Periodontal Research, EarlyView.
This study aims to summarize the mechanisms underlying ectopic colonization of the gut by oral pathobionts and the microbial and host factors that regulate this process. ABSTRACT Increased colonization of typically oral microorganisms is frequently observed in the gut mucosa or lumen of individuals with gastrointestinal disorders, including patients ...
Shinya Ebihara, Nobuhiko Kamada
wiley   +1 more source

C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study

International Journal of Retina and Vitreous
Background Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as
Paula Basso Dias, Iara Messias-Reason, Germano Ramos Boff, Kenzo Hokazono, Renato Nisihara   +4 more
doaj   +1 more source

Complement 5 (C5); C5a; C5a receptor [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment. [PDF]

Bioact Mater, 2023
Gan Z, Xiao Z, Zhang Z, Li Y, Liu C, Chen X, Liu Y, Wu D, Liu C, Shuai X, Cao Y.   +10 more
europepmc   +1 more source

Mild Hypothermia Alleviates Complement C5a-Induced Neuronal Autophagy During Brain Ischemia-Reperfusion Injury After Cardiac Arrest. [PDF]

Cell Mol Neurobiol, 2023
Wang L, Sun Y, Kong F, Jiang Y, An M, Jin B, Cao D, Li R, Guan X, Liang S, Abudurexiti S, Gong P.   +11 more
europepmc   +1 more source

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation. [PDF]

Int J Oral Sci, 2022
Irfan M, Kim JH, Marzban H, Reed DA, George A, Cooper LF, Chung S.   +6 more
europepmc   +1 more source