Results 141 to 150 of about 405,066 (236)

Complement C5a Measurement [PDF]

, 2020
openaire   +1 more source

Complement protein C5a enhances the β-amyloid-induced neuro-inflammatory response in microglia in Alzheimer’s disease

, 2018
Objective: The dysregulation of neuro-inflammation is one of the attributes of the pathogenesis of Alzheimer’s disease (AD). Over-expression of complement proteins co-localizes with neurofibrillary tangles, thereby indicating that a complement system may
Xiao Huang, Wei Xi, Chen-yun Gu, Xiao-qun An   +3 more
core   +1 more source

Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis. [PDF]

Thromb J, 2022
Chen Y, Li X, Lin X, Liang H, Liu X, Zhang X, Zhang Q, Zhou F, Yu C, Lei L, Xiu J.   +10 more
europepmc   +1 more source

A First‐in‐Japanese Phase 1, Double‐Blind, Placebo‐Controlled, Parallel‐Cohort Study of Sefaxersen, an Antisense Oligonucleotide Targeting Complement Factor B, in Healthy Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 9, September 2026.
Abstract Increased activity in the complement alternative pathway (AP) plays a key role in diseases such as IgA nephropathy (IgAN). This first‐in‐Japanese double‐blind Phase 1 study investigated the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of sefaxersen (RO7434656), an antisense oligonucleotide targeting complement factor ...
Takakazu Sato, Hiroyuki Fukase, Takaaki Ishida, Arisa Karasawa   +3 more
wiley   +1 more source

Complement 5a (C5a) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Complement C5a and adrenal cell function: examining a potential mechanism of adrenal dysfunction in sepsis [PDF]

The complement system is critically involved in the pathogenesis of sepsis. In particular, complement anaphylatoxin C5a is generated in excess during sepsis, leading to cellular dysfunction.
Mrozewski, Lucas
core   +1 more source

Complement Involvement in Renal Transplantation [PDF]

, 2015
The complement system is involved in several renal diseases and in renal transplantation (RTx). The authors review the complement cascade and its involvement in innate and adaptive immunity in the field of RTx.
Maurizio Salvadori, Elisabetta Bertoni, Giuseppina Rosso   +2 more
core  

Complement C5a and Clinical Markers as Predictors of COVID-19 Disease Severity and Mortality in a Multi-Ethnic Population. [PDF]

Front Immunol, 2021
Cyprian FS, Suleman M, Abdelhafez I, Doudin A, Masud Danjuma M, Mir FA, Parray A, Yousaf Z, Siddiqui MYA, Abdelmajid A, Mulhim M, Al-Shokri S, Abukhattab M, Shaheen R, Elkord E, Al-Khal AL, Elzouki AN, Girardi G.   +17 more
europepmc   +1 more source

Cancer cell‐selective ectopic expression of CD20 as an antigen enables rituximab repurposing for solid tumour immunotherapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
A recombinant AAV delivered tumour gene therapy. NF‐κB drives tumour‐selective antigen (e.g., CD20) expression. Ectopic CD20 enables rituximab repurposing to solid tumours. ADCC, ADCP, and CDC contribute to the antitumour activity. Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐
Ziyan Kong, Yile Wang, Yunqi Zhao, Lu Wang, Zhimin Fan, Yongqian Shu, Jinke Wang   +6 more
wiley   +1 more source

Integrative Transcriptomic Analysis and Functional Validation Implicate GPT2 in Glycolytic Regulation in Polycystic Ovary Syndrome

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Integrating GEO transcriptomic datasets, machine‐learning algorithms, GSVA, multilayer regulatory network and immune infiltration analyses, this study revealed metabolic‐immune disturbance and aberrant ovarian steroidogenesis in polycystic ovary syndrome (PCOS).
Meili Xi, Rongkui Luo, Jiarong Zhang, Weihong Huang, Li Ma, Yunyan Sun, Aimin Ren   +6 more
wiley   +1 more source