Results 141 to 150 of about 405,861 (246)
Immunology, Volume 179, Issue 3, Page 444-456, November 2026.We identify four distinct C5 inhibitory epitopes, including two novel antibodies that selectively block membrane attack complex (MAC) assembly while preserving C5 cleavage and C5a generation. These findings establish selective MAC inhibition as a new therapeutic strategy for complement‐mediated diseases.
Rebekah Sian Cooke +5 more
wiley +1 more source
Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment. [PDF]
Bioact Mater, 2023 Gan Z +10 more
europepmc +1 more source
ACR Open Rheumatology, Volume 8, Issue 10, October 2026.Objective Complement activation, particularly through the C5a–C5a receptor axis, plays a pivotal role in the pathogenesis of antineutrophil cytoplasmic antibody–associated vasculitis (AAV) and may represent an important therapeutic target. Avacopan, an oral C5a receptor antagonist, was the first therapy targeting this pathway to enter in clinical ...
Luca Quartuccio +33 more
wiley +1 more source
Mild Hypothermia Alleviates Complement C5a-Induced Neuronal Autophagy During Brain Ischemia-Reperfusion Injury After Cardiac Arrest. [PDF]
Cell Mol Neurobiol, 2023 Wang L +11 more
europepmc +1 more source
From Molecular Targets to Advanced Delivery Systems: Aptamers for Precision Ocular Therapeutics
Advanced Therapeutics, Volume 9, Issue 10, October 2026.Aptamer‐based strategies are revolutionizing ocular disease management through highly specific molecular recognition of disease specific molecular targets. This review systematically integrates therapeutic aptamer sequences, diagnostic aptasensor platforms, and targeted delivery strategies, highlighting design principles, ocular bioavailability ...
Minal Thacker +4 more
wiley +1 more source
The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation. [PDF]
Int J Oral Sci, 2022 Irfan M +6 more
europepmc +1 more source
, 2018 Objective: The dysregulation of neuro-inflammation is one of the attributes of the pathogenesis of Alzheimer’s disease (AD). Over-expression of complement proteins co-localizes with neurofibrillary tangles, thereby indicating that a complement system may
Xiao Huang +3 more
core +1 more source
Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis. [PDF]
Thromb J, 2022 Chen Y +10 more
europepmc +1 more source