Results 161 to 170 of about 20,066 (195)
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Emerging Insights into the Structure and Function of Complement C5a Receptors
Trends in Biochemical Sciences, 2020Complement factor C5a is an integral constituent of the complement cascade critically involved in the innate immune response, and it exerts its functions via two distinct receptors, C5aR1 and C5aR2. While C5aR1 is a prototypical G-protein-coupled receptor (GPCR), C5aR2 lacks functional coupling to heterotrimeric G proteins, although both receptors ...
Shubhi Pandey +2 more
exaly +6 more sources
Complement C5a: Impact on the field of veterinary medicine
Veterinary Journal, 2012Complement C5a is a pro-inflammatory polypeptide produced during activation of the complement cascade in response to foreign antigens or tissue damage secondary to physical or chemical injury. C5a, via activation of the C5a receptor (C5aR or CD88), is a major inflammatory mediator involved in a number of diseases, including some of veterinary relevance.
Barbara E Rolfe +2 more
exaly +6 more sources
Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge [PDF]
Frontiers in Immunology, 2021 FRANCISCO Carmona-Torre +2 more
exaly +2 more sources
Journal of Cellular Biochemistry, 2022
AbstractThe complement system is central to the rapid immune response witnessed in vertebrates and invertebrates, which plays a crucial role in physiology and pathophysiology. Complement activation fuels the proteolytic cascade, which produces several complement fragments that interacts with a distinct set of complement receptors.
Aurosikha Das +3 more
openaire +2 more sources
AbstractThe complement system is central to the rapid immune response witnessed in vertebrates and invertebrates, which plays a crucial role in physiology and pathophysiology. Complement activation fuels the proteolytic cascade, which produces several complement fragments that interacts with a distinct set of complement receptors.
Aurosikha Das +3 more
openaire +2 more sources
Involvement of complement peptides C3a and C5a in osteoarthritis pathology
Peptides, 2022Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five diseases in Germany causing the highest suffering of the patients and cost for the society. The quality of life of OA patients is severely compromised, and adequate therapy is lacking owing to a knowledge gap that acts as a major barrier to finding safe and ...
Nicole, Schäfer, Susanne, Grässel
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Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy [PDF]
Cancer Cell, 2018 Dhaarini Murugan +2 more
exaly +2 more sources
C5L2: a controversial receptor of complement anaphylatoxin, C5a
The FASEB Journal, 2012C5a is the paramount proinflammatory mediator of the complement cascade, and has been previously thought to act only through a single, G‐protein‐coupled, C5a receptor (C5aR; also termed CD88). In 2000, a second C5a receptor, C5L2 (previously known as GPR77), was discovered; yet, despite 12 yr of intensive research, its biological ...
Li, Rui +4 more
openaire +5 more sources
Circular dichroism of C5a anaphylatoxin of porcine complement
Biochemical and Biophysical Research Communications, 1974Abstract The far-ultraviolet circular dichroism spectrum of C5a anaphylatoxin of porcine complement implies that it has a substantial content of helical structure. The circular dichroism spectra of C5a in the 200–250 nm region at pH 7.2 and 3.7 are nearly identical and resemble those of C3a anaphylatoxin.
W T, Morgan +2 more
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Immunology & Cell Biology, 2013
Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like‐2 (C5L2) receptor. Here we hypothesized that activation of C5aR might lead to heteromer formation with C5L2, as a downregulatory
Croker, Daniel E. +3 more
openaire +5 more sources
Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like‐2 (C5L2) receptor. Here we hypothesized that activation of C5aR might lead to heteromer formation with C5L2, as a downregulatory
Croker, Daniel E. +3 more
openaire +5 more sources
Complement C5A regulates prolabor mediators in human placenta.
Biology of reproduction, 2012Human preterm and term parturition is associated with inflammatory cascades in the uteroplacental unit. Activation of the complement cascade releases potent proinflammatory mediators, including the anaphylatoxin C5a, which exerts its biological effects through its receptors, C5AR (also known as CD88) and C5L2, official symbol GPR77.
Lappas, Martha +3 more
openaire +5 more sources