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The Complement C3a and C3a Receptor Pathway in Kidney Diseases [PDF]
Frontiers in Immunology, 2020 The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role.
Zhao Cui +2 more
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Anaphylatoxin C3a receptors in asthma [PDF]
Respiratory Research, 2005 The complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of complement activation, has long been known to activate mast cells, basophils ...
Panettieri Reynold A, Ali Hydar
doaj +7 more sources
Anaphylatoxin C3a but not C3a(desArg) is a chemotaxin for the mouse macrophage cell line J774 [PDF]
European Journal of Immunology, 1998 Varying results have been published regarding the functional reactivity of different cell types, including human monocytes, to the anaphylatoxin C3a and its degradation product C3a(desArg). To further delineate the functions of C3a and C3a(desArg) on this cell type we used the murine macrophage (Mø) cell line J774A.1 which is known to respond to the ...
Thomas Werfel, O Götze, J Zwirner
exaly +3 more sources
The Role of the C3a-C3aR Pathway in Diseases: Latest Research Advances [PDF]
Mediators of InflammationC3a is a key active factor in the complement system, capable of participating in various physiological and pathological processes by binding to its C3a receptor (C3aR).
Xiangwei Bo +3 more
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C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study [PDF]
International Journal of Retina and VitreousBackground Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as
Paula Basso Dias +4 more
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Urinary C3 levels associated with sepsis and acute kidney injury-A pilot study.
PLoS ONE, 2021 Acute kidney injury (AKI) is an abrupt deterioration of renal function often caused by severe clinical disease such as sepsis, and patients require intensive care.
Sahra Pajenda +7 more
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Changes of complement fragment C3a and its receptor in lung injury induced by silica nanoparticles
环境与职业医学, 2023 BackgroundSilica nanoparticles (SiNPs) enter the human body through respiratory tract, digestive tract, and skin, causing body damage. Lung is one of the main damaged organs.
Sifan ZHOU +6 more
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Frontiers in Bioscience-Landmark, 2023 Background: Renin-dependent hypertension with tubulointerstitial injury remains a problem with high prevalence in the clinic. However, whether and how renin participates in tubulointerstitial injury remains incompletely understood.
Chongjian Wang +8 more
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Horticulturae, 2022 Compact bunches have been often associated with higher susceptibility to Botrytis cinerea and therefore reduction in berry quality in grapevine. The objective of this study was to evaluate three management methods (early leaf removal, gibberellic acid ...
Mario Wegher +2 more
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Cytolysis of fibroblasts by C3a [PDF]
British Journal of Cancer, 1980 C3a was found to be more cytolytic to transformed than to primary fibroblast cultures from mouse and man. Fibroblasts made quiescent with caffeine were lysed by the same concentrations of C3a as untreated cells. These findings may have implications in tumour immunity.
A, Temple, A C, Allison
openaire +2 more sources