Results 1 to 10 of about 26,236 (223)

C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study [PDF]

International Journal of Retina and Vitreous
Background Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as
Paula Basso Dias, Iara Messias-Reason, Germano Ramos Boff, Kenzo Hokazono, Renato Nisihara   +4 more
doaj   +2 more sources

Changes of complement fragment C3a and its receptor in lung injury induced by silica nanoparticles

环境与职业医学, 2023
BackgroundSilica nanoparticles (SiNPs) enter the human body through respiratory tract, digestive tract, and skin, causing body damage. Lung is one of the main damaged organs.
Sifan ZHOU, Zhoujian WANG, Lei GAO, Yuansheng DUAN, Muyue CHEN, Jiaxiang ZHANG, Qixing ZHU   +6 more
doaj   +1 more source

Urinary C3 levels associated with sepsis and acute kidney injury-A pilot study.

PLoS ONE, 2021
Acute kidney injury (AKI) is an abrupt deterioration of renal function often caused by severe clinical disease such as sepsis, and patients require intensive care.
Sahra Pajenda, Florence Zawedde, Sebastian Kapps, Ludwig Wagner, Alice Schmidt, Wolfgang Winnicki, David O'Connell, Daniela Gerges   +7 more
doaj   +2 more sources

C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARα/CPT-1α Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension

Frontiers in Bioscience-Landmark, 2023
Background: Renin-dependent hypertension with tubulointerstitial injury remains a problem with high prevalence in the clinic. However, whether and how renin participates in tubulointerstitial injury remains incompletely understood.
Chongjian Wang, Zhiyu Wang, Jing Xu, Hongkun Ma, Kexin Jin, Tingting Xu, Xiaoxia Pan, Xiaobei Feng, Wen Zhang   +8 more
doaj   +1 more source

Cluster-Zone Leaf Removal and GA₃ Application at Early Flowering Reduce Bunch Compactness and Yield per Vine in Vitis vinifera cv. Pinot Gris

Horticulturae, 2022
Compact bunches have been often associated with higher susceptibility to Botrytis cinerea and therefore reduction in berry quality in grapevine. The objective of this study was to evaluate three management methods (early leaf removal, gibberellic acid ...
Mario Wegher, Michele Faralli, Massimo Bertamini   +2 more
doaj   +1 more source

A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]

PeerJ, 2019
Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki, Peter Pichler, Karl Mechtler, Richard Imre, Ines Steinmacher, Gürkan Sengölge, Daniela Knafl, Georg Beilhack, Ludwig Wagner   +8 more
doaj   +2 more sources

The association between serum complement C3a and severity in patients with community-acquired pneumonia

Frontiers in Immunology, 2023
BackgroundA few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure.
Zheng Xu, Zheng Xu, Zheng Xu, Xue-Feng Hou, Chun-Mei Feng, Ling Zheng, De-Xiang Xu, Hui Zhao, Hui Zhao, Lin Fu, Lin Fu, Lin Fu   +11 more
doaj   +1 more source

Complement C3a Enhances the Phagocytic Activity of B Cells Through C3aR in a Fish

Frontiers in Immunology, 2022
The complement system is an important part of the immune system of teleost fish. Besides, teleost B cells possess both phagocytic activity and adaptive humoral immune function, unlike mammalian B1 cells with phagocytic activity and B2 cells specific to ...
Zi-You Ma, Zi-You Ma, Zi-You Ma, Zi-You Ma, Jia-Xin Liang, Wen-Shuo Li, Yuan Sun, Chang-Song Wu, Chang-Song Wu, Chang-Song Wu, Ya-Zhen Hu, Ya-Zhen Hu, Ya-Zhen Hu, Jun Li, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Xu-Jie Zhang, Xu-Jie Zhang, Xu-Jie Zhang   +19 more
doaj   +1 more source

The Complement C3a and C3a Receptor Pathway in Kidney Diseases

Frontiers in Immunology, 2020
The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role.
Shuang Gao, Shuang Gao, Shuang Gao, Shuang Gao, Zhao Cui, Zhao Cui, Zhao Cui, Zhao Cui, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao   +12 more
doaj   +1 more source

Complement 3a and Complement 5a as Biochemical Markers in Diabetic Nephropathy [PDF]

International Journal of Medical Arts
Background: Diabetes mellitus [DM] is growing into a global epidemic and diabetic nephropathy [DN] is one of its most feared complications. Inflammation is an important mechanism in the pathogenesis of DN and many studies have pointed to anaphylatoxins ...
Safwat Ahmed, Alsayed Alsayed, Mohammed Aref, Ahmad Alkot   +3 more
doaj   +1 more source