Results 31 to 40 of about 24,276 (249)
C3aR plays both sides in regulating resistance to bacterial infections.
PLoS Pathogens, 2022 Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection.
Jesse A Corcoran, Brooke A Napier
doaj +2 more sources
Species-specific differences in regulation of macrophage inflammation by the C3a–C3a receptor axis [PDF]
Innate Immunity, 2018 Complement is an important arm of the innate immune system. Recent studies have shown that products of complement pathway activation can interact directly with other innate immune signaling molecules, including TLRs and inflammasome family members, during some infectious and chronic inflammatory disorders.
Ray, Tathagat Dutta +5 more
openaire +2 more sources
Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α
Journal of Neuroinflammation, 2022 Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Approximately one-third of MB patients remain incurable. Understanding the molecular mechanism of MB tumorigenesis is, therefore, critical for developing specific and ...
Biao Gong +9 more
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Sulfation of Tyrosine 174 in the Human C3a Receptor Is Essential for Binding of C3a Anaphylatoxin [PDF]
Journal of Biological Chemistry, 2003 The complement anaphylatoxin C3a and its cellular seven-transmembrane segment receptor, C3aR, are implicated in a variety of pathological inflammatory processes. C3aR is a G-protein-coupled receptor with an exceptionally large second extracellular loop of 172 amino acids. Previously reported deletion studies have shown that at least part of this region
Jinming, Gao +5 more
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HepG2/C3A cell metabolism. [PDF]
, 2013 (a) Glucose consumption for 1 million HepG2/C3A cells during 24 h after 3 days, 8 days and 10 days of culture in different bead compositions. (b) Albumin production during 24 h for 1 million HepG2 C3A cells entrapped in different bead compositions after ...
Stephanie H. Capone (407321) +7 more
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Virulence, 2019 The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Marcel Muenstermann +6 more
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Kilogram scale synthesis of C3A polymorphs and their hydration reactions
Cement, 2023 Studies on the properties of pure C3A phases are often limited to methods requiring small sample amounts due to the lack of a convenient laboratory synthesis yielding sample amounts exceeding 100 g. Here, we report a simple and large scale lab method for
Daniel Axthammer +3 more
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Regionally variable pulmonary artery responses to C3a [PDF]
, 1988 Products of the complement (C) cascade may have direct effects on pulmonary vascular tissue and contribute to pulmonary vasoconstriction in states of C activation.
T. W. Chick +6 more
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Complement activation contributes to perioperative neurocognitive disorders in mice
Journal of Neuroinflammation, 2018 Background The complement system plays an important role in many neurological disorders. Complement modulation, including C3/C3a receptor signaling, shows promising therapeutic effects on cognition and neurodegeneration.
Chao Xiong +5 more
doaj +1 more source
Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a [PDF]
, 2017 Complement C3a is an important protein in innate and adaptive immunity, but its specific roles in vivo remain uncertain because C3a degrades rapidly to form the C3a-desArg protein, which does not bind to the C3a receptor and is indistinguishable from C3a
Fairlie, David P. +35 more
core +1 more source