Results 51 to 60 of about 24,276 (249)

Complement inhibition promotes endogenous neurogenesis and sustained anti-inflammatory neuroprotection following reperfused stroke. [PDF]

PLoS ONE, 2012
The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent
Andrew F Ducruet, Brad E Zacharia, Sergey A Sosunov, Paul R Gigante, Mason L Yeh, Justin W Gorski, Marc L Otten, Richard Y Hwang, Peter A DeRosa, Zachary L Hickman, Paulina Sergot, E Sander Connolly   +11 more
doaj   +1 more source

Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activity [PDF]

, 2020
Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157.
Hamidon, Johan K, Fairlie, David P., Halili, Maria A., Reid, Robert C, Reid, Robert C., Iyer, Abishek, Lim, Junxian, Rowley, Jessica A, Rowley, Jessica A., Halili, Maria A, Lohman, Rink-Jan, Durek, Thomas, Poon, Eunice K. Y., Wu, Kai-Chen, Hamidon, Johan K., Fairlie, David P, Poon, Eunice KY, Yau, Mei-Kwan   +17 more
core   +1 more source

Synergistic Effects of Tricalcium Aluminate and Gypsum on Performance of Oil Well Cement Slurries

Zuanjingye yu wanjingye
To better control the quality of oil well cement, class G cement clinkers with different contents of tricalcium aluminate (C3A) were mixed with different kinds of gypsums, and study was conducted on the synergistic effects of C3A and gypsum on the ...
Dan DAI, Yixin WANG, Yiwei ZOU, Chao SUN, Ying MA, Xinjun SONG   +5 more
doaj   +1 more source

Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma

Cancer Biology & Medicine, 2021
Objective: Myeloma bone disease (MBD) is the most common complication of multiple myeloma (MM). Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the severity of bone disease.
Fengjuan Jiang, Hui Liu, Fengping Peng, Zhaoyun Liu, Kai Ding, Jia Song, Lijuan Li, Jin Chen, Qing Shao, Siyang Yan, Kim De Veirman, Karin Vanderkerken, Rong Fu   +12 more
doaj   +1 more source

Human monocyte-derived dendritic cells are chemoattracted to C3a after up-regulation of the C3a receptor with interferons [PDF]

, 2004
The anaphylatoxin C3a is an important inflammatory mediator in the innate and adaptive immune systems. Recent reports in various animal models have fostered the role of C3a in mediating allergic reactions such as pulmonary allergies.
Werfel, T., Kapp, Alexander, Miriam Wittmann, Gutzmer, Ralf, Alexander Kapp, Carola Diesel, Margarete Lisewski, Jorg Zwirner, Thomas Werfel, Lisewski, M., Mommert, S., Diesel, C., Zwirner, Joerg, Wittmann, M., Susanne Mommert, Ralf Gutzmer   +15 more
core   +1 more source

Vibrational Signals for Mating Disruption Do Not Negatively Affect Grapevine Growth and Production

Australian Journal of Grape and Wine Research
Vibrational mating disruption (VMD) is a promising strategy to control Scaphoideus titanus populations in vineyards, and it is based on the prolonged application of a species-specific disturbance vibrational signal (DVS) on grapevines.
Stefano Galvagni, Michele Perazzolli, Mauro Varner, Valerio Mazzoni, Gianfranco Anfora, Michele Faralli, Rachele Nieri   +6 more
doaj   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

ELISA of complement C3a in bronchoalveolar lavage fluid [PDF]

, 1992
Activated complement factors within the lung may induce several local biological effects. In order to investigate local complement activation we have developed non-competitive two-site ELISAs of C3a and total C3 in bronchoalveolar lavage fluid (BALF ...
Theo A. Out, van de Graaf, E. A., Jan-Karel M. Eeftinck Schattenkerk, Bakker, M. M., Alberts, C., Ed A. van de Graaf, Melan M. Bakker, Out, T. A., Jansen, H. M., Eeftinck Schattenkerk, J. K., Henk M. Jansen, Chris Alberts   +11 more
core   +1 more source

The Human Mast Cell Line HMC‐1 Binds and Responds to C3a but not C3a(desArg) [PDF]

Scandinavian Journal of Immunology, 1998
Controversial results have been published in the past regarding the functional reactivity of different cell types to the anaphylatoxin C3a and its degradation product C3a(desArg). To understand better the effects of C3a and C3a(desArg) on human mast cells, the authors performed binding experiments and calcium mobilization studies on the human mast cell
J, Zwirner, O, Götze, A, Sieber, A, Kapp, G, Begemann, T, Zuberbier, T, Werfel   +6 more
openaire   +2 more sources