Results 61 to 70 of about 24,276 (249)
Advanced Science, EarlyView.A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li +13 more
wiley +1 more source
Advanced Science, EarlyView.A self‐powered phase‐encoding sensing paradigm enables direct motion‐to‐time information conversion, providing a compact and autonomous strategy for high resolution angular displacement measurement. ABSTRACT In modern manufacturing and engineering, angular displacement sensors are crucial for motion control and feedback systems in Electromechanical ...
Shuxian Wang +3 more
wiley +1 more source
Complement peptide C3a promotes astrocyte survival in response to ischemia [PDF]
, 2016 Astrocytes are the most numerous cells in the central nervous system with a range of homeostatic and regulatory functions. Under normal conditions as well as after ischemia, astrocytes promote neuronal survival.
Shinjyo, Noriko, +3 more
core +1 more source
Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor [PDF]
Bioconjugate Chemistry, 2017 Measuring ligand affinity for a G protein-coupled receptor is often a crucial step in drug discovery. It has been traditionally determined by binding putative new ligands in competition with native ligand labeled with a radioisotope of finite lifetime.
Aline Dantas de Araujo +6 more
openaire +5 more sources
Mediators of Inflammation, 2020 The purpose of the current study was to explore the effect of autologous adipose tissue on cartilage responses to lipopolysaccharide (LPS). We hypothesized that LPS elicits an inflammatory response in cartilage, and that response is augmented in the ...
Wendy Pearson +4 more
doaj +1 more source
Efficient chemical synthesis of human complement protein C3a [PDF]
, 2013 We report the total chemical synthesis of human C3a by one-pot native chemical ligation of three unprotected peptide segments, followed by efficient in vitro folding that yielded the anaphylatoxin C3a in high yield and excellent purity. Synthetic C3a was
Lewis, Richard J. +7 more
core +1 more source
Synthetic peptides as antagonists of the anaphylatoxin C3a [PDF]
European Journal of Biochemistry, 1992 Peptide compounds resembling the receptor‐binding C‐terminal domain of the anaphylatoxic peptide C3a were synthesized to examine two kinds of C3a antagonism: (a) specific desensitization of C3a‐sensitive cells and (b) competitive binding to the C3a receptor.
T, Kretzschmar +7 more
openaire +2 more sources
Preservation of antimicrobial properties of complement peptide C3a - from invertebrates to humans. [PDF]
, 2007 The human anaphylatoxin peptide C3a, generated during complement activation, exerts antimicrobial effects. Phylogenetic analysis, sequence analyses, and structural modeling studies paired with antimicrobial assays of peptides from known C3a sequences ...
Walse, Bjorn +10 more
core +3 more sources
Navigating adverse immunostimulation: A practical guide for clinical researchers
British Journal of Clinical Pharmacology, EarlyView.Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort +3 more
wiley +1 more source
Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor [PDF]
, 2016 Human anaphylatoxin C3a, formed through cleavage of complement protein C3, is a potent effector of innate immunity via activation of its G protein coupled receptor, human C3aR.
Conor C. G. Scully (1724716) +6 more
core +1 more source