Results 61 to 70 of about 26,236 (223)

Hyperbranched poly‐L‐lysine surface‐engineered bioprosthetic heart valves with anti‐calcification, anti‐infection, and durability

BMEMat, EarlyView.
The challenges of bioprosthetic heart valves (BHV) with respect to calcification, infection, and poor durability are tackled by surface engineering of hyperbranched poly‐L‐lysine (HBPL), providing a translational solution to improve long‐term valve performance.
Pai Peng, Dongchao Qiu, Yongyuan Kang, Qiaoxuan Wang, Xuelong Wang, Boyana Parvanova, Miroslav Karabaliev, Changyou Gao   +7 more
wiley   +1 more source

Supplementary Figure 8 from An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype

C3a/C3aR pathway played an important role in the positive regulation of TIM-3 expression by NFAT1.
Yaochuan Zhang (18099403), Sheng Han (18099421), Yifu Song (18099406), Mengwu Shi (18099412), Dongxia Tao (18099418), Xiaoliang Wang (18099409), Yibin Lin (18099415)   +6 more
core   +1 more source

Influence of quartz surfaces on the reaction C3A + CaSO4.2H2O + water [PDF]

, 1977
Quartz surfaces counteract the retarding action of SO42- on the hydration of C3A, by presenting additional sites for ettringite crystallization. Strong retardation requires the presence of ettringite near the C3A, influencing the local concentrations ...
Holten, C.L.M., Stein, H.N., Stein, HN, Holten, CLM   +3 more
core   +2 more sources

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia

, 2016
Ischaemic stroke induces endogenous repair processes that include proliferation and differentiation of neural stem cells and extensive rewiring of the remaining neural connections, yet about 50% of stroke survivors live with severe long-term disability ...
Morán, Javier, Tulen Pekny, Barnum, Scott R, Pascoe, Michaela C,, Atkins, Alison L, Scott R. Barnum, Stokowska, Anna,, Michaela C. Pascoe, Atkins, Alison L,, Pascoe, Michaela, Stokowska, Anna, Barnum, Scott R,, Nilsson, Jonas A,, Alison L. Atkins, Dragunow, Mike,, Javier Morán, Linda Bulmer, Pekna, Marcela, Nilsson, Jonas A, Bulmer, Linda,, Wetsel, Rick A,, Wetsel, Rick A, Dragunow, Mike, Pascoe, Michaela C.,, Pekny, Tulen, Bulmer, Linda, Pekna, Marcela,, Pekny, Tulen,, Jonas A. Nilsson, Morán, Javier,, Anna Stokowska, Marcela Pekna, Mike Dragunow, Rick A. Wetsel   +33 more
core   +1 more source

Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium

Frontiers in Immunology, 2017
PurposeThe retinal pigment epithelium (RPE) is a main target for complement activation in age-related macular degeneration (AMD). The anaphylatoxins C3a and C5a have been thought to mostly play a role as chemoattractants for macrophages and immune cells;
Catharina Busch, Catharina Busch, Balasubramaniam Annamalai, Khava Abdusalamova, Nadine Reichhart, Christian Huber, Christian Huber, Yuchen Lin, Emeraldo A. H. Jo, Peter F. Zipfel, Christine Skerka, Gerhild Wildner, Maria Diedrichs-Möhring, Bärbel Rohrer, Bärbel Rohrer, Olaf Strauß   +15 more
doaj   +1 more source

Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity. [PDF]

PLoS ONE, 2017
In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, inflammation and tissue destruction. The complement system is a major mediator of inflammation for many diseases with the effectors C5a and C3a often playing important
Pamela S Hair, Laura A Sass, Turaj Vazifedan, Tushar A Shah, Neel K Krishna, Kenji M Cunnion   +5 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Quantitative analysis of the aluminate interactions in model and real cement slag pastes at an early age

Case Studies in Construction Materials
The present research investigated the hydration characteristics of model (C3S-C3A-gypsum-blast furnace slag) and real cement slag pastes at an early age, and emphasis was laid on the interaction of gypsum, aluminate phases dissolved from both C3A and ...
Yu Zhang, Chaoyu Liu, Luiz Miranda de Lima Junior, Chen Liu   +3 more
doaj   +1 more source

C3a receptor antagonist ameliorates inflammatory and fibrotic signals in type 2 diabetic nephropathy by suppressing the activation of TGF-β/smad3 and IKBα pathway.

PLoS ONE, 2014
ObjectiveDiabetic nephropathy (DN) is a serious complication for patients with diabetes mellitus (DM). Emerging evidence suggests that complement C3a is involved in the progression of DN.
Ling Li, Qinghua Yin, Xi Tang, Lin Bai, Jie Zhang, Shenju Gou, Hongping Zhu, Jingqiu Cheng, Ping Fu, Fang Liu   +9 more
doaj   +1 more source