Results 71 to 80 of about 56,153 (264)
Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu +6 more
wiley +1 more source
Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs [PDF]
, 2012 Hepatitis E virus (HEV) is an important but extremely understudied human pathogen. Genotypes 1 and 2 are restricted to humans, whereas genotypes 3 and 4 are zoonotic, infecting both humans and pigs.
Alicia R. Feagins +15 more
core +1 more source
Synthetic peptides as antagonists of the anaphylatoxin C3a [PDF]
European Journal of Biochemistry, 1992 Peptide compounds resembling the receptor‐binding C‐terminal domain of the anaphylatoxic peptide C3a were synthesized to examine two kinds of C3a antagonism: (a) specific desensitization of C3a‐sensitive cells and (b) competitive binding to the C3a receptor.
T, Kretzschmar +7 more
openaire +2 more sources
Porcine kidney xenotransplantation: From primate models to clinical reality
Animal Models and Experimental Medicine, EarlyView.In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo +3 more
wiley +1 more source
The Journal of Clinical Investigation, 2023 Despite advances in acute care, ischemic stroke remains a major cause of long-term disability. Approaches targeting both neuronal and glial responses are needed to enhance recovery and improve long-term outcome.
Anna Stokowska +18 more
doaj +1 more source
Journal of Materials Research and Technology, 2023 The role of ion diffusion in the heat flow and chemical shrinkage of tricalcium aluminate (C3A) hydration was investigated using the proposed multi-ionic reactive transport model for C3A hydration.
Yang Liu +5 more
doaj +1 more source
Three-Dimensional Solvable Artin Representations Ramified at One Prime [PDF]
, 2012 We classify the possibilities for the fixed field of the kernel of an irreducible three-dimensional Artin representation of $\Q$ with solvable image ramified at one prime by using the classification of the finite irreducible subgroups of $\PGL_3(\C ...
Leshin, Jonah
core +2 more sources
Agronomy, 2023 Targeted pruning techniques may have the potential to shift phenological progression in grapevines. These approaches can be useful to escape late frost (after budburst) and to delay ripening, maintaining yield and berry quality under specific ...
Massimo Bertamini, Michele Faralli
doaj +1 more source
Renormalization aspects of N=1 Super Yang-Mills theory in the Wess-Zumino gauge [PDF]
, 2014 The renormalization of N=1 Super Yang-Mills theory is analysed in the Wess-Zumino gauge, employing the Landau condition. An all orders proof of the renormalizability of the theory is given by means of the Algebraic Renormalization procedure.
Capri, M. A. L. +6 more
core +3 more sources
Navigating adverse immunostimulation: A practical guide for clinical researchers
British Journal of Clinical Pharmacology, EarlyView.Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort +3 more
wiley +1 more source