Results 71 to 80 of about 24,276 (249)

Impact of using yeast derivatives on the development of atypical aging in wines

open access: yesOENO One
Yeast derivatives (YDs) are commercial products obtained from yeast colonies grown in bioreactors then inactivated and dried. They are employed in winemaking to supply nitrogen (N), enhance yeast growth and remove unwanted compounds.
Simone Delaiti   +6 more
doaj   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort   +8 more
wiley   +1 more source

Trends in Ocean S‐Isotopes May Be Influenced by Major LIP Events

open access: yesGeophysical Monograph Series, Page 341-376., 2021

Exploring the links between Large Igneous Provinces and dramatic environmental impact

An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Ross. R. Large   +5 more
wiley  

+1 more source

Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity

open access: yesThe Journal of Clinical Investigation, 2023
Despite advances in acute care, ischemic stroke remains a major cause of long-term disability. Approaches targeting both neuronal and glial responses are needed to enhance recovery and improve long-term outcome.
Anna Stokowska   +18 more
doaj   +1 more source

Role of ionic diffusion in heat flow and chemical shrinkage of tricalcium aluminate hydration subjected to thermo-chemo-electrical coupled fields

open access: yesJournal of Materials Research and Technology, 2023
The role of ion diffusion in the heat flow and chemical shrinkage of tricalcium aluminate (C3A) hydration was investigated using the proposed multi-ionic reactive transport model for C3A hydration.
Yang Liu   +5 more
doaj   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

open access: yesBMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang   +13 more
wiley   +1 more source

Hyperbranched poly‐L‐lysine surface‐engineered bioprosthetic heart valves with anti‐calcification, anti‐infection, and durability

open access: yesBMEMat, EarlyView.
The challenges of bioprosthetic heart valves (BHV) with respect to calcification, infection, and poor durability are tackled by surface engineering of hyperbranched poly‐L‐lysine (HBPL), providing a translational solution to improve long‐term valve performance.
Pai Peng   +7 more
wiley   +1 more source

Influence of quartz surfaces on the reaction C3A + CaSO4.2H2O + water [PDF]

open access: yes, 1977
Quartz surfaces counteract the retarding action of SO42- on the hydration of C3A, by presenting additional sites for ettringite crystallization. Strong retardation requires the presence of ettringite near the C3A, influencing the local concentrations ...
Holten, C.L.M.   +3 more
core   +1 more source

Role of the Second Extracellular Loop of Human C3a Receptor in Agonist Binding and Receptor Function [PDF]

open access: yes, 1999
Producción CientíficaThe C3a anaphylatoxin receptor (C3aR) is a G protein-coupled receptor with an unusually large second extra-cellular loop (e2 loop,;172 amino acids).
Meiying Wang   +11 more
core   +3 more sources

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries   +8 more
wiley   +1 more source

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