Results 71 to 80 of about 26,236 (223)

Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease

Scientific Reports, 2021
We evaluated changes in the complement system resulting from anti-vascular endothelial growth factor (VEGF) in eyes with age-related choroidal neovascularization (CNV) including neovascular age-related macular degeneration, pachychoroid neovasculopathy ...
Keiichiro Tanaka, Yasuharu Oguchi, Tomoko Omori, Yumi Ishida, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu   +13 more
doaj   +1 more source

Human monocyte-derived dendritic cells are chemoattracted to C3a after up-regulation of the C3a receptor with interferons

, 2004
The anaphylatoxin C3a is an important inflammatory mediator in the innate and adaptive immune systems. Recent reports in various animal models have fostered the role of C3a in mediating allergic reactions such as pulmonary allergies.
Werfel, T., Kapp, Alexander, Miriam Wittmann, Gutzmer, Ralf, Alexander Kapp, Carola Diesel, Margarete Lisewski, Jorg Zwirner, Thomas Werfel, Lisewski, M., Mommert, S., Diesel, C., Zwirner, Joerg, Wittmann, M., Susanne Mommert, Ralf Gutzmer   +15 more
core   +1 more source

Influence of Drain and Operational Parameters on Backwash Cleaning Efficiency in a Commercial Sand Filter Model

Irrigation and Drainage, EarlyView.
ABSTRACT Some studies have demonstrated the influence of the drainage system design on the hydraulic behaviour and on the expansion of the filter bed during the backwashing process, with a presumed effect on removal efficiency. The objective was to evaluate the influence of the drainage system design of a commercial sand filter model, the operating ...
Mádilo Lages Vieira Passos, Fábio Ponciano de Deus, Evelise Roman Corbalan Góis Freire, Michael Silveira Thebaldi, Victor Buono da Silva Baptista   +4 more
wiley   +1 more source

Quantitative determination of tricalcicum aluminate in portland cement by X-ray diffraction

Materiales de Construccion, 1989
Tricalcium aluminate (C3A) is one of the constitutive phase of the cement-clinker. Its concentration influences the cement behaviour in sulphate aggressive soils. Therefore its quantification is very convenient and International standards fix its content
José Luis Sagrera Moreno
doaj   +1 more source

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

Journal of Experimental & Clinical Cancer Research, 2020
Background Mounting evidence suggests that complement components promote tumor progression via modulating immune suppression, angiogenesis, or tumor cell proliferation.
Chi Shu, Haoran Zha, Haixia Long, Xinxin Wang, Fei Yang, Jianbao Gao, Chunyan Hu, Li Zhou, Bo Guo, Bo Zhu   +9 more
doaj   +1 more source

Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activity

, 2020
Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157.
Hamidon, Johan K, Fairlie, David P., Halili, Maria A., Reid, Robert C, Reid, Robert C., Iyer, Abishek, Lim, Junxian, Rowley, Jessica A, Rowley, Jessica A., Halili, Maria A, Lohman, Rink-Jan, Durek, Thomas, Poon, Eunice K. Y., Wu, Kai-Chen, Hamidon, Johan K., Fairlie, David P, Poon, Eunice KY, Yau, Mei-Kwan   +17 more
core   +1 more source

Statistical Downscaling of Daily Temperature and Precipitation From Regional Climate Models in Complex Mountain Terrain

International Journal of Climatology, EarlyView.
The study provides insights for post‐processing climate model output in complex terrain, useful for climate change impact models. We compared different bias adjustment and downscaling techniques from quantile delta mapping to simple lapse rates. We developed a new spatial downscaling method based on principal components analysis, which showed superior ...
Michael Matiu, Anna Napoli, Alberto Bellin, Dino Zardi, Bruno Majone   +4 more
wiley   +1 more source

Complement C3a promotes the formation of osteoclasts by inhibiting Sirt1 to activate the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma

Journal of Translational Medicine
Background Myeloma bone disease (MBD) is the most common complication of multiple myeloma (MM). Our previous study showed that the complement C3a activates osteoclasts to participate in the pathogenesis of MBD; however, its mechanism of action is diverse
Fengjuan Jiang, Yunhe Zhang, Fengping Peng, Hui Liu, Kai Ding, Panpan Cao, Xiaohan Liu, Lijuan Li, Zhaoyun Liu, Rong Fu   +9 more
doaj   +1 more source

Zinc‐stabilized stannous fluoride modulates the periodontal microbiome, reducing Fusobacteria, key Gram‐negative species, and overall inflammation within an experimental gingivitis clinical trial

Journal of Periodontology, EarlyView.
Abstract Background This study aimed to evaluate the effects of a dentifrice containing stannous fluoride stabilized with zinc phosphate on subgingival microbiome composition and clinical inflammation during experimental gingivitis, compared with a sodium fluoride control. Methods This investigation was conducted as a secondary analysis of a randomized,
Kristopher A. Kerns, Allison A. Naumann, Lay Y. Soon, Erik L. Hendrickson, Abdelahhad Barbour, Dandan Chen, Harsh M. Trivedi, Michael Glogauer, Jeffrey S. McLean   +8 more
wiley   +1 more source

Microstructural evolution and degradation mechanisms of tricalcium silicate and tricalcium aluminate composite pastes under sulfate exposure

Case Studies in Construction Materials
Sulfate attack precipitates instability and degradation within calcium silicate (aluminate) hydrate (C-(A)-S-H) gel, the primary binding phase in cementitious materials.
Dengke Wang, Gaozhan Zhang, Qingjun Ding, Peng Yan, Yang Li   +4 more
doaj   +1 more source