Results 1 to 10 of about 3,979 (154)

Complement receptor C3aR marks heterogeneous tumor-associated macrophage states associated with improved survival in IDH-wildtype glioblastoma. [PDF]

Brain Pathol
C3aR expression in IDH‐wildtype glioblastoma is predominantly associated with the myeloid/macrophage compartment and heterogeneous macrophage states. C3aR‐high tumors are enriched among MGMT promoter‐methylated tumors and show improved overall survival, although the prognostic association requires independent validation.
Imara M, Bedoui Y, Pignolet T, Freppel S, Brochard C, Delattre A, Cappellen D, Bauchet L, Khettab M, Ah-Pine F.   +9 more
europepmc   +3 more sources

The C3-C3aR axis modulates trained immunity in alveolar macrophages. [PDF]

Elife
Complement protein C3 is crucial for immune responses in mucosal sites such as the lung, where it aids in microbe elimination, and enhances inflammation.
Earhart AP, Lopez AE, Hernandez JI, Nallapu A, Chavez D, Suthakaran S, Yang B, Hyun J, Aponte Alburquerque R, Starick M, Garnica L, Ozanturk AN, Maurya RK, Wu X, Haspel J, Lee JW, Hook J, Kulkarni HS.   +17 more
europepmc   +3 more sources

The Complex Role of the Complement C3a Receptor (C3aR) in Cerebral Injury and Recovery Following Ischemic Stroke. [PDF]

Cells
The Complement C3a Receptor (C3aR) plays a multifaceted role along the varying temporal phases of brain injury following cerebral ischemia. C3aR is a G-protein-coupled receptor (GPCR) that binds to its ligand, C3a an anaphylatoxin generated during ...
Akhter N, Lambay A, Almotairi R, Hamadi A, Bhatia K, Ahmad S, Ducruet AF.   +6 more
europepmc   +3 more sources

Pharmacological targeting of C3aR modulates mesangial matrix deposition in db/db mice. [PDF]

PeerJ
Complement activation significantly contributes to the progression of diabetic kidney disease (DKD). Recent studies have shown that renal levels of the complement component 3 (C3) and its receptor (C3aR) increase with disease progression.
Zheng J, Wu X, Weng M, Wan J, Zhang X.
europepmc   +3 more sources

Astrocyte-microglia interaction through C3/C3aR pathway modulates neuropathic pain in rats model of chronic constriction injury

Molecular Pain, 2022
Neuropathic pain (NP) is the cardinal symptom of neural injury, and its underlying molecular mechanism needs further investigation. Complements, especially complement 3 (C3), are involved in the pathophysiology of many neurological disorders, while the ...
Yuguang Huang, Lulu Ma, Huan Cui
exaly   +2 more sources

Intratumoral C3ar/C5ar1 Antagonists Imbedded in an In Situ Forming Implant Can Robustly Suppress Solid Tumors. [PDF]

Cells
Solid tumors typically expand in a “cold” immunosuppressive tumor microenvironment (TME) and resist killing by CAR T cells or conventional therapy.
Choi YA, Konrad R, Pohlmann ES, Abenojar E, Exner A, Medof ME.   +5 more
europepmc   +2 more sources

Molecular basis of diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptor C3aR. [PDF]

Nat Commun
The complement anaphylatoxin receptor, C3aR, is a prototypical G protein-coupled receptor (GPCR) that plays multi-faceted roles in immune regulation, pro-inflammatory responses, neuroimmune modulation, and host defense mechanisms against pathogens ...
Mishra S, Yadav MK, Dalal A, Ganguly M, Yadav R, Sawada K, Tiwari D, Roy N, Banerjee N, Fung JN, Marallag J, Cui CS, Li XX, Lee JD, Dsouza CA, Sarma P, Rawat G, Zhu H, Khant HA, Clark RJ, Sano FK, Banerjee R, Woodruff TM, Nureki O, Gati C, Shukla AK.   +25 more
europepmc   +2 more sources

Metabolic Reprogramming of Brain Microglia: Implications for Aging and Aging-Associated Neurodegenerative Diseases. [PDF]

Aging Cell
Microglia, the brain's resident macrophages, undergo metabolic reprogramming during aging, which impacts brain health and neurodegenerative disease risk. Understanding mechanisms of microglial metabolic regulation is key to the development of therapeutic strategies to promote homeostasis and mitigate harmful neuroinflammatory processes that contribute ...
Kang S, Goodridge HS.
europepmc   +2 more sources

Targeting C3aR/STAT3 signaling attenuates neuroinflammation and reverses neurological impairment in Neuromyelitis optica [PDF]

Fundam Res
Abundant evidence indicates that the interaction between astrocytes and microglia through the C3–C3a receptor (C3aR) pathway is a crucial contributor to the pathogenesis of neurodegenerative and autoimmune disorders, such as neuromyelitis optica (NMO ...
Xu L, Wang X, Xu H, Chen S, Jiang W, Li H, Afridi S, Wang Y, Luo W, Yang H, Tang C, Qiu W.   +11 more
europepmc   +2 more sources

Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections

Virulence, 2019
The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Andreas Klos, Kay O Johswich, Jörg Köhl   +2 more
exaly   +2 more sources