Results 41 to 50 of about 3,979 (154)

The complement receptor C3AR constitutes a novel therapeutic target in NPM1-mutated AML [Elektronisk resurs]

, 2023
Mutated Nucleophosmin 1 (NPM1) is the most common genetic alteration in acute myeloid leukemia (AML), found in approximately 30% of cases. Although mutations in this gene are considered favorable according to current risk stratification guidelines, a ...
Thorsson, Hanna,, Lilljebjörn, Henrik,, Sandén, Carl,, Lazarevic, Vladimir Lj,, Peña-Martínez, Pablo,, von Palffy, Sofia,, Juliusson, Gunnar,, Järås, Marcus,, Puente-Moncada, Noelia,, Henningsson, Rasmus,, Landberg, Niklas,, Blom, Anna M,, Rissler, Marianne,, Orsmark-Pietras, Christina,, Ågerstam, Helena,, King, Ben,, Rissler, Vendela,, Lund University., Fioretos, Thoas,   +18 more
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Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells. [PDF]

PLoS ONE, 2012
The anaphylatoxin C3a binds to the G protein coupled receptor (GPCR, C3aR) and activates divergent signaling pathways to induce degranulation and cytokine production in human mast cells. Adapter proteins such as the Na(+)/H(+) exchange regulatory factor (
Hariharan Subramanian, Kshitij Gupta, Hydar Ali   +2 more
doaj   +1 more source

Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice

, 2020
OBJECTIVE: Emerging evidence suggests that C3aR (C3a anaphylatoxin receptor) signaling has protective roles in various inflammatory-related diseases. However, its role in atherosclerosis has been unknown.
Li, Zong Fang, Liu, Enqi, Wei, Lin Lin, Chen, Daxin, Li, Ke, Ma, Ning, Wu, Kun Yi, Zhao, Shu Juan, Zhou, Wuding, Bai, Liang, Wang, Jia Xing, Diao, Teng Yue   +11 more
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Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity

The Journal of Clinical Investigation, 2023
Despite advances in acute care, ischemic stroke remains a major cause of long-term disability. Approaches targeting both neuronal and glial responses are needed to enhance recovery and improve long-term outcome.
Anna Stokowska, Markus Aswendt, Daniel Zucha, Stephanie Lohmann, Frederique Wieters, Javier Morán Suarez, Alison L. Atkins, YiXian Li, Maria Miteva, Julia Lewin, Dirk Wiedermann, Michael Diedenhofen, Åsa Torinsson Naluai, Pavel Abaffy, Lukas Valihrach, Mikael Kubista, Mathias Hoehn, Milos Pekny, Marcela Pekna   +18 more
doaj   +1 more source

Monitoring C3aR Expression Using a Floxed tdTomato-C3aR Reporter Knock-in Mouse

, 2017
C3a exerts multiple biologic functions through activation of its cognate C3a receptor. C3−/− and C3aR−/− mice have been instrumental in defining important roles of the C3a/C3aR axis in the regulation of acute and chronic inflammatory diseases, including ...
Christian M. Karsten, Anna Kordowski, Johann L. Berger, Anna V. Wiese, Konstantina Antoniou, Larissa Nogueira Almeida, Tillman Vollbrandt, Inken Schmudde, Daria Briukhovetska, Jing Sun, Peter König, Fanny Ender, Jörg Köhl, Yves Laumonnier, Torsten Schröder, Katharina M. Quell   +15 more
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C3aR signaling is essential for adipocyte differentiation.

, 2016
(A) Knockdown of C3aR inhibits adipocyte differentiation. C3H10T1/2 cells were infected with virus harboring two independent shRNAs against C3aR or scrambled shRNA (scr) and stable cells were selected with puromycin (2 μg/ml) for 2 weeks.
Ui Jeong Yun (3111426), Seo-Hyuk Chang (3111417), No-Joon Song (3111423), Dean Y. Li (46432), Kye Won Park (785952), Hironori Waki (200172), Peter Tontonoz (165319), Suji Kim (1807360), Ki-Moon Park (3111420), Byung-Hyun Jang (3111429)   +9 more
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Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway

Cell Reports, 2023
Summary: Complement activation is thought to underline the pathologic progression of obesity-related metabolic disorders; however, its role in adaptive thermogenesis has scarcely been explored.
Ling-Ran Kong, Xiao-Hui Chen, Qing Sun, Kai-Yuan Zhang, Lian Xu, Liliqiang Ding, Yan-Ping Zhou, Ze-Bei Zhang, Jing-Rong Lin, Ping-Jin Gao   +9 more
doaj   +1 more source

Characterization of phosphorylation sites in C3aR.

, 2013
(A) Schematic representation of the carboxyl-terminal domain of C3aR (WT) and mutants MT1–MT7 used for phosphorylation studies. (B) HEK293 cells transiently expressing HA-tagged C3aR or mutants were labeled with 32P and exposed to buffer or C3a (100 nM ...
Andreas Klos (71279), Hydar Ali (292814), Kshitij Gupta (292813), Hariharan Subramanian (292812)   +3 more
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C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

, 2013
Mammalian survival depends on metabolizing nutrients, storing energy, and combating infection. Complement activation in blood triggers energy-depleting immune responses to fight infections.
Fairlie, David P., Seow, Vernon, Brown, Lindsay, Reid, Robert C., Liu, Junxian, Iyer, Abishek, Suen, Jacky Y., Lim, Junxian   +7 more
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C3a/C3aR Affects the Propagation of Cryptosporidium parvum in the Ileum Tissues of Mice by Regulating the Gut Barrier, Cell Proliferation, and CD4⁺ T Cell Main Effectors

Animals, 2023
Cryptosporidium parvum is an important zoonotic protozoon that threatens the health of humans and animals, but the interaction mechanisms between C. parvum and hosts are poorly understood.
Xin Yang, Xuemei Wu, Shuang Huang, Qian Yao, Xi Chen, Junke Song, Yingying Fan, Guanghui Zhao   +7 more
doaj   +1 more source