Downregulation of complement C3 and C3aR expression in subcutaneous adipose tissue in obese women. [PDF]
PLoS ONE, 2014 The central component of the complement system, C3, is associated with obesity, metabolic syndrome and cardiovascular disease however the underlying reasons are unknown.
Abhishek Gupta +7 more
doaj +1 more source
C3a Receptor Signaling Inhibits Neurodegeneration Induced by Neonatal Hypoxic-Ischemic Brain Injury
Frontiers in Immunology, 2021 Hypoxic-ischemic neonatal encephalopathy due to perinatal asphyxia is the leading cause of brain injury in newborns. Clinical data suggest that brain inflammation induced by perinatal insults can persist for years.
Andrea Pozo-Rodrigálvarez +13 more
doaj +1 more source
Knockdown of C3aR alleviates age-related bone loss via activation of YAP1/β-catenin signaling [PDF]
Journal of Biological ChemistryShun Cui
exaly +2 more sources
The Journal of Clinical Investigation, 2023 Despite advances in acute care, ischemic stroke remains a major cause of long-term disability. Approaches targeting both neuronal and glial responses are needed to enhance recovery and improve long-term outcome.
Anna Stokowska +18 more
doaj +1 more source
Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells. [PDF]
PLoS ONE, 2012 The anaphylatoxin C3a binds to the G protein coupled receptor (GPCR, C3aR) and activates divergent signaling pathways to induce degranulation and cytokine production in human mast cells. Adapter proteins such as the Na(+)/H(+) exchange regulatory factor (
Hariharan Subramanian +2 more
doaj +1 more source
Journal of Innate Immunity, 2021 To study the molecular interplay between TLRs and complement representing ancient danger-sensing mechanisms, we examined the regulation of the C3a/anaphylatoxin C3a receptor (C3aR) axis in normal human epidermal keratinocytes (NHEKs) by treatment with ...
Susanne Mommert +5 more
doaj +1 more source
Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance. [PDF]
, 2020 Stromal-epithelial interactions dictate cancer progression and therapeutic response. Prostate cancer (PCa) cells were identified to secrete greater concentration of mitochondrial DNA (mtDNA) compared to noncancer epithelia.
Agarwal, Priyanka +11 more
core
Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10 [PDF]
, 2014 Aim: Human CXCR3, a seven-transmembrane segment (7TMS), is predominantly expressed in Th1-mediated responses. Interferon-γ-inducible protein 10 (IP-10) is an important ligand for CXCR3. Their interaction is pivotal for leukocyte migration and activation.
Fang, Fu-de +8 more
core +1 more source
TLQP-21 is a low potency partial C3aR activator on human primary macrophages
Frontiers in Immunology, 2023 TLQP-21 is a 21-amino acid neuropeptide derived from the VGF precursor protein. TLQP-21 is expressed in the nervous system and neuroendocrine glands, and demonstrates pleiotropic roles including regulating metabolism, nociception and microglial functions.
Xaria X. Li +4 more
doaj +1 more source
Pyridinium N-heteroarylaminides: synthesis of N-heteroaryltetramines based on 1,6-bis(phenoxy)hexane and 1,3-bis(phenoxymethyl)benzene [PDF]
, 2007 The synthesis of a set of new N-heteroaryltetramines is reported. A regioselective alkylation on the N-exo nitrogen of pyridinium N-(heteroaryl)aminide with the corresponding tetrabromo compounds, followed by a clean N–N bond reduction of the ...
Castillo Romero, Rafael +2 more
core +2 more sources