Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism [PDF]
Frontiers in Immunology, 2021 Complement component 3 fragment C3a is an anaphylatoxin involved in promoting cellular responses important in immune response and host defense. Its receptor (C3a receptor, C3aR) is distributed on the plasma membrane; however, lysosomal localization in ...
Masaaki Ishii +5 more
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The Complement C3a and C3a Receptor Pathway in Kidney Diseases [PDF]
Frontiers in Immunology, 2020 The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role.
Shuang Gao +12 more
doaj +3 more sources
C3a Receptor Signaling Inhibits Neurodegeneration Induced by Neonatal Hypoxic-Ischemic Brain Injury [PDF]
Frontiers in Immunology, 2021 Hypoxic-ischemic neonatal encephalopathy due to perinatal asphyxia is the leading cause of brain injury in newborns. Clinical data suggest that brain inflammation induced by perinatal insults can persist for years.
Andrea Pozo-Rodrigálvarez +13 more
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The Complex Role of the Complement C3a Receptor (C3aR) in Cerebral Injury and Recovery Following Ischemic Stroke [PDF]
CellsThe Complement C3a Receptor (C3aR) plays a multifaceted role along the varying temporal phases of brain injury following cerebral ischemia. C3aR is a G-protein-coupled receptor (GPCR) that binds to its ligand, C3a an anaphylatoxin generated during ...
Naseem Akhter +6 more
doaj +3 more sources
Deficiency of C3a receptor attenuates the development of diabetic nephropathy [PDF]
BMJ Open Diabetes Research & Care, 2019 Objective Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and end-stage renal disease. Emerging evidence suggests that complement activation is involved in the pathogenesis of DN.
Ming-hui Zhao +2 more
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SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling. [PDF]
Sci Rep, 2023 The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can interact with endothelial cells. However, no studies demonstrated the direct effect of the spike protein subunit 1 (S1) in inducing lung vascular damage and the ...
Perico L +8 more
europepmc +2 more sources
Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy. [PDF]
J Am Soc Nephrol, 2022 Significance Statement Membranous nephropathy (MN) is the leading cause of adult nephrotic syndrome, in which the complement system is highly activated.
Gao S, Cui Z, Zhao MH.
europepmc +2 more sources
Complement C3a receptor inactivation attenuates retinal degeneration induced by oxidative damage. [PDF]
Front Neurosci, 2022 Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. Evidence indicates that the activation of the complement system is associated with retinal degeneration.
Wang S, Du L, Yuan S, Peng GH.
europepmc +2 more sources
The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure. [PDF]
Nat Commun, 2022 Failure of the right ventricle plays a critical role in any type of heart failure. However, the mechanism remains unclear, and there is no specific therapy.
Ito S +34 more
europepmc +2 more sources
Targeting Complement C3a Receptor to Improve Outcome After Ischemic Brain Injury. [PDF]
Neurochem Res, 2021 Ischemic stroke is a major cause of disability. No efficient therapy is currently available, except for the removal of the occluding blood clot during the first hours after symptom onset.
Pekna M, Stokowska A, Pekny M.
europepmc +2 more sources