International Journal of Environmental SciencesCryptosporidium parvum and Entamoeba histolytica are significant protozoan parasites that adversely impact human health. The infection rate of these parasites among diabetic patients was recorded at 18.33%. However, the mechanisms underlying host-parasite interactions remain poorly understood.
Bafreen Mohamad Raza +2 more
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Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging. [PDF]
J Clin Invest, 2021 Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer's disease; however, their interrelatedness remains poorly understood. The complement pathway is a well-established regulator of innate immunity in the brain.
Propson NE +4 more
europepmc +2 more sources
Effect of the C3a-Receptor Antagonist SB 290157 on Anti-OVA Polyclonal Antibody–Induced Arthritis
Journal of Pharmacological Sciences, 2010 It was investigated whether the C3a-receptor antagonist (C3aRA) SB 290157 was involved in the suppression of anti-OVA pAb–induced arthritis because it is well known that anaphylatoxin C3a plays a crucial role in the development of an effective ...
Pilaiwanwadee Hutamekalin +6 more
doaj +3 more sources
Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor
Journal of Medicinal Chemistry, 2010 Human anaphylatoxin C3a, formed through cleavage of complement protein C3, is a potent effector of innate immunity via activation of its G protein coupled receptor, human C3aR. Previously reported short peptide ligands for this receptor either have low potency or lack receptor selectivity.
Conor C. G. Scully +6 more
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C3a receptor blockade protects podocytes from injury in diabetic nephropathy. [PDF]
JCI Insight, 2020 Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined.
Morigi M +10 more
europepmc +2 more sources
How complement activation via a C3a receptor pathway alters CD4+ T lymphocytes and mediates lung cancer progression?-future perspectives. [PDF]
J Thorac Dis, 2019 Magalhães Filho M +3 more
europepmc +2 more sources
Is the C3a receptor antagonist SB290157 a useful pharmacological tool? [PDF]
Br J Pharmacol, 2020 Lee JD, Taylor SM, Woodruff TM.
europepmc +2 more sources
Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice. [PDF]
J Neuroinflammation, 2020 The risk of glaucoma increases significantly with age and exposure to elevated intraocular pressure, two factors linked with neuroinflammation. The complement cascade is a complex immune process with many bioactive end-products, including mediators of ...
Harder JM +7 more
europepmc +2 more sources
C3a receptor antagonist therapy is protective with or without thrombolysis in murine thromboembolic stroke. [PDF]
Br J Pharmacol, 2020 Intravenous thrombolysis (IVT) after stroke enhances C3a generation, which may abrogate the benefits of reperfusion. The C3aR antagonist SB290157 is neuroprotective following transient but not permanent middle cerebral artery occlusion (MCAo).
Ahmad S +10 more
europepmc +2 more sources