Results 41 to 50 of about 3,935,620 (190)
Effect of the C3a-Receptor Antagonist SB 290157 on Anti-OVA Polyclonal Antibody–Induced Arthritis
Journal of Pharmacological Sciences, 2010 It was investigated whether the C3a-receptor antagonist (C3aRA) SB 290157 was involved in the suppression of anti-OVA pAb–induced arthritis because it is well known that anaphylatoxin C3a plays a crucial role in the development of an effective ...
Pilaiwanwadee Hutamekalin +6 more
doaj +3 more sources
C3aR plays both sides in regulating resistance to bacterial infections.
PLoS Pathogens, 2022 Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection.
Jesse A Corcoran, Brooke A Napier
doaj +2 more sources
Brain Research Bulletin, 2023 Human tauopathies, including Alzheimer's disease (AD), are a major class of neurodegenerative diseases characterized by intracellular deposition of pathological hyperphosphorylated forms of Tau protein.
Yi Yao +9 more
semanticscholar +1 more source
Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α
Journal of Neuroinflammation, 2022 Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Approximately one-third of MB patients remain incurable. Understanding the molecular mechanism of MB tumorigenesis is, therefore, critical for developing specific and ...
Biao Gong +9 more
doaj +1 more source
Complement inhibition promotes endogenous neurogenesis and sustained anti-inflammatory neuroprotection following reperfused stroke. [PDF]
PLoS ONE, 2012 The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent
Andrew F Ducruet +11 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: Renin-dependent hypertension with tubulointerstitial injury remains a problem with high prevalence in the clinic. However, whether and how renin participates in tubulointerstitial injury remains incompletely understood.
Chongjian Wang +8 more
doaj +1 more source
Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]
, 1994 To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, J. C. +16 more
core +2 more sources
Role of the second extracellular loop of human C3a receptor in agonist binding and receptor function [PDF]
, 2013 The C3a anaphylatoxin receptor (C3aR) is a G protein-coupled receptor with an unusually large second extracellular loop (e2 loop, ~172 amino acids).
Bayón, Yolanda
core +2 more sources
Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins
Frontiers in Immunology, 2021 Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West +8 more
doaj +1 more source
Genomic organization of the human C3a receptor [PDF]
European Journal of Immunology, 1998 The human C3a receptor (C3aR) mediates the activation of cells by the potent proinflammatory chemoattractant C3a, an anaphylatoxin, generated in the early phase of an inflammatory reaction by proteolytic cleavage of the complement component C3. To understand the molecular mechanisms that regulate C3aR gene expression, we initiated studies to determine ...
D, Paral +6 more
openaire +2 more sources