Results 51 to 60 of about 3,935,620 (190)

Shiga Toxin 2 Triggers C3a-Dependent Glomerular and Tubular Injury through Mitochondrial Dysfunction in Hemolytic Uremic Syndrome

Cells, 2022
Shiga toxin (Stx)-producing Escherichia coli is the predominant offending agent of post-diarrheal hemolytic uremic syndrome (HUS), a rare disorder of microvascular thrombosis and acute kidney injury possibly leading to long-term renal sequelae.
Simona Buelli, Monica Locatelli, Claudia Elisa Carminati, Daniela Corna, Domenico Cerullo, Barbara Imberti, Luca Perico, Maurizio Brigotti, Mauro Abbate, Carlamaria Zoja, Ariela Benigni, Giuseppe Remuzzi, Marina Morigi   +12 more
doaj   +1 more source

Chimeric Receptors of the Human C3a Receptor and C5a Receptor (CD88) [PDF]

Journal of Biological Chemistry, 1999
Chimeras were generated between the human anaphylatoxin C3a and C5a receptors (C3aR and C5aR, respectively) to define the structural requirements for ligand binding and discrimination. Chimeric receptors were generated by systematically exchanging between the two receptors four receptor modules (the N terminus, transmembrane regions 1 to 4, the second ...
T, Crass, R S, Ames, H M, Sarau, M A, Tornetta, J J, Foley, J, Köhl, A, Klos, W, Bautsch   +7 more
openaire   +2 more sources

Complement activation contributes to perioperative neurocognitive disorders in mice

Journal of Neuroinflammation, 2018
Background The complement system plays an important role in many neurological disorders. Complement modulation, including C3/C3a receptor signaling, shows promising therapeutic effects on cognition and neurodegeneration.
Chao Xiong, Jinhu Liu, Dandan Lin, Juxia Zhang, Niccolò Terrando, Anshi Wu   +5 more
doaj   +1 more source

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
doaj   +1 more source

C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

Journal of Translational Medicine, 2023
Background Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT).
Danyu You, Kun Nie, Xiaoting Wu, Mengjie Weng, Liyan Yang, Yi Chen, Jiong Cui, Jianxin Wan   +7 more
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Complement C3a Enhances the Phagocytic Activity of B Cells Through C3aR in a Fish

Frontiers in Immunology, 2022
The complement system is an important part of the immune system of teleost fish. Besides, teleost B cells possess both phagocytic activity and adaptive humoral immune function, unlike mammalian B1 cells with phagocytic activity and B2 cells specific to ...
Zi-You Ma, Zi-You Ma, Zi-You Ma, Zi-You Ma, Jia-Xin Liang, Wen-Shuo Li, Yuan Sun, Chang-Song Wu, Chang-Song Wu, Chang-Song Wu, Ya-Zhen Hu, Ya-Zhen Hu, Ya-Zhen Hu, Jun Li, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Xu-Jie Zhang, Xu-Jie Zhang, Xu-Jie Zhang   +19 more
doaj   +1 more source

Characterization of a C3a Receptor in Rainbow Trout and Xenopus : The First Identification of C3a Receptors in Nonmammalian Species [PDF]

The Journal of Immunology, 2005
Abstract Virtually nothing is known about the structure, function, and evolutionary origins of the C3aR in nonmammalian species. Because C3aR and C5aR are thought to have arisen from the same common ancestor, the recent characterization of a C5aR in teleost fish implied the presence of a C3aR in this animal group.
Hani, Boshra, Tiehui, Wang, Leif, Hove-Madsen, John, Hansen, Jun, Li, Anjun, Matlapudi, Christopher J, Secombes, Lluis, Tort, J Oriol, Sunyer   +8 more
openaire   +2 more sources

Sulfation of Tyrosine 174 in the Human C3a Receptor Is Essential for Binding of C3a Anaphylatoxin [PDF]

Journal of Biological Chemistry, 2003
The complement anaphylatoxin C3a and its cellular seven-transmembrane segment receptor, C3aR, are implicated in a variety of pathological inflammatory processes. C3aR is a G-protein-coupled receptor with an exceptionally large second extracellular loop of 172 amino acids. Previously reported deletion studies have shown that at least part of this region
Jinming, Gao, Hyeryun, Choe, Dalena, Bota, Paulette L, Wright, Craig, Gerard, Norma P, Gerard   +5 more
openaire   +2 more sources

Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer

Journal for ImmunoTherapy of Cancer, 2021
Background Resistance to therapy is a major problem in treating head and neck squamous cell carcinomas (HNSCC). Complement system inhibition has been shown to reduce tumor growth, metastasis, and therapeutic resistance in other tumor models, but has yet ...
Emily K Kleczko, Raphael A Nemenoff, Michael William Knitz   +2 more
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Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. [PDF]

PLoS ONE, 2011
The complement component C3a induces degranulation in human mast cells via the activation of cell surface G protein coupled receptors (GPCR; C3aR).
Arpana Vibhuti, Kshitij Gupta, Hariharan Subramanian, Qiang Guo, Hydar Ali   +4 more
doaj   +1 more source