Results 51 to 60 of about 2,660,664 (273)

Complement C3a Receptor Antagonist Alleviates Tau Pathology and Ameliorates Cognitive Deficits in P301S Mice.

Brain Research Bulletin, 2023
Human tauopathies, including Alzheimer's disease (AD), are a major class of neurodegenerative diseases characterized by intracellular deposition of pathological hyperphosphorylated forms of Tau protein.
Yi Yao, Yanmin Chang, Shaoming Li, Jiahui Zhu, Yuehua Wu, Xingjun Jiang, Lulu Li, Rui‐tian Liu, Rong Ma, Gang Li   +9 more
semanticscholar   +1 more source

C3a Receptor Inhibition Protects Brain Endothelial Cells Against Oxygen-glucose Deprivation/Reperfusion. [PDF]

Exp Neurobiol, 2019
The complement cascade is a central component of innate immunity which plays a critical role in brain inflammation. Complement C3a receptor (C3aR) is a key mediator of post-ischemic cerebral injury, and pharmacological antagonism of the C3a receptor is ...
Ahmad S, Kindelin A, Khan SA, Ahmed M, Hoda MN, Bhatia K, Ducruet AF.   +6 more
europepmc   +2 more sources

C3aR plays both sides in regulating resistance to bacterial infections.

PLoS Pathogens, 2022
Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection.
Jesse A Corcoran, Brooke A Napier
doaj   +2 more sources

Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α

Journal of Neuroinflammation, 2022
Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Approximately one-third of MB patients remain incurable. Understanding the molecular mechanism of MB tumorigenesis is, therefore, critical for developing specific and ...
Biao Gong, Duancheng Guo, Chaonan Zheng, Zhen Ma, Jie Zhang, Yanghui Qu, Xinhua Li, Gen Li, Li Zhang, Yuan Wang   +9 more
doaj   +1 more source

Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity

Journal of Medicinal Chemistry, 2020
Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157.
Jessica A. Rowley, Robert C. Reid, Eunice K. Y. Poon, Kai‐Chen Wu, Junxian Lim, Rink‐Jan Lohman, Johan K. Hamidon, Mei‐Kwan Yau, Maria A. Halili, Thomas Durek, Abishek Iyer, David P. Fairlie   +11 more
openalex   +3 more sources

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
doaj   +1 more source

A C3(H20) recycling pathway is a component of the intracellular complement system [PDF]

, 2017
An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores
Botto, Bu, Hrishikesh S. Kulkarni, John P. Atkinson, Liszewski, M. Kathryn Liszewski, Michelle Elvington, Nickells, Paula Bertram, Seya, Singer, Vĕtvicka   +11 more
core   +2 more sources

C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

Journal of Translational Medicine, 2023
Background Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT).
Danyu You, Kun Nie, Xiaoting Wu, Mengjie Weng, Liyan Yang, Yi Chen, Jiong Cui, Jianxin Wan   +7 more
doaj   +1 more source

Complement C3a Enhances the Phagocytic Activity of B Cells Through C3aR in a Fish

Frontiers in Immunology, 2022
The complement system is an important part of the immune system of teleost fish. Besides, teleost B cells possess both phagocytic activity and adaptive humoral immune function, unlike mammalian B1 cells with phagocytic activity and B2 cells specific to ...
Zi-You Ma, Zi-You Ma, Zi-You Ma, Zi-You Ma, Jia-Xin Liang, Wen-Shuo Li, Yuan Sun, Chang-Song Wu, Chang-Song Wu, Chang-Song Wu, Ya-Zhen Hu, Ya-Zhen Hu, Ya-Zhen Hu, Jun Li, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Xu-Jie Zhang, Xu-Jie Zhang, Xu-Jie Zhang   +19 more
doaj   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core   +1 more source