Results 71 to 80 of about 3,935,620 (190)

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

Journal of Experimental & Clinical Cancer Research, 2020
Background Mounting evidence suggests that complement components promote tumor progression via modulating immune suppression, angiogenesis, or tumor cell proliferation.
Chi Shu, Haoran Zha, Haixia Long, Xinxin Wang, Fei Yang, Jianbao Gao, Chunyan Hu, Li Zhou, Bo Guo, Bo Zhu   +9 more
doaj   +1 more source

Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones

FEBS Open Bio, 2022
Acute lung injury (ALI) occurs in patients with severe sepsis and has a mortality rate of 40%–60%. Severe sepsis promotes the release of histones from dying cells, which can induce platelet aggregation, activate coagulation and cause endothelial cell (EC)
Fumihiko Nagano, Tomohiro Mizuno, Masaki Imai, Kazuo Takahashi, Naotake Tsuboi, Shoichi Maruyama, Masashi Mizuno   +6 more
doaj   +1 more source

The Role of the C3a-C3aR Pathway in Diseases: Latest Research Advances

Mediators of Inflammation
C3a is a key active factor in the complement system, capable of participating in various physiological and pathological processes by binding to its C3a receptor (C3aR).
Xiangwei Bo, Mi Wang, Yang Liu, Yong Zhong   +3 more
doaj   +1 more source

Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells. [PDF]

PLoS ONE, 2012
The anaphylatoxin C3a binds to the G protein coupled receptor (GPCR, C3aR) and activates divergent signaling pathways to induce degranulation and cytokine production in human mast cells. Adapter proteins such as the Na(+)/H(+) exchange regulatory factor (
Hariharan Subramanian, Kshitij Gupta, Hydar Ali   +2 more
doaj   +1 more source

Complement C3a, CpG Oligos, and DNA/C3a Complex Stimulate IFN-α Production in a Receptor for Advanced Glycation End Product-Dependent Manner

, 2010
The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor implicated in a number of diseases including autoimmune diseases.
Benfang Helen Ruan, Xin Li, Jun Kuai, Rita M. Greco, Jill F. Wright, David G. Winkler, Janet E. Paulsen, Karl H. Nocka, Kristina M. Cunningham, Debra D. Pittman, Lih Ling Lin, Aaron R. Winkler, Lori J. Fitz, Xiang-Yang Tan   +13 more
core   +1 more source

Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia

, 2016
Ischaemic stroke induces endogenous repair processes that include proliferation and differentiation of neural stem cells and extensive rewiring of the remaining neural connections, yet about 50% of stroke survivors live with severe long-term disability ...
Morán, Javier, Tulen Pekny, Barnum, Scott R, Pascoe, Michaela C,, Atkins, Alison L, Scott R. Barnum, Stokowska, Anna,, Michaela C. Pascoe, Atkins, Alison L,, Pascoe, Michaela, Stokowska, Anna, Barnum, Scott R,, Nilsson, Jonas A,, Alison L. Atkins, Dragunow, Mike,, Javier Morán, Linda Bulmer, Pekna, Marcela, Nilsson, Jonas A, Bulmer, Linda,, Wetsel, Rick A,, Wetsel, Rick A, Dragunow, Mike, Pascoe, Michaela C.,, Pekny, Tulen, Bulmer, Linda, Pekna, Marcela,, Pekny, Tulen,, Jonas A. Nilsson, Morán, Javier,, Anna Stokowska, Marcela Pekna, Mike Dragunow, Rick A. Wetsel   +33 more
core   +1 more source

Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation

BMC Biology, 2023
Background Immature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool in reproductive medicine to obtain mature oocytes. Unfortunately, the efficiency of IVM is not satisfactory. To circumvent
Ye Yang, Chun Zhao, Beili Chen, Xiaoning Yu, Yuxi Zhou, Danyu Ni, Xiaolan Zhang, Junqiang Zhang, Xiufeng Ling, Zhiguo Zhang, Ran Huo   +10 more
doaj   +1 more source

The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein

, 2003
The orphan receptor C5L2 has recently been described as a high affinity binding protein for complement fragments C5a and C3a that, unlike the previously described C5a receptor (CD88), couples only weakly to Gi-like G proteins (Cain, S. A., and Monk, P. N.
Cianflone, Katherine, Monk, Peter N., Maslowska, Magdalena, Sniderman, Allan D., Kalant, David, Allan D Sniderman, Katherine Cianflone, Peter N. Monk, Stuart A. Cain, David Kalant, Cain, Stuart A.; id_orcid, Magdalena Maslowska   +11 more
core   +1 more source

Complement and the alternative pathway play an important role in LPS/D-GalN-induced fulminant hepatic failure. [PDF]

PLoS ONE, 2011
Fulminant hepatic failure (FHF) is a clinically severe type of liver injury with an extremely high mortality rate. Although the pathological mechanisms of FHF are not well understood, evidence suggests that the complement system is involved in the ...
Shihui Sun, Yan Guo, Guangyu Zhao, Xiaojun Zhou, Junfeng Li, Jingya Hu, Hong Yu, Yu Chen, Hongbin Song, Fei Qiao, Guilian Xu, Fei Yang, Yuzhang Wu, Stephen Tomlinson, Zhongping Duan, Yusen Zhou   +15 more
doaj   +1 more source

Inflammatory kidney injury in trichloroethylene hypersensitivity syndrome mice: Possible role of C3a receptor in the accumulation of Th17 phenotype.

Ecotoxicology and Environmental Safety, 2019
Trichloroethylene (TCE) is a common organic solvent which can cause TCE hypersensitivity syndrome (THS) in exposure workers. THS is an adverse skin disorder with severe inflammatory kidney damage.
Feng Wang, Li-Ping Huang, Peng Yang, Liang-Ping Ye, Chang-Hao Wu, Qi-Xing Zhu   +5 more
semanticscholar   +1 more source