Results 91 to 100 of about 3,935,620 (190)

Benzofuran–appended 4-aminoquinazoline hybrids as epidermal growth factor receptor tyrosine kinase inhibitors: synthesis, biological evaluation and molecular docking studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
A series of 2-arylbenzo[b]furan–appended 4-aminoquinazoline hybrids were prepared and evaluated for cytotoxicity in vitro against the human lung cancer (A549), colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A) and cervical cancer (HeLa ...
Malose J. Mphahlele, Marole M. Maluleka, Abimbola Aro, Lyndy J. McGaw, Yee Siew Choong   +4 more
doaj   +1 more source

Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells

Journal of Experimental Medicine, 2013
Blockade of C3aR/C5aR signaling in nT reg cells augments in vitro and in vivo suppression, abrogates autoimmune colitis, and prolongs allogeneic skin graft survival.
Wing-Hong Kwan, William van der Touw, E. Paz-Artal, Ming O. Li, P. Heeger   +4 more
semanticscholar   +1 more source

Antifungal activity of C3a and C3a-derived peptides against Candida [PDF]

, 2007
Antimicrobial peptides are generated during activation of the complement system [Nordahl et al. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:16879-16884].
Ringstad, Lovisa,, Sonesson, Andreas, Ringstad, Lovisa, Malmsten, Martin, Schmidtchen, Artur, Malmsten, Martin,, Mörgelin, M, Andersson Nordahl, Emma, Mörgelin, Matthias, Nordahl, Emma, Sonesson, A, Schmidtchen, A   +11 more
core   +1 more source

Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury

Journal of Neuroinflammation, 2010
Background Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy ...
Tsokos George C, Simovic Milomir, Dalle Lucca Shawn L, Li Yansong, Wang Ying, Dalle Lucca Jurandir J   +5 more
doaj   +1 more source

Identification of the C3a Receptor (C3AR1) as the Target of the VGF-derived Peptide TLQP-21 in Rodent Cells

Journal of Biological Chemistry, 2013
Background: TLQP-21 is a bioactive peptide for which the receptor(s) are unknown. Results: We demonstrate that C3AR1 is a receptor for TLQP-21. Conclusion: Many of the effects of TLQP-21 can be explained by C3AR1 activation.
S. Hannedouche, V. Beck, Juliet R. Leighton-Davies, M. Beibel, G. Roma, E. Oakeley, V. Lannoy, J. Bernard, Jacques Hamon, S. Barbieri, I. Preuss, Marie-Christine Lasbennes, A. Sailer, T. Suply, K. Seuwen, C. Parker, F. Bassilana   +16 more
semanticscholar   +1 more source

Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L [PDF]

, 2014
Molecular chaperones encompass a group of unrelated proteins that facilitate the correct assembly and disassembly of other macromolecular structures, which they themselves do not remain a part of.
Cato, L., Neeb, A., Brown, Myles, Cato, Andrew C. B., Cato, A. C. B., Neeb, Antje, Brown, M., Cato, Laura   +7 more
core   +1 more source

Complement Component 3C3 and C3a Receptor Are Required in Chitin-Dependent Allergic Sensitization to Aspergillus fumigatus but Dispensable in Chitin-Induced Innate Allergic Inflammation

mBio, 2013
Levels of the anaphylatoxin C3a are increased in patients with asthma compared with those in nonasthmatics and increase further still during asthma exacerbations.
René M Roy, H. Paes, S. Nanjappa, R. Sorkness, David J. Gasper, Alana K. Sterkel, Marcel Wüthrich, B. Klein   +7 more
semanticscholar   +1 more source

Supplementary Material for: The Anaphylatoxin C3a Receptor Expression on Human M2 Macrophages Is Down-Regulated by Stimulating the Histamine H4 Receptor and the IL-4 Receptor

, 2018
The anaphylatoxin C3a triggers inflammation by binding to its specific G-protein-coupled C3a receptor (C3aR). Since the number of C3aR, which is expressed on the cell surface, affects the response to C3a, we investigated the expression levels of C3aR on ...
Mommert S. (4152457), Stark H. (4152460), Werfel T. (4148740), Aslan D. (5539097), Ratz L. (5539100), Gutzmer R. (3355940)   +5 more
core   +1 more source

Complement C3a/C3aR inhibition alleviates the formation of aortic aneurysm in Marfan syndrome mice

BMC Cardiovascular Disorders
Mutations in fibrillin 1 (FBN1) is the main cause of Marfan syndrome (MFS) with thoracic aortic aneurysm (TAA) as the main complication. Activation of the complement system plays a key role in the formation of thoracic and abdominal aortic aneurysms ...
Fan Zhang, Kexin Yao, Yan Liu, Mei Zhou, Yanhong Zhang, Shiyao Hong, Jian Wu, Congcong Zhang   +7 more
doaj   +1 more source

The Complement C3a And C3a Receptor Pathway Indiabetic Patients With Entamobra Histolytica, Cryptospridium Parvum

International Journal of Environmental Sciences
Cryptosporidium parvum and Entamoeba histolytica are significant protozoan parasites that adversely impact human health. The infection rate of these parasites among diabetic patients was recorded at 18.33%. However, the mechanisms underlying host-parasite interactions remain poorly understood.
Bafreen Mohamad Raza, Naema Ali Ahmed, Sahlah Kh. Abbas   +2 more
openaire   +1 more source