Results 81 to 90 of about 3,935,620 (190)

Potent Heterocyclic Ligands for Human Complement C3a Receptor

, 2016
The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases.
Junxian Lim (1436800), Johan K. Hamidon (1730743), Martin J. Stoermer (777268), David P. Fairlie (180958), Mei-Kwan Yau (1436788), Robert C. Reid (1436797), Ranee Singh (1730740)   +6 more
core   +1 more source

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages.

PLoS Pathogens, 2022
The fungal pathogen Histoplasma capsulatum (Hc) invades, replicates within, and destroys macrophages. To interrogate the molecular mechanisms underlying this interaction, we conducted a host-directed CRISPR-Cas9 screen and identified 361 genes that ...
Allison Cohen, Edwin E Jeng, Mark Voorhies, Jane Symington, Nebat Ali, Rosa A Rodriguez, Michael C Bassik, Anita Sil   +7 more
doaj   +1 more source

C3A binds to the seven transmembrane anaphylatoxin receptor expressed by epithelial cells and triggers the production of IL-8 [PDF]

, 2001
The complement (C) plays an important role in many acute inflammatory processes. C3a is an inflammatory polypeptide named anaphylatoxin, generated during C activation and which acts through a specific receptor C3aR.
Fontaine, Marc, Tiphaine Monsinjon, Marc Fontaine, Alexander Ischenko, Ischenko, Alexander, Philippe Gasque, Monsinjon, Tiphaine, Gasque, Philippe   +7 more
core   +1 more source

Molecular Cloning and Characterization of the Human Anaphylatoxin C3a Receptor

Journal of Biological Chemistry, 1996
In a human neutrophil cDNA library, an orphan G-protein-coupled receptor, HNFAG09, with 37% nucleotide identity to the C5a receptor (C5a-R, CD88) was identified. A novel feature of this gene, unlike C5a-R and other G-protein-coupled receptors, is the presence of an extraordinarily large predicted extracellular loop comprised of in excess of 160 amino ...
R S, Ames, Y, Li, H M, Sarau, P, Nuthulaganti, J J, Foley, C, Ellis, Z, Zeng, K, Su, A J, Jurewicz, R P, Hertzberg, D J, Bergsma, C, Kumar   +11 more
openaire   +2 more sources

Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury [PDF]

, 2011
To prevent injury to host tissues, complement activation is regulated by a number of plasma and membrane-associated proteins, most of which limit C3 and C5 activation. An influx of circulating C3 from a syngeneic host into donor kidneys deficient in Crry
Lihua Bao, Mark Haas, Wang, Ying, Ying Wang, Richard J. Quigg, Haas, Mark, Bao, Lihua, Quigg, Richard J.   +7 more
core   +1 more source

C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent.

, 2008
The complement anaphylatoxin C3a contributes to injury after cerebral ischemia in mice. This study assesses the effect of C3a receptor antagonist (C3aRA) on leukocyte infiltration into the ischemic zone.
Otten, Marc L, Hassid, Benjamin G, Mack, William J, Sosunov, Sergei A, Ducruet, Andrew F, Kim, Grace H, Komotar, Ricardo J, Hickman, Zachary L, Ducruet, Andrew F., Mocco, J, Fusco, David J, Connolly, E Sander   +11 more
core   +1 more source

Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1

, 2003
Complement has recently been implicated in developmental pathways and noninflammatory processes. The expression of various complement components and receptors has been shown in a wide range of circulating myeloid and lymphoid cells, but their role in ...
L. A, J. D. AND RATAJCZAK M. Z., MASTELLOS, D, M, SPRUCE, RECA, R, MAREK HONCZARENKO, JANOWSKA WIECZOREK, RATAJCZAK, J, A, LAMBRIS, MARQUEZ, L, GLODEK, A, MAJKA, M, FRANCHINI, Silvia   +12 more
core   +1 more source

Activation of C3a receptor is required in cigarette smoke-mediated emphysema

Mucosal Immunology, 2014
Exposure to cigarette smoke can initiate sterile inflammatory responses in the lung and activate myeloid dendritic cells (mDCs) that induce differentiation of T helper type 1 (Th1) and Th17 cells in the emphysematous lungs.
Xiao-Yi Yuan, M. Shan, R. You, Michael V. Frazier, M. J. Hong, R. Wetsel, S. Drouin, A. Seryshev, Li-Zhen Song, Lorraine Cornwell, R. Rossen, D. Corry, F. Kheradmand   +12 more
semanticscholar   +1 more source

Regionally variable pulmonary artery responses to C3a

, 1988
Products of the complement (C) cascade may have direct effects on pulmonary vascular tissue and contribute to pulmonary vasoconstriction in states of C activation.
T. W. Chick, T. Anaya, W. P. Reed, D. Van Epps, D. E. Chenoweth, J. Leach, R. E. Crowell   +6 more
core   +1 more source

The C3a receptor, caspase-1, and release of IL-1β

Blood, 2013
In this issue of Blood, Asgari et al report that engagement of the C3a receptor triggers interleukin-1b (IL-1b) processing and release via caspase-1 activation. The role of complement activation in IL-1 production has a long history; complement products function as "alarmins" during innate responses.
openaire   +4 more sources