Results 101 to 110 of about 3,935,620 (190)

C3a targets the Hippo-YAP signaling pathway to promote Müller cells glial–mesenchymal transition in a high-glucose in vitro model

European Journal of Medical Research
Background Diabetic retinopathy (DR) is the most common microvascular complication of diabetes, severely affecting the health and quality of life of individuals with diabetes.
Shuang Liu, Long Suo, Hongliang Chen, Qiankun Wang, Dongyuan Mao, Yuanyuan Cai, Bing Qin   +6 more
doaj   +1 more source

Novel agonists & antagonists for protease-activated receptor 2 and C3a receptor [PDF]

, 2017
About 30–40% of all drugs currently in the market place target G-protein coupled receptors, however of the 900 plus GPCRs predicted to exist only about 30 are targeted by approved drugs. Two novel human GPCRs were investigated in this thesis, namely protease-activated receptor 2 (PAR2) and C3a receptor (C3aR).
openaire   +3 more sources

Complement peptide C3a promotes astrocyte survival in response to ischemia

, 2016
Astrocytes are the most numerous cells in the central nervous system with a range of homeostatic and regulatory functions. Under normal conditions as well as after ischemia, astrocytes promote neuronal survival.
Shinjyo, Noriko,, Pekna, Marcela,, Pekny, Milos,, de Pablo, Yolanda,   +3 more
core   +1 more source

Immunopharmacology and Inflammation G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2

, 2020
a b s t r a c t a r t i c l e i n f o Although human mast cells express G protein coupled receptors for the anaphylatoxin C3a, previous studies indicated that C3a causes mast cell degranulation, at least in part, via a C3a receptor-independent mechanism ...
Paola Magotti, Sarah J Collington, Sakeen W Kashem, John D Lambris, Hydar Ali, Hariharan Subramanian   +5 more
core  

Complement C3a binding to its receptor as a negative modulator of Th2 response in liver injury in trichloroethylene-sensitized mice.

, 2020
Trichloroethylene (TCE) is a major occupational health hazard and causes occupational medicamentosa-like dermatitis (OMLDT) and liver damage. Recent evidence suggests immune response as a distinct mode of action for TCE-induced liver damage.
Wang, H, Ye, LP, Zhang, JX, Li, SL, Zha, WS, Wu, CH, Shen, T, Zhu, QX, Wang, F   +8 more
core   +1 more source

Supplementary Figure 10 from An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype

The effects of C3a on GSCs and HBMECs.
Yaochuan Zhang (18099403), Sheng Han (18099421), Yifu Song (18099406), Mengwu Shi (18099412), Dongxia Tao (18099418), Xiaoliang Wang (18099409), Yibin Lin (18099415)   +6 more
core   +1 more source

Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury

GMS German Medical Science, 2010
Objective: Ischemic heart disease is the leading cause of death worldwide. The complement system plays a major role in inflammation and tissue injury following myocardial ischemia and reperfusion (MI/R) injury.
Stahl, Gregory L., Busche, Marc N.
doaj  

Supplementary Figure 8 from An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype

C3a/C3aR pathway played an important role in the positive regulation of TIM-3 expression by NFAT1.
Yaochuan Zhang (18099403), Sheng Han (18099421), Yifu Song (18099406), Mengwu Shi (18099412), Dongxia Tao (18099418), Xiaoliang Wang (18099409), Yibin Lin (18099415)   +6 more
core   +1 more source

Structural insights into small-molecule agonist recognition and activation of complement receptor C3aR

The EMBO Journal
The complement system plays crucial roles in innate immunity and inflammatory responses. The anaphylatoxin C3a mediates pro-inflammatory and chemotactic functions through the G protein-coupled receptor C3aR.
Jinuk Kim, Saebom Ko, Chulwon Choi, Jungnam Bae, Hyeonsung Byeon, Chaok Seok, Hee-Jung Choi   +6 more
doaj   +1 more source

Structural insights into agonist-binding and activation of the human complement C3a receptor

, 2023
Yadav MK, Yadav R, Sarma P, Maharana J, Soni C, Saha S, Singh V, Ganguly M, Saha S, Khant HA, Banerjee R, Shukla AK, Gati C.   +12 more
europepmc   +1 more source