The Role of the C3a-C3aR Pathway in Diseases: Latest Research Advances [PDF]
Mediators of InflammationC3a is a key active factor in the complement system, capable of participating in various physiological and pathological processes by binding to its C3a receptor (C3aR).
Xiangwei Bo +3 more
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SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling. [PDF]
Sci Rep, 2023 The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can interact with endothelial cells. However, no studies demonstrated the direct effect of the spike protein subunit 1 (S1) in inducing lung vascular damage and the ...
Perico L +8 more
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Knockout of the C3a receptor protects against renal ischemia reperfusion injury by reduction of NETs formation. [PDF]
Cell Mol Life Sci, 2023 Wu X +10 more
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Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury [PDF]
Journal of Neuroinflammation, 2010 Background Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy ...
Tsokos George C +5 more
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Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor [PDF]
Bioconjugate Chemistry, 2017 Measuring ligand affinity for a G protein-coupled receptor is often a crucial step in drug discovery. It has been traditionally determined by binding putative new ligands in competition with native ligand labeled with a radioisotope of finite lifetime.
Aline Dantas de Araujo +6 more
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Complement C3a receptor inactivation attenuates retinal degeneration induced by oxidative damage. [PDF]
Front Neurosci, 2022 Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. Evidence indicates that the activation of the complement system is associated with retinal degeneration.
Wang S, Du L, Yuan S, Peng GH.
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The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure. [PDF]
Nat Commun, 2022 Failure of the right ventricle plays a critical role in any type of heart failure. However, the mechanism remains unclear, and there is no specific therapy.
Ito S +34 more
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Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells. [PDF]
PLoS ONE, 2012 The anaphylatoxin C3a binds to the G protein coupled receptor (GPCR, C3aR) and activates divergent signaling pathways to induce degranulation and cytokine production in human mast cells. Adapter proteins such as the Na(+)/H(+) exchange regulatory factor (
Hariharan Subramanian +2 more
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Targeting Complement C3a Receptor to Improve Outcome After Ischemic Brain Injury. [PDF]
Neurochem Res, 2021 Ischemic stroke is a major cause of disability. No efficient therapy is currently available, except for the removal of the occluding blood clot during the first hours after symptom onset.
Pekna M, Stokowska A, Pekny M.
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Complement C3a receptor-mediated vascular dysfunction: a complex interplay between aging and neurodegeneration. [PDF]
J Clin Invest, 2021 Vascular dysfunction resulting in compromised blood-brain barrier (BBB) integrity is evident in aging and disease. Although the complement C3a/C3a receptor (C3a/C3aR) axis influences normal brain aging and disease progression, the mechanisms governing ...
Bhatia K +3 more
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