Phosphorylation of C3a receptor at multiple sites mediates desensitization, β-arrestin-2 recruitment and inhibition of NF-κB activity in mast cells. [PDF]
PLoS ONE, 2012 Phosphorylation of G protein coupled receptors (GPCRs) by G protein coupled receptor kinases (GRKs) and the subsequent recruitment of β-arrestins are important for their desensitization.
Kshitij Gupta +3 more
doaj +2 more sources
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. [PDF]
Cancer Res, 2018 The complement cascade is a part of the innate immune system which acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression.
Kwak JW +14 more
europepmc +2 more sources
Potent heterocyclic ligands for human complement c3a receptor.
Journal of Medicinal Chemistry, 2014 The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases.
R. Reid +6 more
semanticscholar +7 more sources
PLoS ONE, 2014 ObjectiveDiabetic nephropathy (DN) is a serious complication for patients with diabetes mellitus (DM). Emerging evidence suggests that complement C3a is involved in the progression of DN.
Ling Li +9 more
doaj +2 more sources
Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant. [PDF]
Am J Transplant, 2018 Donor brain death (BD) is an inherent part of lung transplantation (LTx) and a key contributor to ischemia‐reperfusion injury (IRI). Complement activation occurs as a consequence of BD in other solid organ Tx and exacerbates IRI, but the role of ...
Cheng Q +10 more
europepmc +2 more sources
The Anaphylatoxin C3a Receptor Expression on Human M2 Macrophages Is Down-Regulated by Stimulating the Histamine H4 Receptor and the IL-4 Receptor. [PDF]
J Innate Immun, 2018 The anaphylatoxin C3a triggers inflammation by binding to its specific G-protein-coupled C3a receptor (C3aR). Since the number of C3aR, which is expressed on the cell surface, affects the response to C3a, we investigated the expression levels of C3aR on ...
Mommert S +5 more
europepmc +2 more sources
C3a Enhances the Formation of Intestinal Organoids through C3aR1
Frontiers in Immunology, 2017 C3a is important in the regulation of the immune response as well as in the development of organ inflammation and injury. Furthermore, C3a contributes to liver regeneration but its role in intestinal stem cell function has not been studied.
Naoya Matsumoto +7 more
doaj +2 more sources
Human Plasmacytoid Dendritic Cells Express Receptors for Anaphylatoxins C3a and C5a and Are Chemoattracted to C3a and C5a [PDF]
Journal of Investigative Dermatology, 2006 The presence of plasmacytoid dendritic cells (pDC) was recently demonstrated in lesions of inflammatory skin diseases. Since anaphylatoxins or their precursors were also found in such lesions, we investigated a possible interaction between pDC and ...
Dorothea Dijkstra +15 more
core +5 more sources
Immunology, 2004 The anaphylatoxin C3a is an important inflammatory mediator in the innate and adaptive immune systems. Recent reports in various animal models have fostered the role of C3a in mediating allergic reactions such as pulmonary allergies.
Werfel, T. +15 more
core +5 more sources
Is the C3a receptor antagonist SB290157 a useful pharmacological tool? [PDF]
Br J Pharmacol, 2020 Lee JD, Taylor SM, Woodruff TM.
europepmc +2 more sources