C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis. [PDF]
Mucosal Immunol, 2018 Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease with an unknown etiology. Recent studies have implicated the complement system as a potential modulator of disease immunopathology. We performed proteomic pathway enrichment analysis of differentially increased proteins, and found an enrichment of complement cascade pathways ...
Mulligan JK +11 more
europepmc +5 more sources
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. [PDF]
Cancer Res, 2018 The complement cascade is a part of the innate immune system which acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression.
Kwak JW +14 more
europepmc +4 more sources
Anaphylatoxin C3a receptors in asthma [PDF]
Respiratory Research, 2005 The complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of complement activation, has long been known to activate mast cells, basophils ...
Panettieri Reynold A, Ali Hydar
doaj +4 more sources
Activation of C3a receptor is required in cigarette smoke-mediated emphysema. [PDF]
Mucosal Immunol, 2015 Exposure to cigarette smoke can initiate sterile inflammatory responses in the lung and activate myeloid dendritic cells (mDCs) that induce differentiation of T helper type 1 (Th1) and Th17 cells in the emphysematous lungs. Consumption of complement proteins increases in acute inflammation, but the contribution of complement protein 3 (C3) to chronic ...
Yuan X +12 more
europepmc +5 more sources
Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant. [PDF]
Am J Transplant, 2018 Donor brain death (BD) is an inherent part of lung transplantation (LTx) and a key contributor to ischemia‐reperfusion injury (IRI). Complement activation occurs as a consequence of BD in other solid organ Tx and exacerbates IRI, but the role of ...
Cheng Q +10 more
europepmc +4 more sources
Sulfation of Tyrosine 174 in the Human C3a Receptor Is Essential for Binding of C3a Anaphylatoxin [PDF]
Journal of Biological Chemistry, 2003 The complement anaphylatoxin C3a and its cellular seven-transmembrane segment receptor, C3aR, are implicated in a variety of pathological inflammatory processes. C3aR is a G-protein-coupled receptor with an exceptionally large second extracellular loop of 172 amino acids. Previously reported deletion studies have shown that at least part of this region
Jinming Gao +5 more
openalex +4 more sources
Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. [PDF]
PLoS ONE, 2011 The complement component C3a induces degranulation in human mast cells via the activation of cell surface G protein coupled receptors (GPCR; C3aR).
Arpana Vibhuti +4 more
doaj +3 more sources
Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases. [PDF]
PLoS ONE, 2011 The complement component C3a activates human mast cells via its cell surface G protein coupled receptor (GPCR) C3aR. For most GPCRs, agonist-induced receptor phosphorylation leads to receptor desensitization, internalization as well as activation of ...
Qiang Guo +3 more
doaj +2 more sources
Expression of a Functional Anaphylatoxin C3a Receptor by Astrocytes [PDF]
Journal of Neurochemistry, 1998 Abstract: Human astrocyte cell lines reportedly contain a specific receptor for the complement anaphylatoxin C3a based on ligand‐binding studies, functional responses, and RNA analysis by RT‐PCR. Uptake of 125I‐C3a by astrocytes was specific and reversible. Scatchard analysis indicated the presence of two classes of binding sites. High‐affinity binding
Philippe Gasque
exaly +3 more sources
Modulation of C3a Activity: Internalization of the Human C3a Receptor and its Inhibition by C5a [PDF]
The Journal of Immunology, 1999 Abstract The C3a receptor (C3aR) is expressed on most human peripheral blood leukocytes with the exception of resting lymphocytes, implying a much higher pathophysiological relevance of the anaphylatoxin C3a as a proinflammatory mediator than previously thought.
Britta Settmacher +7 more
openalex +3 more sources