PET radiotracer targeting the complement C3a receptor. [PDF]
Nucl Med BiolBackground Positron-emission tomography (PET) imaging of the complement system could advance understanding of the innate immune system in central nervous system (CNS) diseases and development of new drugs.
Naik R +11 more
europepmc +5 more sources
Anaphylatoxin C3a receptors in asthma [PDF]
Respiratory Research, 2005 The complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of complement activation, has long been known to activate mast cells, basophils ...
Panettieri Reynold A, Ali Hydar
doaj +7 more sources
Complement C3a receptor-mediated vascular dysfunction: a complex interplay between aging and neurodegeneration. [PDF]
J Clin Invest, 2021 Vascular dysfunction resulting in compromised blood-brain barrier (BBB) integrity is evident in aging and disease. Although the complement C3a/C3a receptor (C3a/C3aR) axis influences normal brain aging and disease progression, the mechanisms governing ...
Bhatia K +3 more
europepmc +3 more sources
The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. [PDF]
PLoS ONE, 2013 Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying pathomechanisms in order to identify new therapeutic targets.
Elisabeth Wende +6 more
doaj +3 more sources
Species-specific differences in regulation of macrophage inflammation by the C3a-C3a receptor axis. [PDF]
Innate Immun, 2018 Complement is an important arm of the innate immune system. Recent studies have shown that products of complement pathway activation can interact directly with other innate immune signaling molecules, including TLRs and inflammasome family members ...
Ray TD +5 more
europepmc +5 more sources
C3a Receptor Inhibition Protects Brain Endothelial Cells Against Oxygen-glucose Deprivation/Reperfusion. [PDF]
Exp Neurobiol, 2019 The complement cascade is a central component of innate immunity which plays a critical role in brain inflammation. Complement C3a receptor (C3aR) is a key mediator of post-ischemic cerebral injury, and pharmacological antagonism of the C3a receptor is ...
Ahmad S +6 more
europepmc +3 more sources
Derivation of ligands for the complement C3a receptor from the C-terminus of C5a. [PDF]
European Journal of Pharmacology, 2014 The complement cascade is a highly sophisticated network of proteins that are well regulated and directed in response to invading pathogens or tissue injury.
Daniel Croker +2 more
exaly +3 more sources
Autoantibody-Mediated Complement C3a Receptor Activation Contributes to the Pathogenesis of Preeclampsia [PDF]
Hypertension, 2012 Preeclampsia (PE) is a prevalent life-threatening hypertensive disorder of pregnancy associated with increased complement activation. However, the causative factors and pathogenic role of increased complement activation in PE are largely unidentified ...
Rodney E Kellems +2 more
exaly +3 more sources
Hyperactive Behavior and Altered Brain Morphology in Adult Complement C3a Receptor Deficient Mice. [PDF]
Front Immunol, 2021 The C3a receptor (C3aR) is a seven trans-membrane domain G-protein coupled receptor with a range of immune modulatory functions. C3aR is activated by the third complement component (C3) activation derived peptide C3a and a neuropeptide TLQP-21.
Pozo-Rodrigálvarez A +4 more
europepmc +2 more sources
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging. [PDF]
J Clin Invest, 2021 Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer's disease; however, their interrelatedness remains poorly understood. The complement pathway is a well-established regulator of innate immunity in the brain.
Propson NE +4 more
europepmc +2 more sources