The Complement C3a and C3a Receptor Pathway in Kidney Diseases [PDF]
Frontiers in Immunology, 2020 The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role.
Shuang Gao +12 more
doaj +9 more sources
Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism [PDF]
Frontiers in Immunology, 2021 Complement component 3 fragment C3a is an anaphylatoxin involved in promoting cellular responses important in immune response and host defense. Its receptor (C3a receptor, C3aR) is distributed on the plasma membrane; however, lysosomal localization in ...
Masaaki Ishii +5 more
doaj +6 more sources
The Complex Role of the Complement C3a Receptor (C3aR) in Cerebral Injury and Recovery Following Ischemic Stroke [PDF]
CellsThe Complement C3a Receptor (C3aR) plays a multifaceted role along the varying temporal phases of brain injury following cerebral ischemia. C3aR is a G-protein-coupled receptor (GPCR) that binds to its ligand, C3a an anaphylatoxin generated during ...
Naseem Akhter +6 more
doaj +5 more sources
Deficiency of C3a receptor attenuates the development of diabetic nephropathy [PDF]
BMJ Open Diabetes Research & Care, 2019 Objective Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and end-stage renal disease. Emerging evidence suggests that complement activation is involved in the pathogenesis of DN.
Ming-hui Zhao +2 more
doaj +6 more sources
Species-specific differences in regulation of macrophage inflammation by the C3a-C3a receptor axis. [PDF]
Innate Immun, 2018 Complement is an important arm of the innate immune system. Recent studies have shown that products of complement pathway activation can interact directly with other innate immune signaling molecules, including TLRs and inflammasome family members, during some infectious and chronic inflammatory disorders.
Ray TD +5 more
europepmc +6 more sources
Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy. [PDF]
J Am Soc Nephrol, 2022 Background The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN.
Gao S, Cui Z, Zhao MH.
europepmc +4 more sources
C3a Receptor Signaling Inhibits Neurodegeneration Induced by Neonatal Hypoxic-Ischemic Brain Injury [PDF]
Frontiers in Immunology, 2021 Hypoxic-ischemic neonatal encephalopathy due to perinatal asphyxia is the leading cause of brain injury in newborns. Clinical data suggest that brain inflammation induced by perinatal insults can persist for years.
Andrea Pozo-Rodrigálvarez +13 more
doaj +3 more sources
Hyperactive Behavior and Altered Brain Morphology in Adult Complement C3a Receptor Deficient Mice. [PDF]
Front Immunol, 2021 The C3a receptor (C3aR) is a seven trans-membrane domain G-protein coupled receptor with a range of immune modulatory functions. C3aR is activated by the third complement component (C3) activation derived peptide C3a and a neuropeptide TLQP-21.
Pozo-Rodrigálvarez A +4 more
europepmc +4 more sources
Genomic organization of the human C3a receptor [PDF]
European Journal of Immunology, 1998 The human C3a receptor (C3aR) mediates the activation of cells by the potent proinflammatory chemoattractant C3a, an anaphylatoxin, generated in the early phase of an inflammatory reaction by proteolytic cleavage of the complement component C3. To understand the molecular mechanisms that regulate C3aR gene expression, we initiated studies to determine ...
Jörg Kohl, Andreas Klos
exaly +4 more sources
PLoS ONE, 2014 ObjectiveDiabetic nephropathy (DN) is a serious complication for patients with diabetes mellitus (DM). Emerging evidence suggests that complement C3a is involved in the progression of DN.
Ling Li +9 more
doaj +4 more sources