Results 21 to 30 of about 3,979 (154)

Astrocyte-to-neuron interaction via NF-κB/C3/C3aR mediates chronic post-thoracotomy pain by modulating neuronal GluR1 in spinal dorsal horn. [PDF]

iScience
Summary: Chronic post-thoracotomy pain (CPTP) is a debilitating postoperative complication associated with persistent hypersensitivity and neuroinflammatory changes.
Mou W, Yu N, Sun F, Cui H, Zhang H, Cao Y, Jin S, Ma C, Zhu A, Ma L, Huang Y.   +10 more
europepmc   +2 more sources

Bindarit attenuates brain injury and neuroinflammation in status epilepticus by disrupting C3/C3aR signaling and modulating microglia-astrocyte interactions. [PDF]

Cell Commun Signal
Background Status epilepticus (SE) is a life-threatening neurological emergency with high mortality, often leading to acute cerebral edema and chronic cognitive impairment. Its pathology involves both immune and vascular dysfunction.
Chen J, Hu Y, Xie J, Zhou H, Yang T, Yu M, Wu J, Pan S, Huang K.   +8 more
europepmc   +2 more sources

The complement C3a/C3aR pathway is associated with treatment resistance to gemcitabine-based neoadjuvant therapy in pancreatic cancer

Computational and Structural Biotechnology Journal
Gemcitabine is a standard first-line drug for pancreatic cancer chemotherapy. Nevertheless, gemcitabine resistance is common and significantly limits its therapeutic efficacy, impeding advancements in pancreatic cancer treatment. In this study, through a
Saimeng Shi, Longyun Ye, Kaizhou Jin, Xianjun Yu, Duancheng Guo, Weiding Wu   +5 more
doaj   +2 more sources

Hyperactive Behavior and Altered Brain Morphology in Adult Complement C3a Receptor Deficient Mice

Frontiers in Immunology, 2021
The C3a receptor (C3aR) is a seven trans-membrane domain G-protein coupled receptor with a range of immune modulatory functions. C3aR is activated by the third complement component (C3) activation derived peptide C3a and a neuropeptide TLQP-21.
Andrea Pozo-Rodrigálvarez, Roosa Ollaranta, Jenny Skoog, Milos Pekny, Milos Pekny, Milos Pekny, Marcela Pekna, Marcela Pekna, Marcela Pekna   +8 more
doaj   +1 more source

The Complement C3a and C3a Receptor Pathway in Kidney Diseases

Frontiers in Immunology, 2020
The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role.
Shuang Gao, Shuang Gao, Shuang Gao, Shuang Gao, Zhao Cui, Zhao Cui, Zhao Cui, Zhao Cui, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao   +12 more
doaj   +1 more source

Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases. [PDF]

PLoS ONE, 2011
The complement component C3a activates human mast cells via its cell surface G protein coupled receptor (GPCR) C3aR. For most GPCRs, agonist-induced receptor phosphorylation leads to receptor desensitization, internalization as well as activation of ...
Qiang Guo, Hariharan Subramanian, Kshitij Gupta, Hydar Ali   +3 more
doaj   +1 more source

Shiga Toxin 2 Triggers C3a-Dependent Glomerular and Tubular Injury through Mitochondrial Dysfunction in Hemolytic Uremic Syndrome

Cells, 2022
Shiga toxin (Stx)-producing Escherichia coli is the predominant offending agent of post-diarrheal hemolytic uremic syndrome (HUS), a rare disorder of microvascular thrombosis and acute kidney injury possibly leading to long-term renal sequelae.
Simona Buelli, Monica Locatelli, Claudia Elisa Carminati, Daniela Corna, Domenico Cerullo, Barbara Imberti, Luca Perico, Maurizio Brigotti, Mauro Abbate, Carlamaria Zoja, Ariela Benigni, Giuseppe Remuzzi, Marina Morigi   +12 more
doaj   +1 more source

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

Journal of Experimental & Clinical Cancer Research, 2020
Background Mounting evidence suggests that complement components promote tumor progression via modulating immune suppression, angiogenesis, or tumor cell proliferation.
Chi Shu, Haoran Zha, Haixia Long, Xinxin Wang, Fei Yang, Jianbao Gao, Chunyan Hu, Li Zhou, Bo Guo, Bo Zhu   +9 more
doaj   +1 more source

C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction

Journal of Hematology & Oncology, 2022
Although chimeric antigen receptor (CAR)-modified adoptive T cell therapy is a promising immunotherapy for hematological malignancies, the efficacy improvement in relapsed/refractory acute lymphoblastic leukemia (ALL) with extramedullary infiltration and
Peilong Lai, Xiaomei Chen, Yulian Wang, Jinghua Wang, Yuchen Zhang, Suxia Geng, Peng Li, Xin Du, Jianyu Weng, Duanqing Pei   +9 more
doaj   +1 more source

Changes of complement fragment C3a and its receptor in lung injury induced by silica nanoparticles

环境与职业医学, 2023
BackgroundSilica nanoparticles (SiNPs) enter the human body through respiratory tract, digestive tract, and skin, causing body damage. Lung is one of the main damaged organs.
Sifan ZHOU, Zhoujian WANG, Lei GAO, Yuansheng DUAN, Muyue CHEN, Jiaxiang ZHANG, Qixing ZHU   +6 more
doaj   +1 more source