Results 21 to 30 of about 5,430 (207)

C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARα/CPT-1α Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension

Frontiers in Bioscience-Landmark, 2023
Background: Renin-dependent hypertension with tubulointerstitial injury remains a problem with high prevalence in the clinic. However, whether and how renin participates in tubulointerstitial injury remains incompletely understood.
Chongjian Wang, Zhiyu Wang, Jing Xu, Hongkun Ma, Kexin Jin, Tingting Xu, Xiaoxia Pan, Xiaobei Feng, Wen Zhang   +8 more
doaj   +1 more source

The Complement C3a and C3a Receptor Pathway in Kidney Diseases

Frontiers in Immunology, 2020
The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role.
Shuang Gao, Shuang Gao, Shuang Gao, Shuang Gao, Zhao Cui, Zhao Cui, Zhao Cui, Zhao Cui, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao   +12 more
doaj   +1 more source

Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases. [PDF]

PLoS ONE, 2011
The complement component C3a activates human mast cells via its cell surface G protein coupled receptor (GPCR) C3aR. For most GPCRs, agonist-induced receptor phosphorylation leads to receptor desensitization, internalization as well as activation of ...
Qiang Guo, Hariharan Subramanian, Kshitij Gupta, Hydar Ali   +3 more
doaj   +1 more source

C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy [PDF]

JCI Insight
The deposition of antipodocyte autoantibodies in the glomerular subepithelial space induces primary membranous nephropathy (MN), the leading cause of nephrotic syndrome worldwide.
Qi Zhang, Sofia Bin, Kelly Budge, Astgik Petrosyan, Valentina Villani, Paola Aguiari, Coralien Vink, Jack Wetzels, Hasmik Soloyan, Gaetano La Manna, Manuel Alfredo Podestà, Paolo Molinari, Sargis Sedrakyan, Kevin V. Lemley, Roger E. De Filippo, Laura Perin, Paolo Cravedi, Stefano Da Sacco   +17 more
doaj   +5 more sources

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

Journal of Experimental & Clinical Cancer Research, 2020
Background Mounting evidence suggests that complement components promote tumor progression via modulating immune suppression, angiogenesis, or tumor cell proliferation.
Chi Shu, Haoran Zha, Haixia Long, Xinxin Wang, Fei Yang, Jianbao Gao, Chunyan Hu, Li Zhou, Bo Guo, Bo Zhu   +9 more
doaj   +1 more source

Correction to: C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum [PDF]

Journal of Neuroinflammation, 2020
Following publication of the original article, the authors noticed missing labels in Fig ...
Kevin G. Young, Keqin Yan, David J. Picketts   +2 more
openaire   +3 more sources

C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction

Journal of Hematology & Oncology, 2022
Although chimeric antigen receptor (CAR)-modified adoptive T cell therapy is a promising immunotherapy for hematological malignancies, the efficacy improvement in relapsed/refractory acute lymphoblastic leukemia (ALL) with extramedullary infiltration and
Peilong Lai, Xiaomei Chen, Yulian Wang, Jinghua Wang, Yuchen Zhang, Suxia Geng, Peng Li, Xin Du, Jianyu Weng, Duanqing Pei   +9 more
doaj   +1 more source

Shiga Toxin 2 Triggers C3a-Dependent Glomerular and Tubular Injury through Mitochondrial Dysfunction in Hemolytic Uremic Syndrome

Cells, 2022
Shiga toxin (Stx)-producing Escherichia coli is the predominant offending agent of post-diarrheal hemolytic uremic syndrome (HUS), a rare disorder of microvascular thrombosis and acute kidney injury possibly leading to long-term renal sequelae.
Simona Buelli, Monica Locatelli, Claudia Elisa Carminati, Daniela Corna, Domenico Cerullo, Barbara Imberti, Luca Perico, Maurizio Brigotti, Mauro Abbate, Carlamaria Zoja, Ariela Benigni, Giuseppe Remuzzi, Marina Morigi   +12 more
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Protective role for C3aR in experimental chronic pyelonephritis

The FASEB Journal, 2022
Abstract Emerging evidence suggest that C3aR plays important roles in homeostasis, host defense and disease. Although it is known that C3aR is protective in several models of acute bacterial infections, the role for C3aR in chronic infection is largely unknown.
Shu‐Juan Zhao, Kun‐Yi Wu, Xiao‐Yun Min, Chun‐Xuan Wang, Bo Cao, Ning Ma, Xue‐Ling Yang, Zhuo‐Ran Zhu, Rong‐Guo Fu, Wuding Zhou, Ju‐Rong Yang, Ke Li   +11 more
openaire   +3 more sources

Changes of complement fragment C3a and its receptor in lung injury induced by silica nanoparticles

环境与职业医学, 2023
BackgroundSilica nanoparticles (SiNPs) enter the human body through respiratory tract, digestive tract, and skin, causing body damage. Lung is one of the main damaged organs.
Sifan ZHOU, Zhoujian WANG, Lei GAO, Yuansheng DUAN, Muyue CHEN, Jiaxiang ZHANG, Qixing ZHU   +6 more
doaj   +1 more source