Results 1 to 10 of about 1,032 (106)

C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages [PDF]

Cells, 2023
The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages.
Eva-Maria Nichols, Van Dien Nguyen, Lee M Booty   +2 more
exaly   +4 more sources

C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages [PDF]

Journal of Immunology Research
As another receptor for complement activation product C5a, C5aR2 has been paid much attention these years. Although controversial and complex, its specific signals or roles in modulating the classic receptor C5aR1 have been investigated and gradually ...
Ting Zhang, Ning Ma, Jiaxing Wang, Xiaoyun Min, Linlin Wei, Ke Li   +5 more
doaj   +3 more sources

The insider's perspective: The intracellular complosome and immune cell dynamics in cancer [PDF]

Clinical and Translational Medicine
Complement is increasingly recognised as a driver and modulator of antitumour immunity, with context‐dependent effects across T cells, myeloid subsets, stromal elements and tumour cells.
Alexandra Bennion, Joanne Lysaght, Niamh Lynam‐Lennon   +2 more
doaj   +3 more sources

Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction [PDF]

Cell Discovery
Complement-mediated metabolic disorders are considered important contributors to the pathogenesis of diabetic kidney disease (DKD). This study investigated the non-canonical roles of complement 5a receptor 2 (C5aR2) in metabolism and its underlying ...
Yi-yang Zhao, Yi-hui Wang, Zi-han Li, Dong-yuan Chang, Lin Nie, Ming-hui Zhao, Sydney Chi Wai Tang, Min Chen   +7 more
doaj   +2 more sources

Complement tumor-crosstalk: the role of C5a receptors in urothelial carcinomas [PDF]

Frontiers in Immunology
Urothelial carcinoma, the second most common urological malignancy, can arise in both the lower and upper urinary tract, with approximately 90–95% arising in the bladder, while urothelial carcinomas of the upper urinary tract account for only 5–10 ...
Lea Sophie Lütje, Caroline Gruner, Christian Marcel Karsten, Axel Stuart Merseburger, Marie Christine Roesch   +4 more
doaj   +2 more sources

An integrated analysis of C5AR2 related to malignant properties and immune infiltration of gliomas

Cancer Innovation, 2022
Background C5AR2 is recognized as a proinflammatory molecule and activates the inflammatory response in multiple disorders. However, little has been reported on C5AR2 in glioma.
Shanqiang Qu, Ouwen Qiu
exaly   +2 more sources

Unveiling immune mechanisms and potential biomarkers in intervertebral disc degeneration through integrated analysis [PDF]

Brazilian Journal of Medical and Biological Research
Immune regulation plays an important role in the pathogenesis of intervertebral disc degeneration (IDD). However, the mechanism of immune regulation in IDD is still unclear. All IDD data were downloaded from a public database.
Xuehu Xie, Guoqiang Zhang, Ning Liu
doaj   +2 more sources

Role of C5aR2 in prognosis of patients with acute respiratory distress syndrome through negative modulation of C5a: A prospective observational study [PDF]

Heliyon
Objective: Diverse inflammatory pathology is involved in acute respiratory distress syndrome (ARDS). This study aimed to assess the role of complement component fragment 5a (C5a) receptor 2 (C5aR2) in prognosis of patients with ARDS.
Muhammed Rashid, Sreedharan Nair, Pooja Gopal Poojari, Vijetha Shenoy Belle, Vijayanarayana Kunhikatta, Daniel A. Vaz, Vishal Shanbhag, Viji Pulikkel Chandran, Shravya Chitrapady, Girish Thunga   +9 more
doaj   +2 more sources

Selective Complement Inhibition in Anti-p200 Pemphigoid: Immune Infiltrate Profiles and Therapeutic Implications Compared to Bullous Pemphigoid [PDF]

Biomolecules
Anti-p200 pemphigoid is an autoimmune blistering disease (AIBD) caused by autoantibodies against laminin β4 and/or γ1, and clinically resembles bullous pemphigoid (BP) as well as the inflammatory variant of epidermolysis bullosa acquisita (EBA).
Shirin Emtenani, Tina Rastegar Lari, Charlotte Kiehne, Nina van Beek, Maike M. Holtsche, Enno Schmidt   +5 more
doaj   +2 more sources

Inhibition of Alternative and Terminal Complement Pathway Components Modulate the Immune Response Against Bacteria and Fungi in Whole Blood. [PDF]

Scand J Immunol
Complement inhibition (factor D, C3, C5, or C5aR1) blunts inflammation induced by Escherichia coli or Aspergillus fumigatus conidia in lepirudin‐treated whole blood. Inhibition decreases inflammatory markers, reduces anaphylatoxin receptor expression, and lowers cytokine production and phagocytic activity. Created in https://BioRender.com.
Cyranka L, Mariegaard I, Fageräng B, Pérez-Alós L, Harpf V, Mollnes TE, Garred P, Rosbjerg A.   +7 more
europepmc   +2 more sources