C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages [PDF]
Cells, 2023 The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages.
Oliver Wright +2 more
exaly +10 more sources
Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy [PDF]
Frontiers in ImmunologyPregnancy is a fascinating immunological phenomenon because it allows allogeneic fetal and placental tissues to survive inside the mother. As a component of innate immunity with high inflammatory potential, the complement system must be tightly regulated
Tamara Tilburgs
exaly +7 more sources
The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita [PDF]
Frontiers in Immunology, 2023 IntroductionThe function of the second receptor for the complement cleavage product C5a, C5aR2, is poorly understood and often neglected in the immunological context.
Christian D Sadik +2 more
exaly +4 more sources
Frontiers in Oncology, 2021 BackgroundC5AR2 (GPR77, C5L2) is the second receptor for C5a that is a potent protein generated by complement activation. C5AR2 can mediate its own signaling events and exert significant immunomodulatory effects through those events. However, research of
Yumeng Zhu +2 more
exaly +3 more sources
Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction [PDF]
Cell DiscoveryComplement-mediated metabolic disorders are considered important contributors to the pathogenesis of diabetic kidney disease (DKD). This study investigated the non-canonical roles of complement 5a receptor 2 (C5aR2) in metabolism and its underlying ...
Yi-yang Zhao +7 more
doaj +2 more sources
Role of C5aR2 in prognosis of patients with acute respiratory distress syndrome through negative modulation of C5a: A prospective observational study [PDF]
HeliyonObjective: Diverse inflammatory pathology is involved in acute respiratory distress syndrome (ARDS). This study aimed to assess the role of complement component fragment 5a (C5a) receptor 2 (C5aR2) in prognosis of patients with ARDS.
Muhammed Rashid +9 more
doaj +2 more sources
Unveiling immune mechanisms and potential biomarkers in intervertebral disc degeneration through integrated analysis [PDF]
Brazilian Journal of Medical and Biological ResearchImmune regulation plays an important role in the pathogenesis of intervertebral disc degeneration (IDD). However, the mechanism of immune regulation in IDD is still unclear. All IDD data were downloaded from a public database.
Xuehu Xie, Guoqiang Zhang, Ning Liu
doaj +2 more sources
C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages [PDF]
Journal of Immunology ResearchAs another receptor for complement activation product C5a, C5aR2 has been paid much attention these years. Although controversial and complex, its specific signals or roles in modulating the classic receptor C5aR1 have been investigated and gradually ...
Ting Zhang +5 more
doaj +2 more sources
An integrated analysis of C5AR2 related to malignant properties and immune infiltration of gliomas
Cancer Innovation, 2022 Background C5AR2 is recognized as a proinflammatory molecule and activates the inflammatory response in multiple disorders. However, little has been reported on C5AR2 in glioma.
Chengying Huang +2 more
exaly +2 more sources
Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling [PDF]
Immunology and Cell Biology, 2016 The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two seven transmembrane receptors, namely
Daniel E Croker +2 more
exaly +3 more sources