Results 21 to 30 of about 1,082 (137)
Frontiers in Immunology, 2022 Bullous pemphigoid (BP), the by far most frequent autoimmune subepidermal blistering disorder (AIBD), is characterized by the deposition of autoantibodies against BP180 (type XVII collagen; Col17) and BP230 as well as complement components at the dermal ...
Shirin Emtenani +18 more
doaj +1 more source
Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse [PDF]
The Journal of Immunology, 2017 Abstract The biological significance of C5a receptor [(C5aR)2/C5L2], a seven-transmembrane receptor binding C5a and C5adesArg, remains ill-defined. Specific ligation of C5aR2 inhibits C5a-induced ERK1/2 activation, strengthening the view that C5aR2 regulates C5aR1-mediated effector functions.
Christian M Karsten +16 more
openaire +4 more sources
Corrigendum to “The Controversial C5a Receptor C5aR2: Its Role in Health and Disease” [PDF]
Journal of Immunology Research, 2017 [This corrects the article DOI: 10.1155/2017/8193932.].
Ting Zhang, Malgorzata A. Garstka, Ke Li
doaj +3 more sources
The ‘C3aR antagonist’ SB290157 is a partial C5aR2 agonist [PDF]
, 2020 ABSTRACT Innate immune complement activation generates the C3 and C5 protein cleavage products C3a and C5a, defined classically as anaphylatoxins. C3a activates C3a receptors (C3aR), while C5a activates two receptors (C5aR1 and C5aR2) to exert their immunomodulatory activities.
Xaria X. Li +3 more
openaire +1 more source
C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages [PDF]
The Journal of Immunology, 2020 Abstract The complement activation fragment C5a is a potent proinflammatory mediator that is increasingly recognized as an immune modulator. C5a acts through two C5a receptors, C5aR1 (C5aR, CD88) and C5aR2 (C5L2, GPR77), to powerfully modify multiple aspects of immune cell function.
Xaria X Li +2 more
openaire +5 more sources
The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity [PDF]
The Journal of Immunology, 2019 Abstract Complement activation generates the core effector protein C5a, a potent immune molecule that is linked to multiple inflammatory diseases. Two C5a receptors, C5aR1 (C5aR, CD88) and C5aR2 (C5L2, GPR77), mediate the biological activities of C5a.
Xaria X Li +3 more
openaire +5 more sources
Scientific Reports, 2021 Singular blockade of C5a in experimental models of sepsis is known to confer protection by rescuing lethality and decreasing pro-inflammatory responses.
Shinjini Chakraborty +10 more
doaj +1 more source
Helix 8 in chemotactic receptors of the complement system.
PLoS Computational Biology, 2022 Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski +3 more
doaj +1 more source
TLQP-21 is a low potency partial C3aR activator on human primary macrophages
Frontiers in Immunology, 2023 TLQP-21 is a 21-amino acid neuropeptide derived from the VGF precursor protein. TLQP-21 is expressed in the nervous system and neuroendocrine glands, and demonstrates pleiotropic roles including regulating metabolism, nociception and microglial functions.
Xaria X. Li +4 more
doaj +1 more source
Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
Journal of Neuroinflammation, 2022 Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of ...
Klebea Carvalho +10 more
doaj +1 more source