Results 21 to 30 of about 1,622 (169)

IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction [PDF]

Frontiers in Immunology, 2018
Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory
Hilde L. Orrem, Hilde L. Orrem, Hilde L. Orrem, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Søren E. Pischke, Søren E. Pischke, Søren E. Pischke, Ola Kleveland, Ola Kleveland, Arne Yndestad, Arne Yndestad, Arne Yndestad, Arne Yndestad, Arne Yndestad, Karin Ekholt, Karin Ekholt, Jan K. Damås, Terje Espevik, Bjørn Bendz, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Ida Gregersen, Ida Gregersen, Rune Wiseth, Rune Wiseth, Geir Ø. Andersen, Geir Ø. Andersen, Geir Ø. Andersen, Thor Ueland, Thor Ueland, Thor Ueland, Thor Ueland, Thor Ueland, Lars Gullestad, Lars Gullestad, Lars Gullestad, Pål Aukrust, Pål Aukrust, Pål Aukrust, Pål Aukrust, Andreas Barratt-Due, Andreas Barratt-Due, Andreas Barratt-Due, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes   +54 more
doaj   +3 more sources

The complement system in human pregnancy and preeclampsia [PDF]

Frontiers in Immunology
Human pregnancy is a complex condition that poses significant challenges for women due to the necessity of a uterus for key processes such as fertilization, embryo implantation, fetal development, and childbirth.
Vijay Kumar, John H. Stewart
doaj   +2 more sources

The role of the complement system in the response to cytotoxic therapy. [PDF]

Semin Immunol
The complement system is increasingly recognised as a key player in tumour progression and response to cancer treatment. Cytotoxic therapies, including chemo- and radiotherapy are standard-of-care for the majority of cancer patients. Cytotoxics have been
Lee KSW, Zhang Q, Suwa T, Clark H, Olcina MM.   +4 more
europepmc   +3 more sources

Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis [PDF]

Critical Care Explorations
IMPORTANCE:. The alternative complement pathway is a key component of host defense against bacteremia and other infections. However, dysregulated activation can contribute to excessive inflammation and worse clinical outcomes during bacteremia and ...
Kyle Inman, MD, Jonathan Chernus, PhD, Myoungkeun Lee, MS, Jonathan K. Alder, PhD, Faraaz Ali Shah, MD, Florian B. Mayr, MD, Timothy Dempsey, MD, S. Mehdi Nouraie, MD, PhD, Charles Dela Cruz, MD, PhD, Viviana P. Ferreira, DVM, PhD, Hrishikesh S. Kulkarni, MD, Nuala J. Meyer, MD, Patrick J. Strollo, MD, Eleanor Feingold, PhD, William Bain, MD   +14 more
doaj   +2 more sources

Distinct and mutually exclusive Ca2+ flux- and adenylyl cyclase-inducing gene expression profiles of G-protein-coupled receptors on human antigen-specific B cells [PDF]

, 2023
Allergy, Volume 78, Issue 11, Page 3016-3019, November 2023.
Akdis, Cezmi A, Akdis, Mübeccel, Babayev, Huseyn, Buergi, Laura, Chang, Iris, Kaushik, Abhinav, Nadeau, Kari, Satitsuksanoa, Pattraporn, Schneider, Stephan R, van de Veen, Willem, Yang, Minglin   +10 more
core   +2 more sources

Inhibition of Alternative and Terminal Complement Pathway Components Modulate the Immune Response Against Bacteria and Fungi in Whole Blood. [PDF]

Scand J Immunol
Complement inhibition (factor D, C3, C5, or C5aR1) blunts inflammation induced by Escherichia coli or Aspergillus fumigatus conidia in lepirudin‐treated whole blood. Inhibition decreases inflammatory markers, reduces anaphylatoxin receptor expression, and lowers cytokine production and phagocytic activity. Created in https://BioRender.com.
Cyranka L, Mariegaard I, Fageräng B, Pérez-Alós L, Harpf V, Mollnes TE, Garred P, Rosbjerg A.   +7 more
europepmc   +2 more sources

Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients

Frontiers in Immunology, 2022
Bullous pemphigoid (BP), the by far most frequent autoimmune subepidermal blistering disorder (AIBD), is characterized by the deposition of autoantibodies against BP180 (type XVII collagen; Col17) and BP230 as well as complement components at the dermal ...
Shirin Emtenani, Maike M. Holtsche, Richard Stahlkopf, Daniel L. Seiler, Timothy Burn, Huiqing Liu, Melissa Parker, Kaan Yilmaz, Hasan O. Dikmen, Markus Huber Lang, Christian D. Sadik, Christian M. Karsten, Nina van Beek, Ralf J. Ludwig, Ralf J. Ludwig, Jörg Köhl, Jörg Köhl, Enno Schmidt, Enno Schmidt   +18 more
doaj   +1 more source

Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse [PDF]

The Journal of Immunology, 2017
Abstract The biological significance of C5a receptor [(C5aR)2/C5L2], a seven-transmembrane receptor binding C5a and C5adesArg, remains ill-defined. Specific ligation of C5aR2 inhibits C5a-induced ERK1/2 activation, strengthening the view that C5aR2 regulates C5aR1-mediated effector functions.
Christian M Karsten, Anna V Wiese, Fabian Mey, Julia Figge, Trent M Woodruff, Tom Reuter, Olga Scurtu, Anna Kordowski, Larissa N Almeida, Daria Briukhovetska, Katharina M Quell, Jing Sun, Fanny Ender, Inken Schmudde, Tillman Vollbrandt, Yves Laumonnier, Jörg Köhl   +16 more
openaire   +4 more sources

C5aR2 Deficiency Ameliorates Inflammation in Murine Epidermolysis Bullosa Acquisita by Regulating Fcγ Receptor Expression on Neutrophils [PDF]

, 2022
Epidermolysis bullosa acquisita (EBA) is a rare blistering skin disease induced by autoantibodies directed against type VII collagen. The transfer of antibodies against murine type VII collagen into mice mimics the effector phase of EBA and results in a ...
Bieber, Katja, Ehlers-Jeske, Elvira, Gruner, Caroline, Karsten, Christian Marcel, Kähler, Katja Hendrika, Kenno, Samyr, Kleingarn, Marie, Köhl, Jörg, Ludwig, Ralf J., Sadik, Christian David, Schanzenbacher, Jovan, Schmidt, Enno, Seiler, Daniel Leonard   +12 more
core   +1 more source

The ‘C3aR antagonist’ SB290157 is a partial C5aR2 agonist [PDF]

, 2020
ABSTRACT Innate immune complement activation generates the C3 and C5 protein cleavage products C3a and C5a, defined classically as anaphylatoxins. C3a activates C3a receptors (C3aR), while C5a activates two receptors (C5aR1 and C5aR2) to exert their immunomodulatory activities.
Xaria X. Li, Vinod Kumar, John D. Lee, Trent M. Woodruff   +3 more
openaire   +1 more source