The insider's perspective: The intracellular complosome and immune cell dynamics in cancer [PDF]
Clinical and Translational MedicineComplement is increasingly recognised as a driver and modulator of antitumour immunity, with context‐dependent effects across T cells, myeloid subsets, stromal elements and tumour cells.
Alexandra Bennion +2 more
doaj +3 more sources
The Controversial C5a Receptor C5aR2: Its Role in Health and Disease [PDF]
Journal of Immunology Research, 2017 After the discovery of the C5a receptor C5aR1, C5aR2 is the second receptor found to bind C5a and its des-arginine form. As a heptahelical G protein-coupled receptor but devoid of the intracellular Gα signal, C5aR2 is special and confusing. Ramifications
Ting Zhang +2 more
exaly +5 more sources
Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections [PDF]
Virulence, 2019 The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Andreas Klos +2 more
exaly +7 more sources
Tissue Destruction in Bullous Pemphigoid Can Be Complement Independent and May Be Mitigated by C5aR2 [PDF]
Frontiers in Immunology, 2018 Bullous pemphigoid (BP), the most frequent autoimmune bullous disorder, is a paradigmatic autoantibody-mediated disease associated with autoantibodies against BP180 (type XVII collagen, Col17).
Ralf J Ludwig +2 more
exaly +5 more sources
The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury [PDF]
Journal of Neurotrauma, 2017 This study investigated the role of the alternative receptor for complement activation fragment C5a, C5aR2, in secondary inflammatory pathology after contusive spinal cord injury (SCI) in mice.
Faith H Brennan +2 more
exaly +7 more sources
Corrigendum to “The Controversial C5a Receptor C5aR2: Its Role in Health and Disease” [PDF]
Journal of Immunology Research, 2017 [This corrects the article DOI: 10.1155/2017/8193932.].
Ting Zhang, Malgorzata A. Garstka, Ke Li
doaj +4 more sources
The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist [PDF]
Frontiers in Pharmacology, 2021 Innate immune complement activation generates the C3 and C5 protein cleavage products C3a and C5a, defined classically as anaphylatoxins. C3a activates C3aR, while C5a activates two receptors (C5aR1 and C5aR2) to exert their immunomodulatory activities ...
Xaria X. Li +4 more
doaj +4 more sources
A CD4<sup>+</sup> T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction. [PDF]
ImmunityTimely contraction of successful Th1 responses, characterized by downregulation of IFNg production and co-expression of the anti-inflammatory cytokine IL-10, is essential for limiting Th1-driven tissue pathologies and preventing autoimmune disease.
Rahman J +20 more
europepmc +3 more sources
Pathogens, 2015 The complement anaphylatoxin C5a contributes to host defense against Staphylococcus aureus. In this study, we investigated the functional role of the two known C5a receptors, C5aR1 and C5aR2, in the host response to S. aureus. We found that C5aR1−/− mice
Andreas Klos +2 more
exaly +3 more sources
Selective Complement Inhibition in Anti-p200 Pemphigoid: Immune Infiltrate Profiles and Therapeutic Implications Compared to Bullous Pemphigoid [PDF]
BiomoleculesAnti-p200 pemphigoid is an autoimmune blistering disease (AIBD) caused by autoantibodies against laminin β4 and/or γ1, and clinically resembles bullous pemphigoid (BP) as well as the inflammatory variant of epidermolysis bullosa acquisita (EBA).
Shirin Emtenani +5 more
doaj +2 more sources