Results 11 to 20 of about 1,082 (137)

The Controversial C5a Receptor C5aR2: Its Role in Health and Disease [PDF]

Journal of Immunology Research, 2017
After the discovery of the C5a receptor C5aR1, C5aR2 is the second receptor found to bind C5a and its des-arginine form. As a heptahelical G protein-coupled receptor but devoid of the intracellular Gα signal, C5aR2 is special and confusing. Ramifications
Ting Zhang, Ke Li, Malgorzata A Garstka
exaly   +5 more sources

Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections [PDF]

Virulence, 2019
The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Andreas Klos, Kay O Johswich, Jörg Köhl   +2 more
exaly   +8 more sources

Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy [PDF]

Frontiers in Immunology
Pregnancy is a fascinating immunological phenomenon because it allows allogeneic fetal and placental tissues to survive inside the mother. As a component of innate immunity with high inflammatory potential, the complement system must be tightly regulated
Fenna Froehlich, Konstanze Landerholm, Johanna Neeb, Ann-Kathrin Meß, Daniel Leonard Seiler, Tamara Tilburgs, Tamara Tilburgs, Christian Marcel Karsten   +7 more
doaj   +4 more sources

The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist [PDF]

Frontiers in Pharmacology, 2021
Innate immune complement activation generates the C3 and C5 protein cleavage products C3a and C5a, defined classically as anaphylatoxins. C3a activates C3aR, while C5a activates two receptors (C5aR1 and C5aR2) to exert their immunomodulatory activities ...
Xaria X. Li, Vinod Kumar, Richard J. Clark, John D. Lee, Trent M. Woodruff   +4 more
doaj   +5 more sources

An Integrated Analysis of C5AR2 Related to Malignant Properties and Immune Infiltration of Breast Cancer [PDF]

Frontiers in Oncology, 2021
BackgroundC5AR2 (GPR77, C5L2) is the second receptor for C5a that is a potent protein generated by complement activation. C5AR2 can mediate its own signaling events and exert significant immunomodulatory effects through those events. However, research of
Yumeng Zhu, Xiaochao Wang, Yanqing Xu, Lu Chen, Peipei Ding, Jianfeng Chen, Jianfeng Chen, Weiguo Hu, Weiguo Hu   +8 more
doaj   +3 more sources

Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection

Pathogens, 2015
The complement anaphylatoxin C5a contributes to host defense against Staphylococcus aureus. In this study, we investigated the functional role of the two known C5a receptors, C5aR1 and C5aR2, in the host response to S. aureus. We found that C5aR1−/− mice
Andreas Klos, Andreas Beineke, Eva Medina   +2 more
exaly   +3 more sources

Tissue Destruction in Bullous Pemphigoid Can Be Complement Independent and May Be Mitigated by C5aR2 [PDF]

Frontiers in Immunology, 2018
Bullous pemphigoid (BP), the most frequent autoimmune bullous disorder, is a paradigmatic autoantibody-mediated disease associated with autoantibodies against BP180 (type XVII collagen, Col17).
Christian M. Karsten, Tina Beckmann, Maike M. Holtsche, Jenny Tillmann, Sabrina Tofern, Franziska S. Schulze, Eva Nina Heppe, Ralf J. Ludwig, Detlef Zillikens, Inke R. König, Jörg Köhl, Jörg Köhl, Enno Schmidt, Enno Schmidt   +13 more
doaj   +3 more sources

The complement system in human pregnancy and preeclampsia [PDF]

Frontiers in Immunology
Human pregnancy is a complex condition that poses significant challenges for women due to the necessity of a uterus for key processes such as fertilization, embryo implantation, fetal development, and childbirth.
Vijay Kumar, John H. Stewart
doaj   +2 more sources

Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis [PDF]

Critical Care Explorations
IMPORTANCE:. The alternative complement pathway is a key component of host defense against bacteremia and other infections. However, dysregulated activation can contribute to excessive inflammation and worse clinical outcomes during bacteremia and ...
Kyle Inman, MD, Jonathan Chernus, PhD, Myoungkeun Lee, MS, Jonathan K. Alder, PhD, Faraaz Ali Shah, MD, Florian B. Mayr, MD, Timothy Dempsey, MD, S. Mehdi Nouraie, MD, PhD, Charles Dela Cruz, MD, PhD, Viviana P. Ferreira, DVM, PhD, Hrishikesh S. Kulkarni, MD, Nuala J. Meyer, MD, Patrick J. Strollo, MD, Eleanor Feingold, PhD, William Bain, MD   +14 more
doaj   +2 more sources

The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
IntroductionThe function of the second receptor for the complement cleavage product C5a, C5aR2, is poorly understood and often neglected in the immunological context.
Daniel L. Seiler, Katja H. Kähler, Marie Kleingarn, Christian D. Sadik, Christian D. Sadik, Katja Bieber, Katja Bieber, Katja Bieber, Jörg Köhl, Jörg Köhl, Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Christian M. Karsten   +13 more
doaj   +1 more source