Future Needs in Mast Cell Biology. [PDF]
, 2019 The pathophysiological roles of mast cells are still not fully understood, over 140 years since their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct "subpopulations" of mast cells based on a relatively small ...
de Paulis, Amato +3 more
core +2 more sources
The relevance of complement in pemphigoid diseases: A critical appraisal [PDF]
, 2022 Pemphigoid diseases are autoimmune chronic inflammatory skin diseases, which are characterized by blistering of the skin and/or mucous membranes, and circulating and tissue-bound autoantibodies.
Baican, Adrian +14 more
core +1 more source
British Journal of Pharmacology, Volume 180, Issue 22, Page 2898-2915, November 2023., 2023 Background and Purpose Activated fibroblasts deposit fibrotic matrix in chronic kidney disease (CKD) and G‐protein coupled receptors (GPCRs) are the most druggable therapeutic targets. Here, we set out to establish a transcriptional profile that identifies activated kidney fibroblasts and the GPCRs that they express.
Harmandeep Kaur +12 more
wiley +1 more source
GALDIERO is CO-FIRST AUTHOR. Phagocytes as Corrupted Policemen in Cancer-Related Inflammation [PDF]
, 2015 Inflammation is a key component of the tumor microenvironment. Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) are prototypic inflammatory cells in cancer-related inflammation.
Bonavita, Eduardo +3 more
core +1 more source
Combining Genome Wide Association Studies and Differential Gene Expression Data Analyses Identifies Candidate Genes Affecting Mastitis Caused by Two Different Pathogens in the Dairy Cow [PDF]
, 2015 Mastitis is a costly disease which hampers the dairy industry. Inflammation of the mammary gland is commonly caused by bacterial infection, mainly Escherichia coli, Streptococcus uberis and Staphylococcus aureus.
Chen, X +4 more
core +3 more sources
Modulation of neutrophil activity by soluble complement cleavage products — an in-depth analysis [PDF]
, 2022 The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Bernhard, Stefan +14 more
core +2 more sources
Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
Journal of Neuroinflammation, 2022 Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of ...
Klebea Carvalho +10 more
doaj +1 more source
An Inflammation-Centric View of Neurological Disease: Beyond the Neuron [PDF]
, 2018 Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair.
Facci, Laura +3 more
core +2 more sources
Complement peptide receptors in GtoPdb v.2021.3 [PDF]
, 2021 Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [107]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
Cianciulli, Antonia +8 more
core +2 more sources
C5a Receptor Deficiency Alters Energy Utilization and Fat Storage [PDF]
, 2013 Objective: To investigate the impact of whole body C5a receptor (C5aR) deficiency on energy metabolism and fat storage. Design: Male wildtype (WT) and C5aR knockout (C5aRKO) mice were fed a low fat (CHOW) or a high fat high sucrose diet-induced obesity ...
Cianflone, Katherine +10 more
core +3 more sources